INT63936

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 3
Speculated 8
Reported most in Abstract
Documents 131
Total Number 139
Disease Relevance 49.38
Pain Relevance 73.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 23
spinal 21
spinal cord 19
dorsal horn 17
DRG 10
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 744 100.00 Very High Very High Very High
Spinal cord 677 100.00 Very High Very High Very High
Pain 436 100.00 Very High Very High Very High
Sciatic nerve 362 100.00 Very High Very High Very High
amygdala 347 100.00 Very High Very High Very High
dorsal root ganglion 300 100.00 Very High Very High Very High
Dorsal horn neuron 255 100.00 Very High Very High Very High
Dorsal horn 232 100.00 Very High Very High Very High
Kinase C 162 100.00 Very High Very High Very High
Central nervous system 114 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 423 100.00 Very High Very High Very High
Pain 416 100.00 Very High Very High Very High
Ganglion Cysts 332 100.00 Very High Very High Very High
Injury 234 99.98 Very High Very High Very High
Sciatic Neuropathy 32 99.98 Very High Very High Very High
Arthritis 89 99.96 Very High Very High Very High
Brain Injury 8 99.92 Very High Very High Very High
Diabetes Mellitus 168 99.84 Very High Very High Very High
Nervous System Injury 242 99.80 Very High Very High Very High
Contusions 29 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in spinal ERK phosphorylation was specifically restricted to L6 spinal segment.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK in spinal
1) Confidence 0.70 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.93 Pain Relevance 0.49
During attempts to examine the phosphorylation status of extracellular signal-regulated kinase (ERK) in cerebral cortex immunohistochemically, we determined whether deep anesthesia for euthanasia disturbs the phosphorylation status of ERK, because the anesthesia might influence activity-dependent phosphorylation of ERK.
Spec (might) Positive_regulation (dependent) of Phosphorylation (phosphorylation) of ERK in cerebral cortex associated with anesthesia and cerebral cortex
2) Confidence 0.69 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 18294698 Disease Relevance 0 Pain Relevance 0.75
Movement of the inflamed joint increased ERK phosphorylation in neurones of the superficial and deep ipislateral dorsal horn laminae of L3-L5 spinal cord segments.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK in dorsal horn associated with dorsal horn and spinal cord
3) Confidence 0.68 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.49 Pain Relevance 0.25
Interestingly, in cases of chronic spinal cord transection at high thoracic segments, ERK phosphorylation was upregulated in L6 segment, that is, in a distal segment to the injury site.
Positive_regulation (upregulated) of in spinal cord Phosphorylation (phosphorylation) of ERK in distal segment associated with injury and spinal cord
4) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 1.18 Pain Relevance 0.44
The reasons why ERK phosphorylation is upregulated by acute and chronic noxious conditions are various but a common denominator can be found.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of ERK
5) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.46 Pain Relevance 0.44
These results suggest that chronic BDNF elicits a compensatory increase in the phosphorylation of the remaining ERK molecules and thereby prevents any additional increase in response to drug exposure.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK
6) Confidence 0.68 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.07 Pain Relevance 1.09
The result of Western blotting showed that the phosphorylation level of ERK 1/2 in the spinal cord was increased at one hour; then 12 and 24 h after LPS injection the level decreased, while the total ERK 1/2 level seemed unchanged.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK in spinal cord associated with spinal cord
7) Confidence 0.67 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18311521 Disease Relevance 0.15 Pain Relevance 0.45
The increase of phosphorylation of ERK 1/2 in microglia of spinal cord after LPS injection implicates that ERK signaling pathway involves intracellular activity of microglia responding to the inflammation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK in microglia associated with inflammation and spinal cord
8) Confidence 0.67 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18311521 Disease Relevance 0.26 Pain Relevance 0.49
Although stimulation in any frequency can induce the phosphorylation of ERK, only high frequency electrical stimulation (0.5 Hz and 10 Hz) activates NMDA receptors that seem capable of promoting VSCCs activation in inducing the pERK stain.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK associated with nmda receptor
9) Confidence 0.67 Published 2007 Journal Mol Pain Section Body Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.38
Two minutes after running on the treadmill apparatus, phosphorylation of ERK was induced in neurons in the superficial laminae in the LCS group but not in the sham group, whereas there was no change in the deeper laminae.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of ERK in neurons associated with pathologic constriction
10) Confidence 0.66 Published 2004 Journal Pain Section Abstract Doc Link 15082127 Disease Relevance 1.01 Pain Relevance 0.56
Finally, stimulation of central amygdala ERK and CREB phosphorylation by NMDA enhanced drug CPP after 1 d of withdrawal from morphine, an effect reversed by U0126.
Positive_regulation (stimulation) of Phosphorylation (phosphorylation) of ERK in amygdala associated with withdrawal, amygdala and morphine
11) Confidence 0.66 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19052216 Disease Relevance 0 Pain Relevance 1.29
Phosphorylated (phospho-) ERK-IR was also activated in response to ACI.
Positive_regulation (activated) of Phosphorylation (Phosphorylated) of ERK-IR associated with injury
12) Confidence 0.66 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15265585 Disease Relevance 0.82 Pain Relevance 0.21
Obata and colleagues have administered NGF either intrathecally or intraneurally and found an increase in the ERK phosphorylation in L4/5 DRG [13,18].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK associated with nerve growth factor
13) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.33 Pain Relevance 0.14
At later time points, 1, 2 and 4 weeks post-lesion, elevated ERK-P in the proximal stump may be due to the upregulated ERK phosphorylation in the cell bodies.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of ERK in proximal
14) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.23 Pain Relevance 0.04
Conversely, imipramine did not reduce the hippocampal phosphorylation of both ERK subtypes whereas it selectively increased ERK 1 phosphorylation in the cytosolic compartment of frontal cortex suggesting a drug-specific effect on this intracellular target.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK in frontal cortex associated with urological neuroanatomy
15) Confidence 0.64 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935071 Disease Relevance 0.28 Pain Relevance 0.61
Furthermore, l-THP inhibited the increased phosphorylation of ERK and CREB in nucleus accumbens and hippocampus of rats.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK in nucleus accumbens associated with nucleus accumbens and hippocampus
16) Confidence 0.62 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19071107 Disease Relevance 0.16 Pain Relevance 1.12
Phosphorylation of ERK significantly increased but there were no significant effects on cortical expression of ERK, Jun and p-38.
Positive_regulation (increased) of Phosphorylation (Phosphorylation) of ERK
17) Confidence 0.61 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.70 Pain Relevance 0.12
We also observed an increase in ERK phosphorylation in rats simply exposed to the extinction context, which might be related to generalized fear to the chamber.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ERK associated with anxiety disorder
18) Confidence 0.61 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.17 Pain Relevance 0.27
We observed that exposure to four extinction trials significantly increased ERK phosphorylation, even though this manipulation did not result in any extinction.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of ERK
19) Confidence 0.61 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.15 Pain Relevance 0.30
The phosphorylation level of ERK(1)/ERK(2) were elevated in both P and S groups, but the level of phosphorlation ERK(1)/ERK(2) were lower in S group than that in P group.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of ERK
20) Confidence 0.60 Published 2010 Journal Cardiovasc Ther Section Abstract Doc Link 20074256 Disease Relevance 0.26 Pain Relevance 0.08

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