INT64044

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.27
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DAG1) extracellular space (DAG1) extracellular region (DAG1)
plasma membrane (DAG1) cytoskeleton (DAG1) nucleus (DAG1)
Anatomy Link Frequency
neutrophil 1
DAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
Enkephalin 8 98.28 Very High Very High Very High
Opioid 2 83.64 Quite High
Intracerebroventricular 2 67.96 Quite High
COX2 1 48.56 Quite Low
ketamine 4 25.60 Quite Low
antagonist 38 5.00 Very Low Very Low Very Low
imagery 24 5.00 Very Low Very Low Very Low
agonist 24 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4 82.04 Quite High
Fungal Infection 38 63.08 Quite High
Hypertension 1 51.12 Quite High
Stress 12 42.48 Quite Low
Natriuresis 1 35.76 Quite Low
Body Weight 2 19.92 Low Low
Sprains And Strains 12 17.76 Low Low
Infection 66 5.00 Very Low Very Low Very Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Candida Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MENK induced O2- release was associated with a dose-dependent increase of diacylglycerol (DAG) concentration and protein-kinase C (PKC) translocation to the neutrophil membranes, with an increase of cytosolic Ca++, and could be abolished by H7, a PKC inhibitor.
Localization (translocation) of DAG in neutrophil associated with kinase c and enkephalin
1) Confidence 0.59 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8771562 Disease Relevance 0 Pain Relevance 0.83
We also found that two other DAG species (18:0/18:1 and Di C18:0) followed the same pattern observed for DAG 18:0/20:4 (data not shown).
Localization (observed) of DAG
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.06 Pain Relevance 0
SM, ceramide and DAG determination
Localization (determination) of DAG
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
q11)-coupled receptor family and is coupled to PLC, which controls the generation of InsP3 and diacylglycerol (DAG), which, in turn, leads to the liberation of Ca2+ from intracellular stores and the activation of protein kinases type C (PKC), respectively.
Localization (liberation) of DAG
4) Confidence 0.05 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

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