INT64054

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 9.33
Pain Relevance 9.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tmprss11d) extracellular region (Tmprss11d) plasma membrane (Tmprss11d)
Anatomy Link Frequency
liver 3
plasma 1
blood 1
fat 1
Tmprss11d (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 123 99.98 Very High Very High Very High
Morphine 7 99.44 Very High Very High Very High
anesthesia 3 95.76 Very High Very High Very High
Analgesic 2 94.32 High High
cytokine 13 93.64 High High
cva 12 92.08 High High
bradykinin 2 84.96 Quite High
antagonist 2 73.08 Quite High
Pain 3 60.72 Quite High
ischemia 3 32.24 Quite Low
Disease Link Frequency Relevance Heat
Stress 19 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 12 99.72 Very High Very High Very High
Injury 8 97.64 Very High Very High Very High
Toxicity 25 95.92 Very High Very High Very High
Necrosis 15 95.84 Very High Very High Very High
Increased Venous Pressure Under Development 6 95.04 Very High Very High Very High
Hepatotoxicity 39 94.88 High High
Hemorrhage 7 92.08 High High
Autoimmune Hepatitis 2 89.80 High High
Hepatitis 17 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A large increase of serum aspartate aminotransferase(AST), and liver weight and depletion of liver reduced glutathione (GSH) occurred in animals receiving toxic acetaminophen dose.
Positive_regulation (increase) of AST in liver associated with paracetamol
1) Confidence 0.67 Published 1995 Journal Arch. Toxicol. Section Abstract Doc Link 8773183 Disease Relevance 0.34 Pain Relevance 0.82
Whereas serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were markedly elevated after AAP administration (i.e. 9-20-fold), 2-AP pretreatment of animals before AAP administration resulted in >95% decreases in elevated serum aminotransferase activities. 2-AP was also effective against CCl4-induced hepatotoxicity.
Positive_regulation (elevated) of AST associated with paracetamol and hepatotoxicity
2) Confidence 0.67 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9065729 Disease Relevance 0.16 Pain Relevance 0.45
Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily).
Positive_regulation (increase) of AST associated with paracetamol
3) Confidence 0.67 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.44 Pain Relevance 0.60
Solanum alatum treatment (100 mg/kg, p.o.) decreased the elevation of serum alanine aminotransferase (ALT; GPT) and aspartate aminotransferase (AST; GOT) induced by acetaminophen (paracetamol) (600 mg/kg, i.p.) administration.
Positive_regulation (elevation) of AST associated with paracetamol
4) Confidence 0.67 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794122 Disease Relevance 0.26 Pain Relevance 0.47
Serum aspartate aminotransferase (AST) was elevated by 4 h.
Positive_regulation (elevated) of AST
5) Confidence 0.67 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12883092 Disease Relevance 0.27 Pain Relevance 0.83
Administration of L-carnitine significantly reduced AA-induced elevations in AST, ALT, TSA and MDA concentrations and increased GSH levels at all sampling points.
Positive_regulation (elevations) of AST associated with paracetamol
6) Confidence 0.67 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.73 Pain Relevance 1.07
Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily).
Positive_regulation (aspartate) of AST associated with paracetamol
7) Confidence 0.49 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.44 Pain Relevance 0.60
Pretreatment with total plant extract and swerchirin, the major component of the plant, significantly reduced the elevation of biochemical parameters, AST (aspartate aminotransferase), ALT (alanine aminotransferase) and ALP (alkaline phosphatase), the enzymes that are increased by liver damage (P < 0.001).
Positive_regulation (elevation) of AST in liver associated with hepatotoxicity
8) Confidence 0.47 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 16451758 Disease Relevance 0.26 Pain Relevance 0.26
WLP-S-10 200 mg/kg markedly reduced liver necrosis, serum ALT and AST elevation and GSH depletion after injection of acetaminophen.
Positive_regulation (elevation) of AST in liver
9) Confidence 0.45 Published 2008 Journal Liver Int. Section Body Doc Link 18435715 Disease Relevance 0.05 Pain Relevance 0
Administration of L-carnitine significantly reduced AA-induced elevations in AST, ALT, TSA and MDA concentrations and increased GSH levels at all sampling points.
Positive_regulation (increased) of AST associated with paracetamol
10) Confidence 0.45 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.74 Pain Relevance 1.14
AA increased serum AST, ALT, total sialic acid (TSA) and MDA as well as tissue TSA and MDA levels significantly with the highest increase observed at 4 h, but there was a decrease in blood and tissue GSH level.
Positive_regulation (increased) of AST in blood associated with paracetamol
11) Confidence 0.45 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.68 Pain Relevance 0.95
Solanum alatum treatment (100 mg/kg, p.o.) decreased the elevation of serum alanine aminotransferase (ALT; GPT) and aspartate aminotransferase (AST; GOT) induced by acetaminophen (paracetamol) (600 mg/kg, i.p.) administration.
Positive_regulation (induced) of AST associated with paracetamol
12) Confidence 0.45 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794122 Disease Relevance 0.26 Pain Relevance 0.47
In the MT-III null mice, ALT and AST activities were not elevated following the injection of Cd.
Neg (not) Positive_regulation (elevated) of AST
13) Confidence 0.43 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371971 Disease Relevance 0.47 Pain Relevance 0.14
The serum hepatic enzyme levels of AST and ALT increased after dosing morphine (100 mg/kg) at 02:00 and 14:00 h.
Positive_regulation (increased) of AST associated with morphine
14) Confidence 0.37 Published 2005 Journal Chronobiol. Int. Section Abstract Doc Link 16076651 Disease Relevance 0.22 Pain Relevance 0.88
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities elevated by injection of Cd were significantly higher in the MT-I/II null mice than in the wild-type mice.
Positive_regulation (elevated) of AST
15) Confidence 0.29 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371971 Disease Relevance 0.39 Pain Relevance 0.13
Clinical evidence demonstrates that fatty pancreas is associated with higher levels for visceral fat, AST, ALT, total cholesterol, triglyceride, insulin, and the HOMA-IR [40].
Positive_regulation (levels) of AST in fat associated with disorder of lipid metabolism
16) Confidence 0.19 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.38 Pain Relevance 0
Likewise, C57BL/6 mice fed a HFD showed elevated ALT, AST and ALK plasma concentrations indicating alteration of the hepatic and pancreatic function.
Positive_regulation (elevated) of AST in plasma
17) Confidence 0.19 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.33 Pain Relevance 0
Acetaminophen treatment significantly depleted glutathione content, increased oxidation stress and elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities (P < 0.05); however, the intake of SAC or SPC significantly alleviated glutathione depletion and the elevation of ALT and AST, enhanced glutathione peroxidase activity, and lowered malondialdehyde formation (P < 0.05).
Positive_regulation (increased) of AST associated with stress and paracetamol
18) Confidence 0.18 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.27 Pain Relevance 0.58
Acetaminophen treatment significantly depleted glutathione content, increased oxidation stress and elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities (P < 0.05); however, the intake of SAC or SPC significantly alleviated glutathione depletion and the elevation of ALT and AST, enhanced glutathione peroxidase activity, and lowered malondialdehyde formation (P < 0.05).
Positive_regulation (elevation) of AST associated with stress and paracetamol
19) Confidence 0.18 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.25 Pain Relevance 0.60
Elevated serum levels of AST and ALT were first observed 6–8 h after injection of 20 mg/kg of ConA and peaked at 12 h after injection (data not shown).
Positive_regulation (Elevated) of AST
20) Confidence 0.09 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.37 Pain Relevance 0

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