INT6405

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 4.79
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Enpep) peptidase activity (Enpep) plasma membrane (Enpep)
Anatomy Link Frequency
skin 2
blood 1
plasma 1
liver 1
lymphocytes 1
Enpep (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 26 100.00 Very High Very High Very High
Paracetamol 14 100.00 Very High Very High Very High
transdermal 2 95.96 Very High Very High Very High
Dismenorea 18 88.32 High High
Cholecystokinin 2 87.12 High High
agonist 18 85.28 High High
antagonist 48 81.56 Quite High
Central nervous system 4 81.12 Quite High
Eae 4 80.48 Quite High
Pain 2 77.28 Quite High
Disease Link Frequency Relevance Heat
Pre-eclampsia 414 99.44 Very High Very High Very High
Hypertension 247 99.00 Very High Very High Very High
Pre-term Labor 243 97.84 Very High Very High Very High
Proteinuria 36 96.44 Very High Very High Very High
Increased Venous Pressure Under Development 27 96.04 Very High Very High Very High
Dysmenorrhea 18 88.32 High High
Malaria 2 85.24 High High
Bacterial Meningitis 2 82.80 Quite High
Pressure Volume 2 Under Development 27 82.40 Quite High
Pain 2 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarities in substrate kinetic values (Km and Vmax) and substrate specificity of the enzyme(s) in homogenates prepared from neonatal mouse skin epidermis and cultured mouse keratinocytes strongly suggest that the keratinocytes in culture express the same aminopeptidase(s) with the same relative activity as in neonatal skin.
Gene_expression (express) of aminopeptidase in skin
1) Confidence 0.67 Published 1991 Journal Pharm. Res. Section Abstract Doc Link 2014210 Disease Relevance 0 Pain Relevance 0.18
To define this metabolic activity, aminopeptidase activity and Leu-enkephalin metabolism were measured in the epidermis obtained from neonatal mouse skin and in cultured mouse keratinocytes.
Gene_expression (metabolism) of aminopeptidase in epidermis associated with enkephalin
2) Confidence 0.58 Published 1991 Journal Pharm. Res. Section Abstract Doc Link 2014210 Disease Relevance 0 Pain Relevance 0.15
It exerts a direct stimulating effect on lymphocytes (and monocytes) via its fixation on cell surface leucine-aminopeptidase, and an indirect effect on monocytes (and lymphocytes) via aminopeptidase B inhibition of tuftsin catabolism.
Gene_expression (fixation) of aminopeptidase in lymphocytes
3) Confidence 0.53 Published 1991 Journal Biomed. Pharmacother. Section Abstract Doc Link 1912369 Disease Relevance 0.22 Pain Relevance 0.05
These metabolites are products of the two major enkephalin hydrolyzing enzymes in plasma, aminopeptidase and angiotensin converting enzyme.
Gene_expression (products) of aminopeptidase in plasma associated with enkephalin
4) Confidence 0.40 Published 1988 Journal Life Sci. Section Abstract Doc Link 3412113 Disease Relevance 0 Pain Relevance 0.89
Thus, the trophoblastic degeneration seen during severe preeclampsia may be due to a failure to synthesize APA and P-LAP.
Gene_expression (synthesize) of APA associated with pre-eclampsia
5) Confidence 0.32 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.84 Pain Relevance 0.09
We have shown that progesterone, and probably estrogen, increases APA levels in human trophoblastic cells.
Gene_expression (levels) of APA
6) Confidence 0.32 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.59 Pain Relevance 0
They also showed that treatment with an ACE inhibitor reduced kidney APA activity in SHRs, suggesting that APA expression may be positively coupled with AngII levels.
Gene_expression (expression) of APA in kidney
7) Confidence 0.32 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0 Pain Relevance 0.04
Maternal serum APA and P-LAP activities in early mild preeclampsia patients are higher than those seen in normal pregnancy patients [42, 43].
Gene_expression (activities) of APA associated with pre-eclampsia
8) Confidence 0.32 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.55 Pain Relevance 0.12
Much higher doses of APA revealed a sharp decline of BP (approximately 50?
Gene_expression (doses) of APA
9) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.12 Pain Relevance 0
The antihypertensive effects induced by a bolus injection of APA (0.016?
Gene_expression (injection) of APA
10) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.31 Pain Relevance 0
Bolus injections of APA and ARB were administered via osmotic minipumps.
Gene_expression (injections) of APA
11) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.68 Pain Relevance 0.03
We compared the antihypertensive effects of daily bolus injections of APA (0.016?
Gene_expression (injections) of APA
12) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.24 Pain Relevance 0
RB 101 is a recently reported systemically active mixed inhibitor prodrug of the two enzymes which metabolize the enkephalins neutral endopeptidase 24.11 and aminopeptidase N.
Gene_expression (metabolize) of aminopeptidase associated with enkephalin
13) Confidence 0.20 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1327810 Disease Relevance 0 Pain Relevance 0.63
However the aminopeptidase structures from N. meningitidis, E. coli and P. falciparum also have a ?
Gene_expression (structures) of aminopeptidase
14) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0.17 Pain Relevance 0
For example mammalian APA cleaves brain angiotensin II to yield angiotensin III, and is thus implicated in the control of arterial blood pressure [55].
Gene_expression (cleaves) of APA in blood
15) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0.15 Pain Relevance 0.19
During normal pregnancy, sufficient levels of P-LAP degrade OT and AVP, and APA deactivates AngII, thus protecting the mother.
Gene_expression (degrade) of APA
16) Confidence 0.14 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.93 Pain Relevance 0.07
The formation of DCBN- or AP-protein adducts and other AP metabolites, including 3-hydroxy-AP and, in the presence of glutathione, AP-glutathione conjugate, was also detected in OM microsomal reactions and to a much greater extent than in liver microsomes.
Gene_expression (formation) of AP-glutathione in liver associated with paracetamol
17) Confidence 0.03 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618435 Disease Relevance 0 Pain Relevance 0.96

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