INT63978

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Context Info
Confidence 0.18
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.59
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele)
cellular_component (Sele)
Anatomy Link Frequency
plasma 2
coronary sinus 2
lung 2
neutrophil 2
Sele (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 8 100.00 Very High Very High Very High
Inflammation 64 97.72 Very High Very High Very High
Angina 14 96.84 Very High Very High Very High
cytokine 17 83.76 Quite High
chemokine 4 68.04 Quite High
rheumatoid arthritis 3 50.00 Quite Low
Arthritis 1 41.72 Quite Low
Pain 1 10.00 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 100.00 Very High Very High Very High
Acute Coronary Syndrome 7 99.84 Very High Very High Very High
Hypersensitivity 86 99.64 Very High Very High Very High
Lyme Disease 74 99.38 Very High Very High Very High
Adhesions 18 98.34 Very High Very High Very High
Coronary Artery Disease 6 98.00 Very High Very High Very High
Cv General 3 Under Development 13 96.84 Very High Very High Very High
Rheumatoid Arthritis 3 96.36 Very High Very High Very High
Asthma 24 95.68 Very High Very High Very High
Myocardial Infarction 5 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Female sex hormones mediate the allergic lung reaction by regulating the release of inflammatory mediators and the expression of lung E-selectin in rats

Background

Regulation (regulating) of Gene_expression (expression) of E-selectin in lung associated with inflammatory mediators and hypersensitivity
1) Confidence 0.18 Published 2010 Journal Respir Res Section Title Doc Link PMC2936382 Disease Relevance 0.59 Pain Relevance 0.13
To characterize the role of circulating intercellular adhesion molecules (ICAM-1) and E-selectin in patients with acute coronary syndrome, serum levels of ICAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay (ELISA).
Regulation (measured) of Gene_expression (levels) of E-selectin associated with acute coronary syndrome and adhesions
2) Confidence 0.15 Published 1996 Journal Chest Section Abstract Doc Link 8769521 Disease Relevance 0.75 Pain Relevance 0.17
In vitro, a Bb lipoprotein has been shown to upregulate expression of endothelial cell E-selectin, VCAM-1, ICAM-1 and neutrophil migration [19].
Regulation (upregulate) of Gene_expression (expression) of E-selectin in neutrophil associated with lyme disease
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605548 Disease Relevance 1.80 Pain Relevance 0.38
METHODS: Plasma thrombomodulin levels and the values of the plasma adhesion molecules VCAM-1 (vascular cell adhesion molecule 1), E-selectin (CD62E), and ICAM-1 (intercellular adhesion molecule 1, CD 54) were measured by ELISA during a 7-day period of treatment with orally-administered iloprost in 14 patients with active rheumatoid arthritis.
Regulation (measured) of Gene_expression (values) of E-selectin in plasma
4) Confidence 0.02 Published 2006 Journal Rheumatol. Int. Section Body Doc Link 15700117 Disease Relevance 0.19 Pain Relevance 0
In addition, plasma levels of the tissue factor, tissue factor pathway inhibitor, P-selectin, E-selectin and ICAM-1 were measured in the blood withdrawn from the coronary sinus in a subgroup of patients with unstable angina pectoris and stable coronary artery disease in which the difference between concentrations in the coronary sinus and systemic blood was calculated.
Regulation (measured) of Gene_expression (levels) of E-selectin in coronary sinus associated with angina and coronary artery disease
5) Confidence 0.01 Published 2003 Journal Physiol Res Section Abstract Doc Link 14640893 Disease Relevance 1.26 Pain Relevance 0.56

General Comments

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