INT64052

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 30
Disease Relevance 28.47
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FGFR1) extracellular region (FGFR1) cytoplasmic membrane-bounded vesicle (FGFR1)
plasma membrane (FGFR1) nucleus (FGFR1) cytoplasm (FGFR1)
Anatomy Link Frequency
fibroblast 5
pericardial fluid 3
astrocytes 2
neural 1
blood 1
FGFR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 20 100.00 Very High Very High Very High
Angina 13 100.00 Very High Very High Very High
cytokine 208 99.38 Very High Very High Very High
Inflammation 238 99.20 Very High Very High Very High
agonist 124 98.76 Very High Very High Very High
COX2 108 98.22 Very High Very High Very High
Enkephalin 22 97.20 Very High Very High Very High
ischemia 171 95.48 Very High Very High Very High
Hippocampus 85 94.84 High High
dorsal root ganglion 4 93.68 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 13 100.00 Very High Very High Very High
Stress 622 99.92 Very High Very High Very High
Manic Depressive Disorder 13 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 66 99.72 Very High Very High Very High
Neurodegenerative Disease 142 99.68 Very High Very High Very High
Infection 34 99.40 Very High Very High Very High
Cancer 153 99.32 Very High Very High Very High
INFLAMMATION 246 99.20 Very High Very High Very High
Disease 332 98.84 Very High Very High Very High
Eosinophilic Esophagitis 318 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia.
Positive_regulation (increased) of basic fibroblast growth factor in pericardial fluid associated with angina, coronary artery disease and ischemia
1) Confidence 0.52 Published 1998 Journal Angiogenesis Section Abstract Doc Link 14517380 Disease Relevance 0.54 Pain Relevance 0.43
Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.
Positive_regulation (elevation) of basic fibroblast growth factor in pericardial fluid associated with angina
2) Confidence 0.52 Published 1998 Journal Angiogenesis Section Title Doc Link 14517380 Disease Relevance 0.69 Pain Relevance 0.52
For example several growth factors (AREG, VEGF, FGFR1) were upregulated three hours after exposure to the high concentration of curcumin (Table 2).
Positive_regulation (upregulated) of FGFR1
3) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.06 Pain Relevance 0
FGFR1 and IGF1 (insulin-like growth factor 1) were elevated in an animal model of mania [20].
Positive_regulation (elevated) of FGFR1 associated with manic depressive disorder
4) Confidence 0.21 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.97 Pain Relevance 0.26
Given that many genes are likely to be irrelevant to the biological processes underlying the brachial plexus injuries and hence are expected to show little difference in their expression levels between injured patients and control subjects, it is not surprising that no significant result was obtained for t-SAM when applying the complete data set.
Neg (no) Positive_regulation (result) of t-SAM in brachial plexus associated with injury
5) Confidence 0.21 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0.10 Pain Relevance 0
Panutsopulos D et al. were also able to demonstrate an impairment of monocyte migration with an associated increase in basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) mRNA [39].
Positive_regulation (increase) of basic fibroblast growth factor in monocyte
6) Confidence 0.19 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 0.95 Pain Relevance 0.22
Several other redox-sensitive genes were upregulated after short-term exposure to the high concentration of curcumin, like AREG, ATF4, EGR1, FGFR1 (Table 2) [44].
Positive_regulation (upregulated) of FGFR1
7) Confidence 0.18 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.17 Pain Relevance 0.05
Additionally, increases in basic fibroblast growth factor were found to be associated with activation of anti-apoptotic pathways.
Positive_regulation (increases) of basic fibroblast growth factor in fibroblast associated with apoptosis
8) Confidence 0.08 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.12 Pain Relevance 0.05
This group, termed P-neurons after their "pear" shape, sequentially required nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) for survival in vitro during different developmental stages.
Positive_regulation (required) of bFGF in nerve associated with nerve growth factor
9) Confidence 0.08 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11698599 Disease Relevance 0.26 Pain Relevance 0.56
OGD induced neuroblast activation
Positive_regulation (activation) of OGD in neuroblast
10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.22 Pain Relevance 0.03
Levels slightly increased only 5 days after OGD.
Positive_regulation (increased) of OGD
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.10 Pain Relevance 0.07
Our model reproduces previously published data in which neurogenesis is transiently activated after OGD with a peak of DCX+ cells observed in the damaged cortex, 5 days after the insult.
Positive_regulation (activated) of OGD in cortex associated with neurodegenerative disease
12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.39 Pain Relevance 0
Elevated basic fibroblast growth factor in pericardial fluid of patients with unstable angina.
Positive_regulation (Elevated) of basic fibroblast growth factor in pericardial fluid associated with angina
13) Confidence 0.06 Published 1996 Journal Circulation Section Title Doc Link 8772678 Disease Relevance 0.10 Pain Relevance 0.14
Of the transcripts tested for possible immune indicators, we found extracellular signal-regulated kinase (ERK), Bcl-2, bFGF (basic fibroblast growth factor), and eotaxin levels were highly upregulated in PBMC and associated with disease presence of EoE.
Positive_regulation (upregulated) of basic fibroblast growth factor in fibroblast associated with disease and eosinophilic esophagitis
14) Confidence 0.06 Published 2010 Journal Allergy Asthma Clin Immunol Section Abstract Doc Link PMC2976489 Disease Relevance 1.74 Pain Relevance 0.07
Subjects with eosinophilic esophagitis had different immune indicator profiles, specifically with increases in basic fibroblast growth factor in blood plasma, peripheral blood mononuclear cells, and local esophageal tissue compared to subjects with gastroesophageal reflux disease, ulcerative colitis, Crohn's disease, and healthy controls.
Positive_regulation (increases) of basic fibroblast growth factor in blood associated with inflammatory bowel disease, crohn's disease, gastroesophageal reflux disease, disease and eosinophilic esophagitis
15) Confidence 0.06 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.78 Pain Relevance 0.05
Analysis of IBC tumor cell lines and archival tumor specimens demonstrated that high levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor, IL-6, and IL-8 are expressed and secreted by the tumor cells (unpublished data).
Positive_regulation (levels) of basic fibroblast growth factor in fibroblast associated with inflammatory breast neoplasms and cancer
16) Confidence 0.04 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.98 Pain Relevance 0.31
-AR activation in both pure OGD and in the combined insult LPS+OGD in slices devoid of TNFR1 suggests that ?
Positive_regulation (activation) of OGD
17) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.37 Pain Relevance 0.16
Also, COX 2 was reported to be a key enzyme for inflammatory cytokine-induced angiogenesis, and the upregulation of vascular endothelial growth factor, basic fibroblast growth factor, and nitric oxide synthases, which are associated with tumor formation [16,17].
Positive_regulation (upregulation) of basic fibroblast growth factor in fibroblast associated with inflammation, cancer, cox2 and cytokine
18) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669508 Disease Relevance 0.87 Pain Relevance 0.57
Moreover, the aforedescribed findings regarding the effects of COX 2 in cutaneous tumor formation have also been reported in pterygium, including disruption of apoptosis [3,18], limbal epithelial proliferation [19], abnormal p53 gene expression [1-5], and upregulation of basic fibroblast growth factor [20], vascular endothelial growth factor, and nitric oxide synthases [21].
Positive_regulation (upregulation) of basic fibroblast growth factor in fibroblast associated with conjunctiva disease, cancer, cox2 and apoptosis
19) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669508 Disease Relevance 0.99 Pain Relevance 0.40
-agonists in equi-molar concentrations on cytokine secretion during LPS exposure and following LPS + OGD were similar.


Positive_regulation (following) of OGD in molar associated with agonist and cytokine
20) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.15 Pain Relevance 0.40

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