INT63975

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2011
Negated 8
Speculated 1
Reported most in Body
Documents 175
Total Number 181
Disease Relevance 134.13
Pain Relevance 54.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
T cells 11
macrophages 6
skin 4
eye 3
Plasma 3
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3525 100.00 Very High Very High Very High
cytokine 3164 100.00 Very High Very High Very High
chemokine 271 100.00 Very High Very High Very High
methotrexate 373 99.98 Very High Very High Very High
Paracetamol 67 99.84 Very High Very High Very High
Inflammatory response 238 99.78 Very High Very High Very High
Central nervous system 539 99.68 Very High Very High Very High
Sciatic nerve 394 99.68 Very High Very High Very High
psoriasis 34 99.48 Very High Very High Very High
cocaine 61 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3839 100.00 Very High Very High Very High
Cancer 1341 100.00 Very High Very High Very High
Necrosis 515 100.00 Very High Very High Very High
Obesity 177 100.00 Very High Very High Very High
Infection 1568 99.96 Very High Very High Very High
Graft Vs Host Disease 60 99.90 Very High Very High Very High
Targeted Disruption 1137 99.84 Very High Very High Very High
Injury 585 99.82 Very High Very High Very High
Lymphoproliferative Disease 16 99.78 Very High Very High Very High
Creutzfeldt Jakob Disease 2 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytokine arrays performed in duplicate time-course experiments revealed substantial increases in IL-10, IL-2, IL-6, and MIP-1?
Positive_regulation (increases) of IL-10 associated with cytokine
1) Confidence 0.68 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.18
Notably, we observed a 20-fold increase in IL-10 levels in the B cell cultures transduced with M2 with 17.5 ng/mL of IL-10 in the M2-transduced cultures as compared to 0.9 ng/mL in the control retroviral supernatants at day 6 post-transduction (Figure 4E).
Positive_regulation (increase) of IL-10 in B cell
2) Confidence 0.68 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.13
In this case, the bacterial regrowth is usually accompanied by concomitant increase in the tissue levels of IL-10 and transforming growth factor-beta (TGF-beta), well known immunosuppressive cytokines.
Positive_regulation (increase) of IL-10 associated with cytokine
3) Confidence 0.67 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.54 Pain Relevance 0.47
The central nervous system, including the brain (data not shown) and the spinal cord itself, seemed resistant to the effects of increased IL-10, as H&E staining of the spinal cord tissue revealed no evidence of cell infiltrate in Tg?
Positive_regulation (increased) of IL-10 in brain associated with central nervous system and spinal cord
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.28 Pain Relevance 0.40
IL-10 was changed inversely to TNF-alpha levels only in the desipramine-treated animals.
Positive_regulation (changed) of IL-10 associated with desipramine
5) Confidence 0.63 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17584982 Disease Relevance 0.77 Pain Relevance 0.98
We speculate that the increased level of IL-10 in this group could be a counterbalance, modulating the robust response of TNF-?.
Positive_regulation (increased) of IL-10
6) Confidence 0.59 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.72 Pain Relevance 0.08
Moreover, IL-10/4/6-/- mice were also resistant to the enhanced susceptibility to AILD and expressed relatively low levels of most proinflammatory factor genes that were elevated in the IL-10/4-/- mice.
Positive_regulation (elevated) of IL-10 associated with liver disease
7) Confidence 0.58 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17305405 Disease Relevance 0.91 Pain Relevance 0.57
In contrast, increases in IL-10 were more rapid and more pronounced.
Positive_regulation (increases) of IL-10
8) Confidence 0.58 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.84 Pain Relevance 0.81
No significant change in lung IL-10 content was noted in the saline, NI (poorly soluble particles of low toxicity, WC) or RA (inflammatory but not fibrogenic particles) groups, indicating that IL-10 induction in mice seems specific to the fibrotic process.
Positive_regulation (induction) of IL-10 in lung associated with fibrosis, toxicity, inflammation and rheumatoid arthritis
9) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.65 Pain Relevance 0.41
No similar IL-10 induction was noted in treated rats (Figure 4 B).
Neg (No) Positive_regulation (induction) of IL-10
10) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.32 Pain Relevance 0.20
Interestingly, pretreatment with L-NAME, a non-selective NOS inhibitor, augmented the increase of IL-10 in CFA mice.
Positive_regulation (increase) of IL-10
11) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.52 Pain Relevance 0.70
gene expression and has a differential effect on the increase of IL-10 in plantar skin after CFA
Positive_regulation (increase) of IL-10 in skin
12) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.23 Pain Relevance 0.28
The increase of IL-10 was augmented in mice pretreated with 7-NINA or L-NAME, but reduced in mice receiving AG or L-NIO, at 6 and 16 h after CFA (Fig. 4C, P < 0.05 and P < 0.001).


Positive_regulation (increase) of IL-10
13) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.27 Pain Relevance 0.12
In addition, we detected for the first time that CFA also induced an upregulation of IL-10.
Positive_regulation (upregulation) of IL-10
14) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.63 Pain Relevance 0.73
However, in one study the TZDs increased IL4 and IL10, and stimulated GATA3 expression (a transcription factor which shifts cells towards Th2 phenotype) [50]; although in other studies PPAR?
Positive_regulation (increased) of IL10
15) Confidence 0.55 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.44 Pain Relevance 0.36
Further, when splenoctyes from healthy mice treated with DHT in vivo were stimulated with anti-CD3 antibody, increased levels of IL-10 and decreased levels IL-12 were observed [78].
Positive_regulation (increased) of IL-10
16) Confidence 0.50 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.79 Pain Relevance 0.36
T cell lines from PLP 139-151 immunized mice stimulated with PLP 139-151 in the presence of DHT also resulted in increased IL-10 and decreased IFN-?
Positive_regulation (increased) of IL-10 in T cell
17) Confidence 0.50 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.62 Pain Relevance 0.32
Cytokine gene knockout mice were then used to show that DHT directly increased IL-10 from CD4+ T lymphoctyes with a subsequent indirect decrease in IL-12 [78].
Positive_regulation (increased) of IL-10 associated with targeted disruption and cytokine
18) Confidence 0.50 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.91 Pain Relevance 0.38
When splenocytes from mice with EAE treated in vivo with DHT or placebo were stimulated with MBP, those from DHT treated had increased IL-10 and decreased IFN-?
Positive_regulation (increased) of IL-10 associated with multiple sclerosis
19) Confidence 0.50 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.76 Pain Relevance 0.36
Notably, transfer of culture supernatants from M2 expressing C57Bl/6 B cells, or addition of recombinant murine IL-10, did not result in dominance of the M2.Stop retrovirus transduced (i.e., Thy1.1+) population in the absence of M2 protein expression, leading us to hypothesize that some other function(s) of the M2 protein augments IL-10 signaling.
Positive_regulation (augments) of IL-10 in B cells
20) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.05 Pain Relevance 0

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