INT63935

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 52
Total Number 52
Disease Relevance 24.30
Pain Relevance 33.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 10
skin 6
spinal cord 6
DRG 6
cingulate cortex 5
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 229 100.00 Very High Very High Very High
amygdala 184 100.00 Very High Very High Very High
Lasting pain 107 100.00 Very High Very High Very High
narcan 66 100.00 Very High Very High Very High
nMDA receptor 65 100.00 Very High Very High Very High
antagonist 59 100.00 Very High Very High Very High
Glutamate 31 100.00 Very High Very High Very High
Kinase C 18 100.00 Very High Very High Very High
Analgesic 10 100.00 Very High Very High Very High
adenocard 5 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 254 100.00 Very High Very High Very High
Ganglion Cysts 58 99.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

20 99.84 Very High Very High Very High
Apoptosis 44 99.82 Very High Very High Very High
Injury 146 99.76 Very High Very High Very High
Urological Neuroanatomy 20 99.68 Very High Very High Very High
Neuropathic Pain 150 99.58 Very High Very High Very High
Diabetes Mellitus 132 99.52 Very High Very High Very High
Nervous System Injury 177 99.12 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

48 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that this increased expression of ERK is related to the retrieval and subsequent reconsolidation of the original memory for training.
Positive_regulation (increased) of Gene_expression (expression) of ERK
1) Confidence 0.61 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.15 Pain Relevance 0.29
In normal control spinal slices, capsaicin induced a drastic pERK expression in superficial dorsal horn neurons, which was suppressed by morphine (10 microM), the selective mu-opioid receptor agonist DAMGO [[d-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (1 microM)], and the selective CB1 receptor ACEA agonist [arachidonyl-2'-chloroethylamide (5 microM)].
Positive_regulation (induced) of Gene_expression (expression) of pERK in spinal associated with qutenza, agonist, enkephalin, opioid receptor, dorsal horn neuron and morphine
2) Confidence 0.58 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.46 Pain Relevance 2.12
In contrast, ACEA (10 microM) was still very effective in inhibiting capsaicin-induced pERK expression.
Positive_regulation (induced) of Gene_expression (expression) of pERK associated with qutenza
3) Confidence 0.58 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.24 Pain Relevance 1.97
One week after spinal nerve ligation when neuropathic pain is fully developed, capsaicin induced less pERK expression in the injured L(5)-spinal segment.
Positive_regulation (induced) of Gene_expression (expression) of pERK in spinal nerve associated with qutenza, spinal nerve ligature and neuropathic pain
4) Confidence 0.58 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.47 Pain Relevance 2.28
Electrical stimulation of C-fibers (3 mA) induced pERK expression in dorsal horn neurons in a frequency-dependent manner, indicating that the frequency of electrical stimulation is an important factor which activates the intracellular signal pathway in the spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of pERK in spinal cord associated with c fibre, dorsal horn neuron and spinal cord
5) Confidence 0.58 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.73
To demonstrate the underlying mechanism of this frequency-dependent pERK expression, an NMDA receptor antagonist, MK-801, and a voltage sensitive calcium channel antagonist, nifedipine, were administrated intrathecally before the stimulation.
Positive_regulation (dependent) of Gene_expression (expression) of pERK associated with nmda receptor antagonist, antagonist and calcium channel
6) Confidence 0.58 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.73
Electrical stimulation of C-fiber intensity at different frequencies was applied to the sciatic nerve; the stimuli-induced pERK expression and the activity in dorsal horn neurons were studied by immunohistochemistry and extracellular recording, respectively.
Positive_regulation (induced) of Gene_expression (expression) of pERK in sciatic nerve associated with c fibre, sciatic nerve and dorsal horn neuron
7) Confidence 0.58 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.71
Intrathecal injection of U0126 or ERK antisense ODN markedly suppressed the increase of CCI-induced pERK, pCREB and c-Fos expression in the spinal cord.
Positive_regulation (increase) of Gene_expression (expression) of pERK in spinal cord
8) Confidence 0.56 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15960884 Disease Relevance 0 Pain Relevance 0
Intrathecal injection of U0126 or ERK antisense ODN markedly suppressed the increase of CCI-induced pERK, pCREB and c-Fos expression in the spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of pERK in spinal cord
9) Confidence 0.56 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15960884 Disease Relevance 0 Pain Relevance 0
P10 rats do not develop neuropathic pain and do not show any increase in pERK expression in the RVM following SNI
Positive_regulation (increase) of Gene_expression (expression) of pERK associated with nervous system injury, neuropathic pain and rostral ventromedial medulla
10) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.05 Pain Relevance 0.49
When we counted the number of pERK expressing cells within the RVM day 8 post SNI surgery, there was no difference between the 2 sham operated groups and results were pooled together (Fig. 3B; 134 ± 7).There was a significant increase in pERK expression when animals had received saline SNI treatment, both compared to SSP-SAP SNI and sham animals (Fig. 3B; 174 ± 7 vs 127 ± 7, P < 0.001, and 174 ± 7 vs 134 ± 7, P < 0.01, saline SNI vs SSP-SAP SNI and saline SNI vs sham respectively).


Positive_regulation (increase) of Gene_expression (expression) of pERK associated with nervous system injury and rostral ventromedial medulla
11) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.08 Pain Relevance 0.21
At 1 micromol/L, DADLE also increased the expression and phosphorylation of ERK. 4.
Positive_regulation (increased) of Gene_expression (expression) of ERK
12) Confidence 0.52 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18047635 Disease Relevance 0 Pain Relevance 0.38
Carbachol-induced tyrosine-phosphorylated proteins of 44 and 42 kd were determined by Western blot analysis and identified as activated ERK1 and ERK2 using anti-ERK antibody.
Positive_regulation (activated) of Gene_expression (using) of ERK
13) Confidence 0.50 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
The chronic morphine-induced increases in ERK activity and TH expression in the VTA also were blocked by local infusion of NMDA glutamate receptor antagonists, suggesting a role for glutamate in mediating these drug effects.
Positive_regulation (increases) of Gene_expression (expression) of ERK associated with ventral tegmentum, glutamate, antagonist, glutamate receptor and morphine
14) Confidence 0.49 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.09 Pain Relevance 1.24
Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain

The extracellular signal-regulated kinase (Erk) activity contributes to synaptic plasticity, a key mechanism for learning, memory and chronic pain.

Positive_regulation (induction) of Gene_expression (expression) of Erk in cingulate cortex associated with lasting pain and anterior cingulate cortex
15) Confidence 0.49 Published 2008 Journal Mol Pain Section Title Doc Link PMC2503974 Disease Relevance 0.90 Pain Relevance 0.86
Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain

The extracellular signal-regulated kinase (Erk) activity contributes to synaptic plasticity, a key mechanism for learning, memory and chronic pain.

Positive_regulation (Activation) of in anterior Gene_expression (expression) of Erk in cingulate cortex associated with lasting pain and anterior cingulate cortex
16) Confidence 0.49 Published 2008 Journal Mol Pain Section Title Doc Link PMC2503974 Disease Relevance 0.90 Pain Relevance 0.86
Fig. 2 is a proposed synaptic model showing different subcellular location of P-Erk during two different phases of chronic pain: induction and expression of mechanical allodynia.
Positive_regulation (induction) of Gene_expression (expression) of Erk associated with allodynia and lasting pain
17) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.33 Pain Relevance 1.16
Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury.
Positive_regulation (activation) of Gene_expression (modulation) of ERK associated with injury and apoptosis
18) Confidence 0.49 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.65 Pain Relevance 0.04
Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury.
Positive_regulation (enhancing) of Gene_expression (modulation) of ERK associated with injury and apoptosis
19) Confidence 0.49 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.66 Pain Relevance 0.04
Interrupted anterograde axonal transport at the crush site resulting in the accumulation of ERK-P in the proximal nerve segment may account for the earlier increase in the expression of ERK-P in this part at post-crush day 1 than in the DRG (7 days).
Positive_regulation (increase) of Gene_expression (expression) of ERK in proximal
20) Confidence 0.47 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.24 Pain Relevance 0.05

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