INT64076

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Context Info
Confidence 0.40
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 47
Total Number 49
Disease Relevance 11.52
Pain Relevance 24.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
neurons 4
ciliary 2
neuronal 2
sensory neurons 1
aorta 1
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 15 100.00 Very High Very High Very High
Calcium channel 12 100.00 Very High Very High Very High
qutenza 604 99.98 Very High Very High Very High
nociceptor 198 99.88 Very High Very High Very High
IPN 19 99.82 Very High Very High Very High
Morphine 184 99.68 Very High Very High Very High
Pain 370 99.52 Very High Very High Very High
Snapping jaw 192 99.46 Very High Very High Very High
Antinociceptive 4 99.44 Very High Very High Very High
agonist 213 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 10 99.84 Very High Very High Very High
Inflammatory Pain 27 99.82 Very High Very High Very High
Nociception 104 99.54 Very High Very High Very High
Temporomandibular Joint Syndrome 192 99.46 Very High Very High Very High
Urological Neuroanatomy 4 99.28 Very High Very High Very High
Neuropathic Pain 80 99.20 Very High Very High Very High
Stroke 52 99.04 Very High Very High Very High
Cv Unclassified Under Development 119 98.48 Very High Very High Very High
Drug Induced Neurotoxicity 11 96.60 Very High Very High Very High
Pain 359 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The channel activation and steady-state inactivation occurred at very negative potentials with the threshold for activation at -55 mV and half-maximal inactivation at -78.7 mV.
Positive_regulation (activation) of channel
1) Confidence 0.40 Published 2001 Journal Pflugers Arch. Section Abstract Doc Link 11692262 Disease Relevance 0 Pain Relevance 0.17
CONCLUSION: Our data show that the hypotensive effect induced by TRPV4 activation attributes to, at least in part, activation of MaxiK channels and CGRP receptors upon CGRP release from sensory nerves.


Positive_regulation (activation) of MaxiK in sensory nerves
2) Confidence 0.38 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
These results indicate that the activation of KCa channels involved, at least in part, the GS-induced vasorelaxation of rat aorta.
Positive_regulation (activation) of KCa in aorta
3) Confidence 0.37 Published 2001 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11152372 Disease Relevance 0 Pain Relevance 0
In cultured VSMC and endothelial cells, KCa channels were activated by GS.
Positive_regulation (activated) of KCa in VSMC
4) Confidence 0.37 Published 2001 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11152372 Disease Relevance 0 Pain Relevance 0
Thus, voltage-activated Na(+) channel blockers can attenuate nociceptive behaviour in the formalin test, and a specific mechanism of action on Na(+) channel function may be required for this to occur.
Positive_regulation (voltage-activated) of channel associated with nociception
5) Confidence 0.34 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12079688 Disease Relevance 0.52 Pain Relevance 0.16
We have used the rat formalin test to compare the anti-nociceptive properties of several voltage-activated Na(+) channel blockers.
Positive_regulation (voltage-activated) of channel associated with nociception
6) Confidence 0.34 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12079688 Disease Relevance 0.23 Pain Relevance 0.16
BK-alpha mRNA increased threefold, and BK-alpha protein increased fivefold from 3 days to 6 wk.
Positive_regulation (increased) of BK-alpha
7) Confidence 0.28 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17234952 Disease Relevance 0 Pain Relevance 0.27
In cultured VSMC and endothelial cells, KCa channels were activated by GS.
Positive_regulation (activated) of KCa in endothelial cells
8) Confidence 0.13 Published 2001 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11152372 Disease Relevance 0 Pain Relevance 0
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

Background

Positive_regulation (activated) of channel in microglia associated with drug induced neurotoxicity
9) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Title Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0
Here, our observation that apamin-sensitive SK channels are not required for bacterial phagocytosis might reflect a lack of channel activation because phagocytosis can be Ca2+ independent [64].
Positive_regulation (activation) of channel
10) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.47 Pain Relevance 0.08
The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca(2+)-permeable nonspecific cation channel activated by various painful stimuli including ischemia.
Positive_regulation (activated) of channel associated with pain and ischemia
11) Confidence 0.05 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18256211 Disease Relevance 0.10 Pain Relevance 0.29
The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca(2+)-permeable nonspecific cation channel activated by various painful stimuli including ischemia.
Positive_regulation (activated) of channel associated with pain and ischemia
12) Confidence 0.05 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18256211 Disease Relevance 0.10 Pain Relevance 0.29
The GABA release from the boutons was action potential dependent since eIPSCs were blocked in the presence of either voltage-dependent Na(+) or Ca(2+)channel blocker.
Positive_regulation (voltage-dependent) of channel in boutons associated with action potential and gaba
13) Confidence 0.03 Published 2002 Journal Neurosci. Res. Section Abstract Doc Link 11900828 Disease Relevance 0 Pain Relevance 0.36
In conclusion, this study shows a peripheral antinociceptive effect of pertussis toxin, resulting from the activation of the arginine/NO/cGMP/PKG/ATP-sensitive K(+) channel pathway.
Positive_regulation (activation) of channel associated with bordatella infection and antinociceptive
14) Confidence 0.03 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930443 Disease Relevance 0.23 Pain Relevance 0.20
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Positive_regulation (activation) of channel associated with bordatella infection, analgesic and antinociceptive
15) Confidence 0.03 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 16930443 Disease Relevance 0.29 Pain Relevance 0.36
Upon binding to its receptor, capsaicin opens a cation channel leading to Ca2+ influx.
Positive_regulation (leading) of channel associated with qutenza
16) Confidence 0.02 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8901026 Disease Relevance 0 Pain Relevance 0.42
It appears that CompB, at nanomolar concentrations, is a pure, selective and competitive antagonist of postsynaptic NOP receptors that mediate inwardly rectifying K(+) channel activation in ventrolateral PAG neurons.
Positive_regulation (activation) of channel in neurons associated with antagonist and central grey
17) Confidence 0.02 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12069909 Disease Relevance 0.35 Pain Relevance 0.75
L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells.
Positive_regulation (activation) of channel in pituitary associated with nav1.3, calcium channel, nav1.2 and sodium channel
18) Confidence 0.02 Published 2003 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12941467 Disease Relevance 0 Pain Relevance 0.75
Thus, GH3 cells express multiple Na+ channel subunits and L-type Ca2+ channel activity up-regulates in a specific way the mRNAs for Nav1.2 and Nav1.3.
Positive_regulation (up-regulates) of channel in GH3 associated with nav1.3 and nav1.2
19) Confidence 0.02 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941467 Disease Relevance 0 Pain Relevance 1.08
However, the means by which morphine regulates mKCa channel activation to induce preconditioning is unknown.
Positive_regulation (activation) of channel associated with morphine
20) Confidence 0.02 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.05 Pain Relevance 0.49

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