INT64081

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.07
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Stx1a) vesicle-mediated transport (Stx1a) plasma membrane (Stx1a)
protein binding, bridging (Stx1a) protein complex (Stx1a)
Anatomy Link Frequency
lateral 1
neurite 1
Stx1a (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 1 93.44 High High
medulla 2 76.24 Quite High
Pyramidal cell 9 61.52 Quite High
Hippocampus 18 57.12 Quite High
Neurotransmitter 44 50.00 Quite Low
local anesthetic 1 49.56 Quite Low
Glutamate 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5 69.44 Quite High
Schizophrenia 21 50.00 Quite Low
Congenital Anomalies 6 9.12 Low Low
Ganglion Cysts 16 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 4 5.00 Very Low Very Low Very Low
Psychosis 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution of syntaxin-1 was not affected by tomosyn deficiency.
Neg (not) Regulation (affected) of syntaxin-1
1) Confidence 0.25 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.06
In addition, Rho-associated serine/threonine kinase activated by Rho small G protein phosphorylates syntaxin-1, thereby increasing the affinity of syntaxin-1 for tomosyn and the formation of a stable complex between the two, resulting in inhibition of the formation of the SNARE complex during neurite extension (Sakisaka et al., 2004).
Regulation (affinity) of syntaxin-1 in neurite
2) Confidence 0.18 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.07 Pain Relevance 0
In our experiments, we did not find any changes in the steady-state levels of these exocytotic regulators, including SNARE proteins (SNAP25, syntaxin-1, and VAMP2), synaptotagamin-1, VGLUT1, munc18-1, dynamin-1, and complexin1/2 (Fig. 7).
Neg (not) Regulation (changes) of syntaxin-1
3) Confidence 0.05 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
Neither saline control infusions into the MS nor procaine infusions into the lateral septum and paraventricular thalamic nucleus affected HPC-theta or running behavior.
Regulation (affected) of HPC-theta in lateral
4) Confidence 0.03 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8774461 Disease Relevance 0 Pain Relevance 0.08

General Comments

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