INT64062

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.30
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 14 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
Morphine 10 99.70 Very High Very High Very High
antagonist 2 98.64 Very High Very High Very High
narcan 5 98.22 Very High Very High Very High
Opioid 4 95.76 Very High Very High Very High
alcohol 1 92.04 High High
dopamine receptor 2 81.72 Quite High
Hippocampus 1 67.44 Quite High
amygdala 1 66.92 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 77.40 Quite High
Neuroblastoma 4 75.00 Quite High
Alcohol Addiction 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced up-regulation of MOR was blocked by interleukin-1 receptor type 1 antagonist.
Negative_regulation (blocked) of Regulation (regulation) of MOR associated with antagonist and mu opioid receptor
1) Confidence 0.41 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20615556 Disease Relevance 0.07 Pain Relevance 0.97
Morphine-mediated down-regulation of MOR was blocked by naltrexone and IL-1?
Negative_regulation (blocked) of Regulation (regulation) of MOR associated with mu opioid receptor and morphine
2) Confidence 0.41 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20615556 Disease Relevance 0.07 Pain Relevance 0.96
However, the decreased [3H]naloxone binding observed in subjects with the A1 allele may be a compensatory response to their decreased dopaminergic modulation of opiate receptor activity.
Negative_regulation (decreased) of Regulation (modulation) of opiate receptor associated with narcan and opiate
3) Confidence 0.31 Published 1996 Journal Brain Res. Section Abstract Doc Link 8773786 Disease Relevance 0.15 Pain Relevance 0.55

General Comments

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