INT64048

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 21.24
Pain Relevance 13.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
plasma 11
dorsal root ganglia 10
spinal cord 4
microglias 4
brain 3
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 63 100.00 Very High Very High Very High
allodynia 53 100.00 Very High Very High Very High
dorsal root ganglion 25 100.00 Very High Very High Very High
spinal dorsal horn 18 100.00 Very High Very High Very High
Neuropathic pain 33 99.98 Very High Very High Very High
Morphine 12 99.68 Very High Very High Very High
Peripheral nerve injury 2 99.38 Very High Very High Very High
tolerance 7 99.32 Very High Very High Very High
Pain 35 99.16 Very High Very High Very High
Multiple sclerosis 4 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 91 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Cancer 45 100.00 Very High Very High Very High
Ganglion Cysts 25 100.00 Very High Very High Very High
Urological Neuroanatomy 10 100.00 Very High Very High Very High
Diabetes Mellitus 50 99.98 Very High Very High Very High
Multiple Sclerosis 1 99.98 Very High Very High Very High
Nervous System Injury 6 99.38 Very High Very High Very High
Demyelinating Disease 4 98.84 Very High Very High Very High
Stress 10 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, accumulation of mRNA specific for TNFalpha is significantly increased in neurons within a region of the brain containing the locus coeruleus at days 2, 8, and 14 postligature placement, contemporaneous with the development of hyperalgesia.
Positive_regulation (increased) of Positive_regulation (accumulation) of TNFalpha in locus coeruleus
1) Confidence 0.70 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0 Pain Relevance 0
Axotomy-induced up-regulation of tumor necrosis factor-alpha in the dorsal root ganglia.
Positive_regulation (Axotomy-induced) of Positive_regulation (regulation) of tumor necrosis factor-alpha in dorsal root ganglia associated with necrosis and cancer
2) Confidence 0.50 Published 2008 Journal Neurol. Res. Section Title Doc Link 18489817 Disease Relevance 0.94 Pain Relevance 0.53
Injection of LPS (i) induced biphasic changes of blood glucose and rectal temperature: an initial increased phase (<180 min after injection of LPS) followed by a decreased phase (at 240 or 360 min), (ii) caused a significant fall in mean arterial blood pressure from 119+/-3 mmHg (at time 0) to 73+/-67 mmHg (at 360 min) with a concomitant increase of heart rate, (iii) resulted in a substantial hyporeactivity to norepinephrine (NE) (1 microg/kg i.v.), (iv) increased plasma nitrate (an indicator of NO formation) in a time-dependent manner, and (v) induced bell-shape changes in plasma TNF-alpha levels which reached a peak at 60 min.
Positive_regulation (induced) of Positive_regulation (changes) of TNF-alpha in plasma
3) Confidence 0.50 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10707896 Disease Relevance 0.45 Pain Relevance 0
These data suggest that the upregulation of TNF-alpha and TNFR1 in DRG and spinal dorsal horn is essential for the initiation but not for maintenance of the neuropathic pain induced by L5 VRT.
Neg (not) Positive_regulation (essential) of Positive_regulation (upregulation) of TNF-alpha in DRG associated with dorsal root ganglion, spinal dorsal horn and neuropathic pain
4) Confidence 0.50 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.09 Pain Relevance 0.88
The increased TNF-alpha-IR in spinal dorsal horn was observed in astrocytes, microglias and neurons, but the upregulation of TNFR1 was mainly in neurons.
Positive_regulation (upregulation) of Positive_regulation (increased) of TNF-alpha-IR in microglias associated with spinal dorsal horn
5) Confidence 0.50 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.23 Pain Relevance 0.94
Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway.
Positive_regulation (induces) of Positive_regulation (upregulation) of TNF-alpha in dorsal root ganglia associated with pain, allodynia and spinal dorsal horn
6) Confidence 0.49 Published 2007 Journal Exp. Neurol. Section Title Doc Link 17459378 Disease Relevance 0.46 Pain Relevance 0.50
Similar to other studies, we showed that injurious MV strategies increased the concentrations of TNF-?
Positive_regulation (increased) of Positive_regulation (concentrations) of TNF
7) Confidence 0.49 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.63 Pain Relevance 0.23
Sherry et al demonstrate that p38 also mediates augmented lipopolysaccharide induced TNF-?
Positive_regulation (augmented) of Positive_regulation (induced) of TNF
8) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.15 Pain Relevance 0.61
On the contrary, propranolol, a beta-receptor blocker, induced a highly significant 3-fold increase in plasma TNF-alpha concentrations at 30 min and augmented the response to LPS 2-fold after endotoxin injection.
Positive_regulation (induced) of Positive_regulation (increase) of TNF-alpha in plasma
9) Confidence 0.48 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11752888 Disease Relevance 0 Pain Relevance 0
CONCLUSION: (1) Both neurogenic and systemic stressors lower basal plasma LH and T levels and blunt the T response to hCG. (2) LPS, whose ability to release ACTH and corticosterone was similar to that of shocks, but caused increases in circulating TNF-alpha and IL-6 levels that were significantly larger than those due to the other stressors, was the most potent inhibitor of the T response to hCG. (3) Neither beta-adrenergic nor opiate receptors play a major role in the ability of the stressors we used to inhibit T release.


Positive_regulation (caused) of Positive_regulation (increases) of TNF-alpha in plasma
10) Confidence 0.48 Published 2002 Journal Neuroimmunomodulation Section Body Doc Link 12207160 Disease Relevance 0 Pain Relevance 0
However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization.
Positive_regulation (potentiated) of Positive_regulation (induced) of TNF-alpha associated with necrosis, cancer, tolerance and morphine
11) Confidence 0.48 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.37 Pain Relevance 0.71
However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization.
Positive_regulation (potentiated) of Positive_regulation (induced) of tumor necrosis factor-alpha associated with necrosis, cancer, tolerance and morphine
12) Confidence 0.48 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.37 Pain Relevance 0.71
CONCLUSIONS: The increases in TNFalpha within regions of the brain and spinal cord that are associated with adrenergic neuron function, as well as with modulation of pain perception, and the time course and distribution of the increases in TNFalpha accumulation support a neuromodulatory role for TNFalpha within the CNS in the development and maintenance of neuropathic pain.


Positive_regulation (increases) of Positive_regulation (accumulation) of TNFalpha in brain
13) Confidence 0.47 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0 Pain Relevance 0
Recently, increased plasma levels of tumor necrosis factor-alpha (TNF-alpha), which can increase leukocyte adherence, have been reported after administration of indomethacin.
Positive_regulation (increase) of Positive_regulation (increased) of TNF-alpha in plasma associated with necrosis and cancer
14) Confidence 0.47 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772499 Disease Relevance 0.59 Pain Relevance 0.39
Experimental autoimmune encephalomyelitis-induced upregulation of tumor necrosis factor-alpha in the dorsal root ganglia.
Positive_regulation (induced) of Positive_regulation (upregulation) of tumor necrosis factor-alpha in dorsal root ganglia associated with pain, necrosis and cancer
15) Confidence 0.46 Published 2009 Journal Mult. Scler. Section Title Doc Link 19667008 Disease Relevance 1.15 Pain Relevance 0.91
Both oxicams produced a similar extent of the gastric mucosal damage and a significant decrease in PGE2 synthesis, however only piroxicam induced an increase of both myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha content in the gastric mucosa, indicating that neutrophil-derived free radicals were involved in gastric injury.
Positive_regulation (induced) of Positive_regulation (increase) of TNF in neutrophil associated with necrosis, cancer, injury and urological neuroanatomy
16) Confidence 0.45 Published 2002 Journal Free Radic. Res. Section Abstract Doc Link 12180128 Disease Relevance 0.63 Pain Relevance 0.22
Furthermore, baicalin dose-dependently attenuated tumor necrosis factor-alpha (from 3510 +/- 150 pg/mL to 2860 +/- 148 pg/mL to 1480 +/- 210 pg/mL), interleukin (IL)-1beta (from 3210 +/- 210 pg/mL to 2200 +/- 140 pg/mL to 750 +/- 95 pg/mL), and IL-6 (from 58.5 +/- 9.8 pg/mL to 38.5 +/- 9.0 to 21.0 +/- 8.1 ng/mL) formation but enhanced IL-10 (from 18.1 +/- 2.5 pg/mL to 36.1 +/- 5.5 pg/mL to 71.2 +/- 9.5 pg/mL) production in paw exudates at 4 h after carrageenan injection.
Positive_regulation (attenuated) of Positive_regulation (formation) of tumor necrosis factor-alpha in paw associated with necrosis and cancer
17) Confidence 0.39 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633550 Disease Relevance 0.53 Pain Relevance 0.43
This increase of both TNF-alpha and nitrate levels induced by lipopolysaccharide was significantly reduced in lipopolysaccharide-rats pretreated with pentoxifylline.
Positive_regulation (induced) of Positive_regulation (increase) of TNF-alpha
18) Confidence 0.34 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408250 Disease Relevance 0.14 Pain Relevance 0.12
This increase of both TNF-alpha and nitrate levels induced by lipopolysaccharide was significantly reduced in lipopolysaccharide-rats pretreated with pentoxifylline.
Positive_regulation (increase) of Positive_regulation (induced) of TNF-alpha
19) Confidence 0.34 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408250 Disease Relevance 0.14 Pain Relevance 0.12
In a separate group of rats, interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha (TNF-alpha) and cytokine-induced neutrophil chemoattractant (CINC-1) concentrations were measured in plasma and tail tissue samples taken at the site of injection, 3 h, 6 h and 24 h after injections.
Positive_regulation (measured) of Positive_regulation (cytokine-induced) of TNF-alpha in plasma associated with necrosis, cancer and cytokine
20) Confidence 0.31 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17692348 Disease Relevance 0.88 Pain Relevance 0.64

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