INT64096

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.20
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
Anatomy Link Frequency
thyroid 1
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 99.98 Very High Very High Very High
c fibre 1 74.56 Quite High
agonist 2 64.44 Quite High
beta blocker 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 7 97.56 Very High Very High Very High
Asthma 22 85.68 High High
Mycobacterial Infection 81 74.88 Quite High
Chronic Sinusitis 1 60.08 Quite High
Infection 11 55.92 Quite High
Toxicity 1 50.32 Quite High
Hyperplasia 10 42.56 Quite Low
Stroke 3 41.84 Quite Low
Pathologic Constriction 2 38.48 Quite Low
Acid Reflux 1 37.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus clonidine reduced both AHR and HVD but the absolute level of ventilation at the end of hypoxia was unchanged.
Negative_regulation (reduced) of AHR associated with hypoxia and clonidine
1) Confidence 0.37 Published 1996 Journal Br J Anaesth Section Abstract Doc Link 8777100 Disease Relevance 0.55 Pain Relevance 0.51
In a latter study they showed that functional antagonism of MBP with the systemically administered polyanion heparin reversed this AHR [17].
Negative_regulation (reversed) of AHR
2) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.29 Pain Relevance 0.07
The differential effects of dioxins on thyroid hormone homeostasis that appear to be related to exposure levels could potentially be attributed to down-regulation of the AhR after large exposures, such as noted after the Seveso (Italy) accident (Landi et al. 2003).
Negative_regulation (regulation) of AhR in thyroid
3) Confidence 0.15 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1940071 Disease Relevance 0 Pain Relevance 0
Other recent examples of nonobvious embryonic defects that cause remarkable cardiac dysfunction at later stages of development include the disruption of genes encoding the aryl hydrocarbon receptor (Thackaberry et al. 2002) and retinol binding protein (Smith SM, Flentke GR, Lough J, unpublished data; Wendler et al. 2003).
Negative_regulation (disruption) of aryl hydrocarbon receptor
4) Confidence 0.06 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1480523 Disease Relevance 0.05 Pain Relevance 0
Inversely, and based on our luciferase reporter gene assays, the loss of the potential PAX5, AHR and ARNT transcription factor binding sites predicted for the IRGM variant ?
Negative_regulation (loss) of AHR
5) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.31 Pain Relevance 0

General Comments

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