INT64065

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 14
Disease Relevance 12.62
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Btg3)
Anatomy Link Frequency
blood 1
connective tissue 1
Btg3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 121 99.96 Very High Very High Very High
Inflammation 78 97.68 Very High Very High Very High
analgesia 1 97.08 Very High Very High Very High
Arthritis 200 96.76 Very High Very High Very High
Fibrositis 70 90.24 High High
depression 1 73.60 Quite High
Osteoarthritis 10 70.72 Quite High
Inflammatory response 1 63.52 Quite High
Cannabinoid receptor 2 63.40 Quite High
Cannabinoid 3 54.36 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 52 100.00 Very High Very High Very High
Rheumatoid Arthritis 121 99.96 Very High Very High Very High
Rheumatic Diseases 190 99.92 Very High Very High Very High
Systemic Sclerosis 150 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 327 99.26 Very High Very High Very High
Dermatomyositis 50 98.80 Very High Very High Very High
Catalepsy 2 98.16 Very High Very High Very High
Uveitis 110 97.76 Very High Very High Very High
Hypothermia 2 97.72 Very High Very High Very High
Disease 304 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Environmental toxins may also predispose to ANA production.
Gene_expression (production) of ANA
1) Confidence 0.65 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.13 Pain Relevance 0.03
Positive antibodies to double-stranded DNA or to extractable nuclear antigens (Sm, RNP) indicating SLE or MCTD were strongly correlated with an ANA titer ?
Gene_expression (titer) of ANA associated with systemic sclerosis and systemic lupus erythematosus
2) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.00 Pain Relevance 0.15
We would conclude from these findings that only rarely is the presence of ANA the harbinger of occult SLE or another connective tissue disease.


Gene_expression (presence) of ANA in connective tissue associated with disease and systemic lupus erythematosus
3) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.41 Pain Relevance 0.23
In other words, it would be best if the ANA test had not been done in the first place!
Gene_expression (test) of ANA
4) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.99 Pain Relevance 0.13
This combination was also found in 12.5% of ANA positive JRA and 5.4% of ANA positive JDM patients.
Gene_expression (positive) of ANA associated with rheumatoid arthritis and dermatomyositis
5) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.85 Pain Relevance 0.05
It is not clear why there is such a low frequency of ANA positivity in children, compared to the much higher frequency found in most adult studies (of which only two of many are referenced here).
Gene_expression (positivity) of ANA
6) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.42 Pain Relevance 0.08
Five children developed SLE, compared to none of those who were ANA negative (p < 0.001). [26]

ANA positivity as a risk factor for uveitis in children with JIA

Neg (negative) Gene_expression (negative) of ANA associated with uveitis, systemic lupus erythematosus and arthritis
7) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.25 Pain Relevance 0.09
Development of rheumatic diseases in ANA positive individuals
Gene_expression (positive) of ANA associated with rheumatic diseases
8) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.32 Pain Relevance 0.17
Referrals for positive ANA titers
Gene_expression (titers) of ANA
9) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.90 Pain Relevance 0.11
So what should be done with a positive ANA test?
Gene_expression (test) of ANA
10) Confidence 0.56 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.90 Pain Relevance 0.08
Thus, the offspring from ANA-treated dams showed impaired responsiveness to a challenge with ANA or delta 0-THC expressed as a lack of immobility in the ring test for catalepsy, hypothermia and analgesia.
Neg (lack) Gene_expression (expressed) of ANA associated with hypothermia, catalepsy and analgesia
11) Confidence 0.53 Published 1996 Journal Psychoneuroendocrinology Section Abstract Doc Link 8774060 Disease Relevance 0.59 Pain Relevance 0.25
We also measured the serum levels of two autoimmunity-related antibodies, namely, anti-nuclear antibody (ANA) and anti-dsDNA antibody.
Gene_expression (levels) of ANA associated with autoimmune disease
12) Confidence 0.19 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.79 Pain Relevance 0.03
Our previous study showed a remarkable increase in the levels of autoantibodies including anti-double strand DNA (dsDNA) IgG and IgM antibodies, and anti-nuclear antibody (ANA) in the peripheral blood [17].
Gene_expression (antibodies) of ANA in blood
13) Confidence 0.12 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 1.06 Pain Relevance 0
The CBC, ALT, AST, BUN, creatinine and ANA levels were measured again in 8 weeks.
Gene_expression (levels) of ANA
14) Confidence 0.09 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2958860 Disease Relevance 0 Pain Relevance 0

General Comments

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