INT64051

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 36
Disease Relevance 10.10
Pain Relevance 17.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Col4a4) cellular_component (Col4a4) biological_process (Col4a4)
Anatomy Link Frequency
small intestine 4
dorsal 3
brain 2
Plasma 1
spinal nerve 1
Col4a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 100.00 Very High Very High Very High
Raphe 15 99.44 Very High Very High Very High
agonist 23 99.28 Very High Very High Very High
Dorsal horn 7 99.20 Very High Very High Very High
Nicotine 49 99.00 Very High Very High Very High
GABAergic 11 98.80 Very High Very High Very High
qutenza 55 98.54 Very High Very High Very High
Spinal cord 12 98.40 Very High Very High Very High
Peripheral nerve injury 4 98.24 Very High Very High Very High
antinociception 27 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 27 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 5 98.60 Very High Very High Very High
Nervous System Injury 6 98.24 Very High Very High Very High
Urological Neuroanatomy 21 97.56 Very High Very High Very High
Fistula 10 97.56 Very High Very High Very High
Targeted Disruption 10 96.60 Very High Very High Very High
Nociception 10 95.60 Very High Very High Very High
Aging 3 92.96 High High
Appetite Loss 5 92.64 High High
Convulsion 7 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have very recently shown that intracisternal injection of apolipoprotein A-IV (apo A-IV), a glycoprotein produced in the small intestine by fat, dose-dependently inhibited gastric acid secretion in pylorus-ligated conscious rats.
Gene_expression (produced) of A-IV in small intestine associated with disorder of lipid metabolism
1) Confidence 0.61 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772500 Disease Relevance 0.17 Pain Relevance 0.10
We have very recently shown that intracisternal injection of apolipoprotein A-IV (apo A-IV), a glycoprotein produced in the small intestine by fat, dose-dependently inhibited gastric acid secretion in pylorus-ligated conscious rats.
Gene_expression (produced) of A-IV in small intestine associated with disorder of lipid metabolism
2) Confidence 0.61 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772500 Disease Relevance 0.17 Pain Relevance 0.10
We tested the hypothesis that stimulation of synthesis and secretion of intestinal apolipoprotein A-IV (apo A-IV) by intestinally infused lipid is mediated by capsaicin-sensitive afferent signals.
Gene_expression (synthesis) of A-IV associated with qutenza and disorder of lipid metabolism
3) Confidence 0.57 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321877 Disease Relevance 0.25 Pain Relevance 0.39
We tested the hypothesis that stimulation of synthesis and secretion of intestinal apolipoprotein A-IV (apo A-IV) by intestinally infused lipid is mediated by capsaicin-sensitive afferent signals.
Gene_expression (synthesis) of A-IV associated with qutenza and disorder of lipid metabolism
4) Confidence 0.57 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321877 Disease Relevance 0.25 Pain Relevance 0.39
In separate studies the effect of capsaicin treatment on ileal lipid-elicited stimulation of intestinal mucosal apo A-IV synthesis was also examined.
Gene_expression (synthesis) of A-IV associated with qutenza
5) Confidence 0.51 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321877 Disease Relevance 0.33 Pain Relevance 0.66
Ileal lipid infusion increased apo A-IV synthesis in distal ileum, proximal jejunum, and jejunal Thirty-Vella fistulas; this finding was unaffected by capsaicin pretreatment.
Gene_expression (synthesis) of A-IV in ileum associated with fistula and qutenza
6) Confidence 0.51 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321877 Disease Relevance 0.33 Pain Relevance 0.67
Since apo A-IV synthesis in the enterocytes is linked to the intracellular assembly of lipoprotein, it is likely that in addition to lymphatic transport, production of chylomicrons is not impaired in ageing rats.
Gene_expression (synthesis) of A-IV in enterocytes associated with aging and disorder of lipid metabolism
7) Confidence 0.50 Published 2000 Journal Mech. Ageing Dev. Section Abstract Doc Link 10714940 Disease Relevance 0.44 Pain Relevance 0.09
Apolipoprotein A-IV (apo A-IV), a peptide expressed by enterocytes in the mammalian small intestine and released in response to long-chain triglyceride absorption, may be involved in the regulation of gastric acid secretion and gastric motility.
Gene_expression (expressed) of A-IV in small intestine associated with disorder of lipid metabolism
8) Confidence 0.29 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15117731 Disease Relevance 0.23 Pain Relevance 0
Apolipoprotein A-IV (apo A-IV), a peptide expressed by enterocytes in the mammalian small intestine and released in response to long-chain triglyceride absorption, may be involved in the regulation of gastric acid secretion and gastric motility.
Gene_expression (expressed) of A-IV in small intestine associated with disorder of lipid metabolism
9) Confidence 0.29 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15117731 Disease Relevance 0.23 Pain Relevance 0
These results indicate that toluene exposure during the brain growth spurt produces long-term changes in nicotine sensitivity, which may be unrelated to the total expression levels of alpha4, alpha7, and beta2 nicotinic receptors.
Gene_expression (expression) of alpha4 in brain associated with nicotine
10) Confidence 0.25 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.32 Pain Relevance 0.47
The specific aim of the present study was to determine the pathway involved in mediating inhibition of gastric motility produced by apo A-IV.
Gene_expression (produced) of A-IV
11) Confidence 0.25 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15117731 Disease Relevance 0.25 Pain Relevance 0.03
These results indicate that toluene exposure during the brain growth spurt produces long-term changes in nicotine sensitivity, which may be unrelated to the total expression levels of alpha4, alpha7, and beta2 nicotinic receptors.
Gene_expression (levels) of alpha4 in brain associated with nicotine
12) Confidence 0.20 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.32 Pain Relevance 0.46
However, the levels of alpha4, alpha7, and beta2 nicotinic receptors were not altered in the frontal cortex, striatum, thalamus, hippocampus, and cerebellum by neonatal toluene exposure.
Gene_expression (levels) of alpha4 in hippocampus associated with urological neuroanatomy, hippocampus and thalamus
13) Confidence 0.20 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.36 Pain Relevance 0.47
Accompanying the loss of terminals and nicotinic binding sites were significant reductions in the expression of alpha 3, alpha 4, alpha 5, beta 2 and beta 4 nicotinic receptor subunits in the superficial layers of the spinal cord as determined by antibody staining and confocal microscopy.
Gene_expression (expression) of alpha 4 in spinal cord associated with spinal cord
14) Confidence 0.17 Published 2004 Journal J. Neurocytol. Section Abstract Doc Link 15906161 Disease Relevance 0.39 Pain Relevance 0.75
Ileal lipid infusion increased apo A-IV synthesis in distal ileum, proximal jejunum, and jejunal Thirty-Vella fistulas; this finding was unaffected by capsaicin pretreatment.
Gene_expression (synthesis) of A-IV in proximal associated with fistula and qutenza
15) Confidence 0.17 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321877 Disease Relevance 0.33 Pain Relevance 0.67
However, the levels of alpha4, alpha7, and beta2 nicotinic receptors were not altered in the frontal cortex, striatum, thalamus, hippocampus, and cerebellum by neonatal toluene exposure.
Gene_expression (levels) of alpha4 in cerebellum associated with urological neuroanatomy, hippocampus and thalamus
16) Confidence 0.07 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.36 Pain Relevance 0.47
However, the levels of alpha4, alpha7, and beta2 nicotinic receptors were not altered in the frontal cortex, striatum, thalamus, hippocampus, and cerebellum by neonatal toluene exposure.
Gene_expression (levels) of alpha4 in thalamus associated with urological neuroanatomy, hippocampus and thalamus
17) Confidence 0.07 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.36 Pain Relevance 0.47
However, the levels of alpha4, alpha7, and beta2 nicotinic receptors were not altered in the frontal cortex, striatum, thalamus, hippocampus, and cerebellum by neonatal toluene exposure.
Gene_expression (levels) of alpha4 in frontal cortex associated with urological neuroanatomy, hippocampus and thalamus
18) Confidence 0.07 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.36 Pain Relevance 0.47
However, the levels of alpha4, alpha7, and beta2 nicotinic receptors were not altered in the frontal cortex, striatum, thalamus, hippocampus, and cerebellum by neonatal toluene exposure.
Gene_expression (levels) of alpha4 in striatum associated with urological neuroanatomy, hippocampus and thalamus
19) Confidence 0.07 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 17951610 Disease Relevance 0.36 Pain Relevance 0.47
In the presence of TTX, DHPG, DCG-IV and L-AP4 all reduced the frequency of spontaneous miniature IPSCs, but had no effect on their amplitudes.
Gene_expression (presence) of DCG-IV
20) Confidence 0.04 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15081789 Disease Relevance 0.40 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox