INT63979

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 10.64
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele)
cellular_component (Sele)
Anatomy Link Frequency
plasma 3
endothelial cell 1
coronary sinus 1
chest 1
polymorphonuclear leukocyte 1
Sele (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 48 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
antagonist 1 99.70 Very High Very High Very High
ischemia 11 99.56 Very High Very High Very High
cytokine 16 97.72 Very High Very High Very High
Inflammation 50 97.40 Very High Very High Very High
Restless leg syndrome 1 59.64 Quite High
spinal inflammation 1 55.16 Quite High
rheumatoid arthritis 4 50.00 Quite Low
abdominal pain 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 43 100.00 Very High Very High Very High
Angina 20 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Acute Coronary Syndrome 13 99.52 Very High Very High Very High
Coronary Artery Disease 21 99.36 Very High Very High Very High
Brain Injury 36 99.04 Very High Very High Very High
Cardiovascular Disease 13 99.04 Very High Very High Very High
Overdose 1 98.78 Very High Very High Very High
INFLAMMATION 54 97.40 Very High Very High Very High
Urticaria 56 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semiquantitative PCR revealed that E-selectin and IL-6 gene expressions were increased in rats following LPS injection, and an overdose of tamoxifen, an estrogen receptor antagonist, reversed the effect of 17beta-estradiol on E-selectin, but not its effect on IL-6.
Regulation (effect) of E-selectin associated with antagonist and overdose
1) Confidence 0.54 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384138 Disease Relevance 0.84 Pain Relevance 0.19
In conclusion, serum levels of ICAM-1 were elevated in patients with acute coronary syndrome within 24 h, while the E-selectin levels did not change significantly.
Neg (not) Regulation (change) of E-selectin associated with acute coronary syndrome
2) Confidence 0.34 Published 1996 Journal Chest Section Abstract Doc Link 8769521 Disease Relevance 0.79 Pain Relevance 0.13
E-Selectin plasma levels are modulated by the E-Selectin Ser128Arg genotype, and predict the risk for restenosis after PTA in patients with PAD.
Regulation (modulated) of E-Selectin in plasma associated with cardiovascular disease and peripheral arterial disease
3) Confidence 0.26 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 14691583 Disease Relevance 0.67 Pain Relevance 0.09
, and IL-6) as well as 3 cellular adhesion molecule (ICAM-1, VCAM, and E-selectin) mRNA levels following PBBI (Fig. 2).
Regulation (molecule) of E-selectin associated with brain injury and adhesions
4) Confidence 0.16 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1933533 Disease Relevance 1.11 Pain Relevance 0.26
To characterize the role of circulating intercellular adhesion molecules (ICAM-1) and E-selectin in patients with acute coronary syndrome, serum levels of ICAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay (ELISA).
Regulation (measured) of E-selectin associated with acute coronary syndrome and adhesions
5) Confidence 0.15 Published 1996 Journal Chest Section Abstract Doc Link 8769521 Disease Relevance 0.75 Pain Relevance 0.17
However, E-selectin plasma levels remained unchanged in response to myocardial ischemia.
Neg (unchanged) Regulation (unchanged) of E-selectin in plasma associated with coronary artery disease and ischemia
6) Confidence 0.08 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10442400 Disease Relevance 1.12 Pain Relevance 0.95
On the contrary, the mean values of soluble E-selectin in the patients with ischemic cardiac pain during chest pain and in the absence of this symptom, as well as those in the patients with noncardiac chest pain during or without symptoms, remained unchanged in comparison with the control group.
Neg (unchanged) Regulation (unchanged) of E-selectin in chest associated with pain and angina
7) Confidence 0.08 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10442400 Disease Relevance 1.44 Pain Relevance 1.23
The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation.
Regulation (role) of E-selectin in endothelial cell associated with inflammation and adhesions
8) Confidence 0.03 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17305540 Disease Relevance 1.00 Pain Relevance 0.14
RESULTS: Serum concentrations of E-selectin, IL-10, and IL-6 and plasma concentrations of polymorphonuclear leukocyte elastase (determined on days 1-3, 5, and 10 after admission) were the highest in severe AP during the first 3 days and then declined.
Regulation (concentrations) of E-selectin in polymorphonuclear leukocyte
9) Confidence 0.02 Published 2003 Journal Pancreas Section Body Doc Link 12604912 Disease Relevance 0.16 Pain Relevance 0
In addition, plasma levels of the tissue factor, tissue factor pathway inhibitor, P-selectin, E-selectin and ICAM-1 were measured in the blood withdrawn from the coronary sinus in a subgroup of patients with unstable angina pectoris and stable coronary artery disease in which the difference between concentrations in the coronary sinus and systemic blood was calculated.
Regulation (measured) of E-selectin in coronary sinus associated with angina and coronary artery disease
10) Confidence 0.01 Published 2003 Journal Physiol Res Section Abstract Doc Link 14640893 Disease Relevance 1.24 Pain Relevance 0.56
METHODS: Plasma thrombomodulin levels and the values of the plasma adhesion molecules VCAM-1 (vascular cell adhesion molecule 1), E-selectin (CD62E), and ICAM-1 (intercellular adhesion molecule 1, CD 54) were measured by ELISA during a 7-day period of treatment with orally-administered iloprost in 14 patients with active rheumatoid arthritis.
Regulation (values) of E-selectin in plasma
11) Confidence 0.01 Published 2006 Journal Rheumatol. Int. Section Body Doc Link 15700117 Disease Relevance 0.19 Pain Relevance 0
There were no significant UFP effects on soluble C-reactive protein (CRP) (Figure 2D), E-selectin, L-selectin, CD62P, intercellular cell adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), serum amyloid A (SAA), or the coagulation markers (D-dimer, Factors VII and IX) [see Supplemental Material, Table 6 (doi:10.1289/ehp.1002237)].


Neg (no) Regulation (effects) of E-selectin associated with alzheimer's dementia and adhesions
12) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.37 Pain Relevance 0
, autoantibodies like IgE and IgM has been recorded.[21] Delayed pressure urticaria was diagnosed in 2% as in the literature and is estimated to be between 2-5% and is due to the release of chemo attractant factors with the up-regulation of vascular adhesion molecules, E-selectin and VCAM 1.[22]
Regulation (regulation) of E-selectin associated with urticaria and adhesions
13) Confidence 0.01 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856370 Disease Relevance 0.98 Pain Relevance 0

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