INT64

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Context Info
Confidence 0.14
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.45
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
ear 2
eye 1
dorsal 1
internal 1
dorsal horn 1
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 32 100.00 Very High Very High Very High
Analgesic 2 99.96 Very High Very High Very High
narcan 3 99.80 Very High Very High Very High
opioid receptor 18 99.26 Very High Very High Very High
algil 3 98.96 Very High Very High Very High
Dorsal horn 2 98.80 Very High Very High Very High
Spinal cord 4 97.88 Very High Very High Very High
dexamethasone 3 96.88 Very High Very High Very High
Potency 1 89.76 High High
Inflammation 82 68.64 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 83 100.00 Very High Very High Very High
Pressure And Volume Under Development 93 99.48 Very High Very High Very High
Body Weight 23 95.92 Very High Very High Very High
Weight Gain 1 70.80 Quite High
INFLAMMATION 97 68.64 Quite High
Increased Venous Pressure Under Development 2 68.24 Quite High
Glioma 1 56.92 Quite High
Neuroblastoma 1 56.64 Quite High
Chronic Fatigue Syndrome 83 46.64 Quite Low
Fatigue 12 38.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
where the competing models have the following interpretations model 2 implies that ME causes xi, model 3 implies that the SNP directly affects both xi and ME so that given the SNP they are independent of each other (confounded model), model 4 implies that the SNP and ME both affect xi and model 5 implies that the SNP and xi both affect ME.
Regulation (implies) of ME
1) Confidence 0.14 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0 Pain Relevance 0
Of these, only the t-2-Me, c-6-Me, r-4-OCOMe isomer was an effective analgesic in mice (2.3 X pethidine) as judged by the hot-plate test.
Regulation (effective) of c-6-Me associated with analgesic and algil
2) Confidence 0.13 Published 1976 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6668 Disease Relevance 0 Pain Relevance 0.40
In addition, consistent with a previous report [26], the size of the dLGN ipsilateral to the remaining eye was smaller in ME-treated animals than in control animals (ME, 198,680±15,054 µm2, n?
Regulation (smaller) of ME in eye
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Naloxone reversed ME influence on cell activation.
Regulation (influence) of ME associated with narcan and enkephalin
4) Confidence 0.10 Published 1992 Journal Immunol. Lett. Section Abstract Doc Link 1323526 Disease Relevance 0 Pain Relevance 0.62
Relative to 10 wt% concentration control ME, P. nagi ME significantly reduced edema from 6.4 ± 0.7 to 3.4 ± 1.4, 1 h after TPA addition (47% reduction); no reductions were seen 24 h after TPA addition.
Regulation (control) of ME associated with pressure and volume under development
5) Confidence 0.06 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.73 Pain Relevance 0.07
Preparation of control ME mix for ear edema experiments
Regulation (control) of ME in ear associated with pressure and volume under development
6) Confidence 0.06 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.16 Pain Relevance 0.03
Relative to the same concentration of control ME mix, 20 wt% P. nagi ME reduced ear edema from 17.0 ± 3.3 to 3.4 ± 0.7, 1 h after TPA addition (80% reduction), but did not reduce ear edema 24 h after TPA addition.
Regulation (control) of ME in ear associated with pressure and volume under development
7) Confidence 0.06 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.72 Pain Relevance 0.08
Study III: effects of ME and D&G content of 12 different diets on time of VO in F344 rats
Regulation (content) of ME
8) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137112 Disease Relevance 0.25 Pain Relevance 0
This study defines multiple circadian oscillators with different properties, in brain regions crucial for internal homeostatic regulation including the Arc, ME/PT and ependymal cell layer of the 3rd ventricle and reveals, for the first time, endogenous rhythms in the DMH.
Regulation (regulation) of ME in internal associated with aids-related complex
9) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.41 Pain Relevance 0
These results provide the first ultrastructural evidence that DOR may serve autoreceptor functions on ME terminals as well as presynaptic modulation of other transmitters in the dorsal horn of the rat spinal cord.
Regulation (modulation) of ME in dorsal horn associated with dorsal horn, enkephalin, opioid receptor and spinal cord
10) Confidence 0.03 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7666182 Disease Relevance 0.18 Pain Relevance 1.03
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administration.
Regulation (effects) of N-Me-Phe4 in ventral associated with enkephalin
11) Confidence 0.01 Published 1998 Journal Brain Res. Bull. Section Title Doc Link 9865856 Disease Relevance 0 Pain Relevance 0.47
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administration.
Regulation (effects) of N-Me-Phe4 in dorsal associated with enkephalin
12) Confidence 0.00 Published 1998 Journal Brain Res. Bull. Section Title Doc Link 9865856 Disease Relevance 0 Pain Relevance 0.47

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