INT6406

Context Info Confidence 0.48 First Reported 1983 Last Reported 2010 Negated 10 Speculated 12 Reported most in Abstract Documents 280 Total Number 292 Disease Relevance 40.54 Pain Relevance 226.26

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)

Anatomy Link Frequency brain 11 ileum 5 neurons 5 pons 3 medulla 3 Oprm1 (Mus musculus) Oprm1 - K273A (1)

Pain Link Frequency Relevance Heat opioid receptor 8125 100.00 Morphine 4110 100.00 mu opioid receptor 2969 100.00 Opioid 2095 100.00 tolerance 721 100.00 agonist 449 100.00 antagonist 324 100.00 dopamine receptor 263 100.00 Enkephalin 219 100.00 Pain 192 100.00

Disease Link Frequency Relevance Heat Targeted Disruption 186 100.00 INFLAMMATION 69 99.92 Urological Neuroanatomy 238 99.82 Nicotine Addiction 196 99.76 Alcohol Addiction 67 99.76 Drug Dependence 129 99.68 Sprains And Strains 166 99.38 Neuroblastoma 33 99.28 Lordosis 21 99.24 Opiate Addiction 492 99.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, morphine administration did not alter the [(3)H]muscimol binding in mu-opioid receptor knockout mice.

mu-opioid receptor Binding (binding) of associated with targeted disruption, opioid receptor and morphine

1) Confidence 0.48 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 11927374 Disease Relevance 0.48 Pain Relevance 1.14

The mouse mu-opioid receptor gene, Oprm1, is recognized currently to contain 17 alternatively spliced exons that generate 24 splice variants encoding at least 11 morphine-binding isoforms of the receptor.

Oprm1 Binding (recognized) of associated with opioid receptor and morphine

2) Confidence 0.48 Published 2007 Journal Gene Section Abstract Doc Link 17156941 Disease Relevance 0.08 Pain Relevance 0.36

Interaction of mu-opioid receptor agonists and antagonists with the analgesic effect of buprenorphine in mice.

mu-opioid receptor Binding (Interaction) of associated with pain, analgesic, antagonist, agonist, opioid receptor and buprenorphine

3) Confidence 0.48 Published 2005 Journal Eur J Pain Section Title Doc Link 16139189 Disease Relevance 0 Pain Relevance 2.26

Instant coffee has been shown to displace binding of the mu opioid receptor antagonist, [3H]naloxone, but the putative active agent, feruloylquinide, has not been characterized.

mu opioid receptor Binding (binding) of associated with antagonist, narcan and mu opioid receptor

4) Confidence 0.48 Published 2004 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15088081 Disease Relevance 0.07 Pain Relevance 0.26

The fentanyl analogs caused a slight internalization of the mu receptor as accessed by antibody binding to the epitope-tagged mu receptor.

mu receptor Binding (binding) of

5) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.07 Pain Relevance 0.63

Mutagenesis studies revealed that morphine interacts differently with the mu receptor to activate it than do the fentanyl analogs which may explain its lack of desensitization of the mu receptor.

mu receptor Binding (interacts) of associated with morphine

6) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.05 Pain Relevance 0.58

Fentanyl and its analogs potently bound to the mu receptor and effectively inhibited cAMP accumulation.

mu receptor Binding (bound) of

7) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.08 Pain Relevance 0.57

Both additional competition studies and saturation studies indicate that the meptazinol-sensitive binding of the 3H-ligands corresponds to the high affinity, or mu-1, binding site.

mu-1 Binding (binding) of

8) Confidence 0.48 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6141283 Disease Relevance 0 Pain Relevance 1.24

To determine the general applicability of the (beta)arr2-muOR interaction in other neuronal systems, we have, in the present study, tested (beta)arr2 knock-out ((beta)arr2-KO) mice using the warm water tail-immersion paradigm, which primarily assesses spinal reflexes to painful thermal stimuli.

muOR Binding (interaction) of in spinal associated with targeted disruption and pain

9) Confidence 0.46 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451149 Disease Relevance 0.35 Pain Relevance 1.10

We have also determined endogenous PU.1 interactions with the 34-bp element of MOR promoter by chromatin immunoprecipitation assays.

MOR promoter Binding (interactions) of associated with opioid receptor

10) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0.20 Pain Relevance 0.64

In this preliminary study we examined in vivo mu opioid receptor (muOR) binding in three healthy opioid-dependent volunteers during maintenance on 2 and 16 mg sublingual buprenorphine (BUP) liquid, and after detoxification (0 mg) under double-blind, placebo-controlled conditions, and once in matched controls.

mu opioid receptor Spec (examined) Binding (binding) of in sublingual associated with mu opioid receptor, opioid and buprenorphine

11) Confidence 0.45 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10942856 Disease Relevance 0 Pain Relevance 0.77

In this preliminary study we examined in vivo mu opioid receptor (muOR) binding in three healthy opioid-dependent volunteers during maintenance on 2 and 16 mg sublingual buprenorphine (BUP) liquid, and after detoxification (0 mg) under double-blind, placebo-controlled conditions, and once in matched controls.

muOR Spec (examined) Binding (binding) of in sublingual associated with mu opioid receptor, opioid and buprenorphine

12) Confidence 0.45 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10942856 Disease Relevance 0 Pain Relevance 0.77

No effect of chronic nimodipine alone on mu-opioid receptor binding was observed.

mu-opioid receptor Binding (binding) of associated with opioid receptor

13) Confidence 0.45 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10880689 Disease Relevance 0 Pain Relevance 1.35

We conclude that dihydroetorphine is a selective ligand for the mu-opioid receptor.

mu-opioid receptor Binding (ligand) of associated with opioid receptor

14) Confidence 0.45 Published 1995 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8583370 Disease Relevance 0.08 Pain Relevance 0.52

No significant association of OPRM1 genetic variation to phenotype was observed.

OPRM1 Neg (No) Binding (association) of

15) Confidence 0.42 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.54 Pain Relevance 0.96

The mouse mu-opioid receptor gene, Oprm1, is recognized currently to contain 17 alternatively spliced exons that generate 24 splice variants encoding at least 11 morphine-binding isoforms of the receptor.

mu-opioid receptor gene Binding (recognized) of associated with opioid receptor and morphine

16) Confidence 0.42 Published 2007 Journal Gene Section Abstract Doc Link 17156941 Disease Relevance 0.08 Pain Relevance 0.36

Tramadol is an effective analgesic that works through a combined mechanism of weak mu receptor binding and the inhibition of serotonin and norepinephrine reuptake.

mu receptor Binding (binding) of associated with tramadol, analgesic and serotonin

17) Confidence 0.42 Published 1997 Journal Clin Ther Section Abstract Doc Link 9220207 Disease Relevance 0.48 Pain Relevance 1.30

None of the opioid analgesics used had any effect on pain behavior, and it was concluded that opioids with a high affinity for the mu receptor when injected intraarticularly were unlikely to be of use in the treatment or diagnosis of inflammatory arthritic pain in the strain of domestic fowl chosen.

mu receptor Binding (affinity) of associated with pain, inflammation, analgesic, sprains and strains, opioid and arthritis

18) Confidence 0.41 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10371665 Disease Relevance 0.79 Pain Relevance 1.31

It is emphasized that the aromatic structure of the C-terminal region of the peptide is not obligatory for the mu-receptor binding.

mu-receptor Binding (binding) of

19) Confidence 0.40 Published 1986 Journal Bioorg. Khim. Section Abstract Doc Link 3021174 Disease Relevance 0 Pain Relevance 1.50

Taken together, these results indicate that methadone and buprenorphine interact differently with the mouse mu receptor than either morphine or DAMGO.

mu receptor Binding (interact) of associated with methadone, morphine and buprenorphine

20) Confidence 0.38 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 8995364 Disease Relevance 0.06 Pain Relevance 1.97

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