INT63957

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 18.56
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Tnnt2) cytoplasm (Tnnt2)
Anatomy Link Frequency
coronary artery 1
myocardial cell 1
platelet 1
Tnnt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 83 99.98 Very High Very High Very High
antagonist 11 98.78 Very High Very High Very High
Pain 5 97.72 Very High Very High Very High
imagery 99 94.48 High High
Inflammatory marker 4 94.00 High High
anesthesia 3 72.80 Quite High
Inflammation 21 72.60 Quite High
fibrosis 10 68.44 Quite High
Calcium channel 6 5.00 Very Low Very Low Very Low
chest pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 69 99.98 Very High Very High Very High
Myocardial Infarction 112 99.96 Very High Very High Very High
Infarction 14 99.92 Very High Very High Very High
Acute Myocarditis 116 99.72 Very High Very High Very High
Death 12 98.84 Very High Very High Very High
Renal Disease 37 98.72 Very High Very High Very High
Chronic Renal Failure 88 98.36 Very High Very High Very High
Injury 18 98.10 Very High Very High Very High
Pain 5 97.72 Very High Very High Very High
Necrosis 11 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nineteen patients with elevated TnT had a greater QTd compared to patients with normal TnT (74 +/- 29 vs. 56 +/- 20 ms; p = 0.008).
Positive_regulation (elevated) of TnT
1) Confidence 0.69 Published 2004 Journal Acta Cardiol Section Body Doc Link 15255460 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: We conclude that elevated TnT levels in the postoperative period confer a 15-fold increase in mortality during the first year after surgery.
Positive_regulation (elevated) of TnT
2) Confidence 0.69 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15352951 Disease Relevance 0 Pain Relevance 0
RESULTS: Perfusion defect was detected in 42 patients and elevated TnT was observed in 23 patients.
Positive_regulation (elevated) of TnT
3) Confidence 0.68 Published 2003 Journal Int J Cardiovasc Imaging Section Body Doc Link 14690190 Disease Relevance 0.08 Pain Relevance 0
The patients with elevated TnT levels had more perfusion defect numbers than those with normal TnT levels (8.2 +/- 2.9 vs. 5.3 +/- 2.2; p = 0.0007).
Positive_regulation (elevated) of TnT
4) Confidence 0.68 Published 2003 Journal Int J Cardiovasc Imaging Section Body Doc Link 14690190 Disease Relevance 0.08 Pain Relevance 0
All of the patients with an elevated TnT have also perfusion defect in RPI.
Positive_regulation (elevated) of TnT
5) Confidence 0.68 Published 2003 Journal Int J Cardiovasc Imaging Section Body Doc Link 14690190 Disease Relevance 0.08 Pain Relevance 0
Of the 100 patients (57 men, 43 women), TnT was increased in 21 of 21 with acute MI and 15 of 41 with unstable angina.
Positive_regulation (increased) of TnT associated with angina
6) Confidence 0.65 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9489973 Disease Relevance 0.84 Pain Relevance 0.36
Unlike creatine kinase-MB isoenzymes, TnT is increased in a subset of patients with unstable angina, and these may be at higher risk for subsequent cardiac events.
Positive_regulation (increased) of TnT associated with angina
7) Confidence 0.65 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9489973 Disease Relevance 0.51 Pain Relevance 0.14
An increase in the rate of cardiac death or myocardial infarction was seen during follow-up, with increasing levels of TnT.
Positive_regulation (increasing) of TnT associated with myocardial infarction and death
8) Confidence 0.62 Published 1998 Journal Eur. Heart J. Section Abstract Doc Link 9857941 Disease Relevance 0.57 Pain Relevance 0.09
BACKGROUND: The aim of this study was to evaluate the significance of elevated postoperative Troponin T (TnT) levels in an elderly population undergoing non-cardiac surgery.
Positive_regulation (elevated) of TnT
9) Confidence 0.50 Published 2004 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 15352951 Disease Relevance 0 Pain Relevance 0
Median, 5th and 95th percentiles of maximum TnT values within the diagnostic subgroups showed that serum TnT was increased five-fold more than CK MBmass.
Positive_regulation (increased) of TnT
10) Confidence 0.49 Published 1997 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 9211015 Disease Relevance 1.05 Pain Relevance 0.29
BACKGROUND: The CAPTURE (C7E3 fab AntiPlatelet Therapy in Unstable REfactory angina) trial enrolled patients with refractory unstable angina and documented a therapeutic benefit for abciximab, a platelet glycoprotein IIb/IIIa receptor antagonist, that was particularly evident in patients with elevated troponin T (TnT) levels.
Positive_regulation (elevated) of TnT in platelet associated with angina and antagonist
11) Confidence 0.48 Published 1999 Journal Circulation Section Abstract Doc Link 10510053 Disease Relevance 0.27 Pain Relevance 0.32
Ninety percent of patients who sustained acute MI had a TnT increase detected within 4 hours of presentation.
Positive_regulation (increase) of TnT
12) Confidence 0.44 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9489973 Disease Relevance 0.82 Pain Relevance 0.36
One of the 38 patients with stable angina had an increased TnT value and died 5 months later of a noncardiac cause.
Positive_regulation (increased) of TnT associated with angina
13) Confidence 0.44 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9489973 Disease Relevance 0.83 Pain Relevance 0.37
One of these substantial reasons for these minor myocardial cell necrosis is beside the endothelial injury the activation of the platelets and the coagulation system. - During the therapy with hirudin increases of TnT and TnI was not observed.
Positive_regulation (increases) of TnT in myocardial cell associated with necrosis and injury
14) Confidence 0.34 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 0.82 Pain Relevance 0.23
After coronary angioplasty and heparin treatment all patients had once more an elevation of TnT and TnI 8 and 27 hours after the invasive therapy.
Positive_regulation (elevation) of TnT
15) Confidence 0.34 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 0.93 Pain Relevance 0.36
CONCLUSIONS: Complex lesion characteristics and visible thrombus formation at baseline were significantly linked to TnT elevation.
Positive_regulation (elevation) of TnT
16) Confidence 0.32 Published 1999 Journal Circulation Section Body Doc Link 10510053 Disease Relevance 0 Pain Relevance 0
Increased TnT detects minor myocardial damage (MMD) in over 30% of patients with UAP, although CK MBmass remains below its discriminator.
Positive_regulation (Increased) of TnT associated with angina
17) Confidence 0.29 Published 1997 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 9211015 Disease Relevance 1.09 Pain Relevance 0.38
The sensitivity, specificity, positive predictive accuracy (PPA) and negative predictive accuracy (NPA) were all calculated for BNP, TnT and for the composite of BNP and TnT.
Positive_regulation (calculated) of TnT
18) Confidence 0.27 Published 2007 Journal QJM Section Body Doc Link 18089541 Disease Relevance 0.14 Pain Relevance 0
The sensitivity, specificity, positive predictive accuracy (PPA) and negative predictive accuracy (NPA) were all calculated for BNP, TnT and for the composite of BNP and TnT.
Positive_regulation (calculated) of TnT
19) Confidence 0.27 Published 2007 Journal QJM Section Body Doc Link 18089541 Disease Relevance 0.14 Pain Relevance 0
Elevated TnT or TnI concentrations predicted a significantly increased mortality.
Positive_regulation (Elevated) of TnT
20) Confidence 0.20 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 1.06 Pain Relevance 0.40

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