INT64030

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 0
Speculated 6
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 4.80
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T lymphocytes 5
spleen 4
mesencephalon 2
dendritic cell 1
Lip 1
Cd8a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 22 99.62 Very High Very High Very High
Multiple sclerosis 11 99.26 Very High Very High Very High
Central grey 15 98.04 Very High Very High Very High
anesthesia 15 93.64 High High
halothane 6 92.80 High High
Inflammatory response 4 91.60 High High
Inflammatory marker 2 89.44 High High
Inflammation 49 88.68 High High
Intracerebroventricular 3 76.20 Quite High
Pain 13 76.08 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 6 99.46 Very High Very High Very High
Multiple Sclerosis 17 99.26 Very High Very High Very High
Urological Neuroanatomy 18 98.04 Very High Very High Very High
Pneumoperitoneum 8 96.52 Very High Very High Very High
INFLAMMATION 49 91.24 High High
Chronic Obstructive Pulmonary Disease 79 89.64 High High
Autoimmune Disease 13 89.64 High High
Cancer 100 86.72 High High
Necrosis 3 86.24 High High
Pain 5 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated CD25, CD4, CD8 expression and CD4/CD8 ratio of systemic and peritoneal T lymphocytes in a rat model.
Spec (investigated) Gene_expression (expression) of CD8 in T lymphocytes
1) Confidence 0.56 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11515680 Disease Relevance 0.27 Pain Relevance 0.08
Phenotypic expression of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+ / CD8+ ) and NK cell ( CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CD8 in spleen
2) Confidence 0.48 Published 2005 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 15898424 Disease Relevance 0.06 Pain Relevance 0
CD8+ IL2R expression was similar in both groups.
Gene_expression (expression) of CD8 in IL2R
3) Confidence 0.44 Published 1998 Journal Surg Endosc Section Body Doc Link 9502703 Disease Relevance 0 Pain Relevance 0
However, no significant differences in systemic CD4/CD8 ratio or peritoneal or systemic CD25 expression were found between the different operative groups.
Gene_expression (expression) of CD8
4) Confidence 0.44 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11515680 Disease Relevance 0.24 Pain Relevance 0.09
Phenotypic expressions of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+/ CD8+) and NK cell(CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expressions) of CD8 in spleen
5) Confidence 0.40 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18544843 Disease Relevance 0 Pain Relevance 0
Phenotypic expression of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+ / CD8+ ) and NK cell ( CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CD8 in spleen
6) Confidence 0.37 Published 2005 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 15898424 Disease Relevance 0.06 Pain Relevance 0
Phenotypic expressions of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+/ CD8+) and NK cell(CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expressions) of CD8 in spleen
7) Confidence 0.35 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18544843 Disease Relevance 0 Pain Relevance 0
Furthermore, morphine did not alter the expression of CD3, CD4, CD8, and NKR-P1 surface markers, but significantly (p < 0.001) downregulated the expression of CD25 and CD71 receptors following in vitro activation.
Gene_expression (expression) of CD8 in CD3 associated with morphine
8) Confidence 0.30 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.39 Pain Relevance 0.71
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Gene_expression (expression) of CD8 in mesencephalon associated with central grey and morphine
9) Confidence 0.30 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.57
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Gene_expression (expression) of CD8 in mesencephalon associated with central grey and morphine
10) Confidence 0.30 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.59
The ability of T lymphocytes to express both the CD8 and CD25 (IL-2) receptors in response to PHA were suppressed.
Gene_expression (express) of CD8 in T lymphocytes
11) Confidence 0.22 Published 1996 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 8771374 Disease Relevance 0 Pain Relevance 0.54
Additionally, SNC 80 did not significantly affect splenic T cell or natural killer cell populations as measured by the expression of T cell receptoralphabeta, and T helper (CD4), T suppressor/cytotoxic (CD8) and natural killer cell surface markers.
Gene_expression (expression) of CD8 in T cell
12) Confidence 0.21 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694952 Disease Relevance 0.25 Pain Relevance 0.25
Cellularity and dendritic cell content in DLNC population, as well as the expression of TCR-alpha, CD4, CD8 and CD25, were not changed between irradiated and nonirradiated animals.
Gene_expression (expression) of CD8 in dendritic cell
13) Confidence 0.18 Published 2003 Journal Photodermatol Photoimmunol Photomed Section Body Doc Link 12925192 Disease Relevance 0 Pain Relevance 0
So were the CD4+/CD8+ ratios in all medicated groups.
Gene_expression (ratios) of CD8
14) Confidence 0.18 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.30 Pain Relevance 0.07
l of fluorescent monoclonal antibodies against CD3, CD4, CD8 and CD161a (Pharmingen, Becton Dickinson, USA) to 100 ?
Gene_expression (antibodies) of CD8
15) Confidence 0.18 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.06 Pain Relevance 0.11
Increased CD4+ and CD8+ cell counts and an elevation of CD8+:CD4+ ratio are also observed.
Gene_expression (counts) of CD8
16) Confidence 0.16 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.56 Pain Relevance 0.13
200) (Serotec) to visualise major histocompatibility class II molecules; mouse monoclonal anti-CD8 (1?
Gene_expression (molecules) of CD8
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.23 Pain Relevance 0.04
Cells expressing CD8 were also observed to be adjacent to Rh-Lip-bearing macrophages (Figure 2D).
Gene_expression (expressing) of CD8 in Lip
18) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
The expression of CD25 and CD54 on CD4+, and CD8+ lymphocytes in pulp tissues was determined by using a flow cytometer.
Spec (determined) Gene_expression (expression) of CD8 in lymphocytes
19) Confidence 0.07 Published 2002 Journal J Endod Section Abstract Doc Link 12017181 Disease Relevance 0.32 Pain Relevance 0.19
Cells were identified as follows: Lymphocytes low FSC, low SSC, no autofluorescence, and expressing either CD45RA+ (B-lymphocytes), CD5+ (T-lymphocytes), CD5+CD4+ (helper T-lymphocytes), and CD5+CD8+ (cytotoxic T-lymphocytes); neutrophils low FSC, intermediate SSC and HIS48+; macrophages as high SSC and FSC and autofluorescent [34].
Gene_expression (expressing) of CD8 in helper T-lymphocytes associated with hypersensitivity
20) Confidence 0.05 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.39 Pain Relevance 0

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