INT63977

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 18.49
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele)
cellular_component (Sele)
Anatomy Link Frequency
plasma 5
joint 2
stroma 1
white blood cell 1
platelet 1
Sele (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 14 99.92 Very High Very High Very High
depression 9 99.92 Very High Very High Very High
Angina 45 99.72 Very High Very High Very High
ischemia 7 99.56 Very High Very High Very High
Inflammation 69 98.12 Very High Very High Very High
Pain 8 95.64 Very High Very High Very High
withdrawal 4 90.28 High High
Inflammatory marker 8 85.40 High High
cva 4 81.04 Quite High
cINOD 6 80.24 Quite High
Disease Link Frequency Relevance Heat
Adhesions 73 100.00 Very High Very High Very High
Rheumatoid Arthritis 18 99.92 Very High Very High Very High
Depression 9 99.92 Very High Very High Very High
Syndrome 22 99.86 Very High Very High Very High
Cancer 5 99.80 Very High Very High Very High
Angina 18 99.72 Very High Very High Very High
Myocardial Infarction 34 99.68 Very High Very High Very High
Necrosis 2 99.56 Very High Very High Very High
Coronary Artery Disease 30 99.36 Very High Very High Very High
Cv General 3 Under Development 29 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, immune complexes fixing C1q bind to endothelial receptors, thus triggering an upregulation of adhesion molecules, such as E-selectin and intercellular and vascular cell adhesion molecules 1, on the endothelium surface.
Positive_regulation (upregulation) of E-selectin in endothelium associated with adhesions
1) Confidence 0.68 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114307 Disease Relevance 1.46 Pain Relevance 0.41
CONCLUSIONS: We have shown an increased level of shed E-selectin in patients destined for restenosis and suggest that this work further supports a role for white blood cell/endothelial interaction in restenosis after angioplasty.


Positive_regulation (increased) of E-selectin in white blood cell
2) Confidence 0.65 Published 1997 Journal Circulation Section Body Doc Link 9133511 Disease Relevance 0 Pain Relevance 0
Mean E-selectin concentration was elevated among cases (P=.0009) compared to controls.
Positive_regulation (elevated) of E-selectin
3) Confidence 0.40 Published 2005 Journal J. Diabetes Complicat. Section Abstract Doc Link 15993351 Disease Relevance 1.74 Pain Relevance 0.17
Increased levels of soluble adhesion molecules E-selectin and P-selectin in patients with cardiac syndrome X.
Positive_regulation (Increased) of E-selectin associated with syndrome and adhesions
4) Confidence 0.29 Published 2005 Journal Angiology Section Title Doc Link 15889194 Disease Relevance 1.08 Pain Relevance 0.25
To characterize the role of circulating intercellular adhesion molecules (ICAM-1) and E-selectin in patients with acute coronary syndrome, serum levels of ICAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay (ELISA).
Positive_regulation (circulating) of E-selectin associated with acute coronary syndrome and adhesions
5) Confidence 0.27 Published 1996 Journal Chest Section Abstract Doc Link 8769521 Disease Relevance 0.71 Pain Relevance 0.15
RESULTS: There was a significant increase in E-selectin (p < 0.05) in patients with unstable angina at admission and ten days later.
Positive_regulation (increase) of E-selectin
6) Confidence 0.22 Published 2003 Journal Rev Esp Cardiol Section Body Doc Link 12605758 Disease Relevance 0.16 Pain Relevance 0
Significant increase of E-selectin concentration as induced by ST may reflect endothelial response to exercise.
Positive_regulation (increase) of E-selectin
7) Confidence 0.21 Published 2001 Journal Pol. Arch. Med. Wewn. Section Body Doc Link 12026533 Disease Relevance 0 Pain Relevance 0
In conclusion, patients with syndrome X had increased plasma concentrations of soluble adhesion molecules, E-selectin and P-selectin, reflecting an ongoing chronic inflammation involved with endothelial dysfunction and enhanced platelet activation/damage in this setting.
Positive_regulation (increased) of E-selectin in platelet associated with inflammation, syndrome and adhesions
8) Confidence 0.19 Published 2005 Journal Angiology Section Abstract Doc Link 15889194 Disease Relevance 1.38 Pain Relevance 0.29
HYPOTHESIS: The purpose of this study was to determine whether soluble E-selectin, P-selectin and L-selectin levels are increased in patients with unstable angina (UA).
Spec (whether) Positive_regulation (increased) of E-selectin
9) Confidence 0.16 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259814 Disease Relevance 0.10 Pain Relevance 0
CONCLUSIONS: The serum E-selectin concentration is markedly elevated in severe AP and is less in mild AP but not in NPAAP.
Positive_regulation (elevated) of E-selectin
10) Confidence 0.14 Published 2003 Journal Pancreas Section Body Doc Link 12604912 Disease Relevance 0.11 Pain Relevance 0
We have demonstrated increased levels of the circulating soluble adhesion molecules (sCAMs), ICAM-1, VCAM-1, and E-selectin in patients with unstable angina compared with healthy controls.
Positive_regulation (increased) of E-selectin associated with angina and adhesions
11) Confidence 0.12 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9294992 Disease Relevance 0.53 Pain Relevance 0.26
Soluble E-selectin and intercellular adhesion molecule-1 plasma levels increase during acute myocardial infarction.
Positive_regulation (increase) of E-selectin in plasma associated with myocardial infarction and adhesions
12) Confidence 0.09 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 9335404 Disease Relevance 1.00 Pain Relevance 0.18
There was no elevation in the E-selectin concentration in NPAAP patients, and IL-10 levels remained unchanged in mild AP.
Neg (no) Positive_regulation (elevation) of E-selectin
13) Confidence 0.09 Published 2003 Journal Pancreas Section Body Doc Link 12604912 Disease Relevance 0.13 Pain Relevance 0
However, E-selectin plasma levels remained unchanged in response to myocardial ischemia.
Neg (unchanged) Positive_regulation (unchanged) of E-selectin in plasma associated with coronary artery disease and ischemia
14) Confidence 0.08 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10442400 Disease Relevance 1.12 Pain Relevance 0.95
Uric acid (UA) is a major antioxidant, but, like most molecules of this category,68 it can also induce opposite effects if concentrations are sufficiently high.69 There are likely to be concentration thresholds delineating positive from negative effects of such substances; acute and even relatively high UA levels protect against oxidative stress70, but chronically elevated UA levels are linked to MSs, reduced adiponectin and elevated E-selectin, in parallel with positive effects such as reduced nitrotyrosine and increased total antioxidant capacity.71 Thus, high UA levels could be a compensatory mechanism that counteracts the oxidative stress related to metabolic or vascular disturbances.72
Positive_regulation (elevated) of E-selectin associated with stress and syndrome
15) Confidence 0.07 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.57 Pain Relevance 0
E-selectin plasma level was constantly elevated compared with controls but did not differ among the groups dependent on the incidence of depression.
Positive_regulation (elevated) of E-selectin in plasma associated with depression
16) Confidence 0.06 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12960610 Disease Relevance 1.77 Pain Relevance 0.45
OBJECTIVE: The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation.
Spec (whether) Positive_regulation (elevated) of E-selectin in plasma associated with angina and adhesions
17) Confidence 0.06 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9415270 Disease Relevance 0.47 Pain Relevance 0.17
Both normal bladders were negative for ICAM-1 and P-selectin and faintly positive for E-selectin, and one was weakly positive for talin and vinculin; the normal foreskin was negative.
Positive_regulation (positive) of E-selectin in bladders
18) Confidence 0.05 Published 2004 Journal Urology Section Body Doc Link 15072882 Disease Relevance 0.15 Pain Relevance 0
CONCLUSIONS: Interleukin-6 was greater in acute myocardial infarction than in unstable angina; E-selectin was positively associated with a previous myocardial infarction and inversely related to age.
Positive_regulation (related) of E-selectin
19) Confidence 0.04 Published 2005 Journal Coron. Artery Dis. Section Body Doc Link 16205449 Disease Relevance 0 Pain Relevance 0
Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis.
Positive_regulation (Circulating) of E-selectin in joint associated with necrosis, cancer, rheumatoid arthritis and arthropathy
20) Confidence 0.04 Published 2009 Journal Rheumatol. Int. Section Title Doc Link 18726101 Disease Relevance 0.86 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox