INT64110

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 10
Speculated 3
Reported most in Body
Documents 68
Total Number 71
Disease Relevance 58.11
Pain Relevance 51.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
spinal cord 22
sciatic nerve 20
neuronal 14
brain 8
muscles 8
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1198 100.00 Very High Very High Very High
Morphine 337 100.00 Very High Very High Very High
cocaine 90 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 40 100.00 Very High Very High Very High
nMDA receptor 7 100.00 Very High Very High Very High
Neuropathic pain 579 99.98 Very High Very High Very High
Peripheral nerve injury 75 99.98 Very High Very High Very High
tetrodotoxin 3 99.98 Very High Very High Very High
opioid receptor 261 99.92 Very High Very High Very High
Sciatic nerve 1413 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2186 100.00 Very High Very High Very High
Nervous System Injury 1237 99.98 Very High Very High Very High
Neuropathic Pain 1228 99.98 Very High Very High Very High
Amyloid Plaque 24 99.90 Very High Very High Very High
Peritonitis 192 99.80 Very High Very High Very High
Congenital Anomalies 42 99.72 Very High Very High Very High
Ganglion Cysts 408 99.68 Very High Very High Very High
Stress 69 99.42 Very High Very High Very High
INFLAMMATION 327 99.24 Very High Very High Very High
Injury 143 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of Gene_expression (expression) of nNOS associated with hippocampus, cocaine and morphine
1) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.70
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of Gene_expression (expression) of nNOS associated with hippocampus, cocaine and morphine
2) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.72
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of Gene_expression (expression) of nNOS associated with hippocampus, cocaine and morphine
3) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.71
Consistent with these findings in rats, our study showed that unilateral injury of the fifth spinal nerve in mice also increased expression of nNOS protein in the ipsilateral fifth DRG, but not in dorsal horn.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of nNOS protein in dorsal horn associated with dorsal root ganglion, injury and dorsal horn
4) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.20 Pain Relevance 0.91
These data suggest that the increased spinal cord expression of NOS1, regulated by NOS2, might be responsible for the maintenance of chronic peripheral neuropathic pain in mice and propose these enzymes as interesting therapeutic targets for their treatment.



Positive_regulation (increased) of Gene_expression (expression) of NOS1 in spinal cord associated with neuropathic pain and spinal cord
5) Confidence 0.66 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.54 Pain Relevance 0.98
In addition, our data also indicate that the presence of NOS2 is required for the increased expression of NOS1 in the spinal cord whereas an enhanced expression of NOS1 might avoid an up-regulation of NOS2 in the spinal cord of sciatic nerve-injured mice.
Positive_regulation (enhanced) of Gene_expression (expression) of NOS1 in sciatic nerve associated with sciatic nerve and spinal cord
6) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.35 Pain Relevance 0.97
The present study demonstrates for first time the participation of NOS1 and NOS2 in the development and maintenance of thermal hyperalgesia and thermal allodynia induced by the chronic constriction of sciatic nerve and suggests that the increased spinal cord expression of NOS1 is regulated by NOS2, and might be responsible for the maintenance of chronic peripheral neuropathic pain in mice.
Positive_regulation (increased) of Gene_expression (expression) of NOS1 in spinal cord associated with allodynia, thermal hyperalgesia, neuropathic pain, sciatic nerve and spinal cord
7) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.39 Pain Relevance 0.86
In addition, our data also indicate that the presence of NOS2 is required for the increased expression of NOS1 in the spinal cord whereas an enhanced expression of NOS1 might avoid an up-regulation of NOS2 in the spinal cord of sciatic nerve-injured mice.
Positive_regulation (increased) of Gene_expression (expression) of NOS1 in sciatic nerve associated with sciatic nerve and spinal cord
8) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.37 Pain Relevance 0.95
Our data showed that peripheral neuropathic pain increases the transcription and expression of NOS1 in the spinal cord of WT mice, indicating that NOS1 might be the main responsible for the maintenance of peripheral neuropathic pain after the total sciatic nerve ligation.
Positive_regulation (increases) of Gene_expression (expression) of NOS1 in sciatic nerve associated with neuropathic pain, sciatic nerve and spinal cord
9) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.17 Pain Relevance 1.04
Moreover, the presence of NOS2 is required to increase the spinal cord expression of NOS1 whereas an increased NOS1 expression might avoid the up-regulation of NOS2 in the spinal cord of nerve injured WT mice.


Positive_regulation (increase) of Gene_expression (expression) of NOS1 in nerve associated with spinal cord
10) Confidence 0.66 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.66 Pain Relevance 1.02
Our data also indicate that: i) the increased spinal cord expression of NOS1 plays a critical role in the maintenance of peripheral neuropathic pain, ii) a compensatory up-regulation of NOS2 isoform takes place in the spinal cord of sciatic nerve-injured NOS1-KO mice, and iii) the up-regulation of NOS1 in the spinal cord of sciatic nerve-injured WT mice at 21 days after surgery is modulated by NOS2.


Positive_regulation (increased) of Gene_expression (expression) of NOS1 in spinal cord associated with targeted disruption, neuropathic pain, sciatic nerve and spinal cord
11) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.02 Pain Relevance 0.93
Moreover, the presence of NOS2 is required to increase the spinal cord expression of NOS1 whereas an increased NOS1 expression might avoid the up-regulation of NOS2 in the spinal cord of nerve injured WT mice.


Positive_regulation (increased) of Gene_expression (expression) of NOS1 in nerve associated with spinal cord
12) Confidence 0.66 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.62 Pain Relevance 1.00
Moreover, the MOR(-/-) mice also showed significantly higher morphine- or cocaine-induced nNOS expression levels in the DG than in the saline treated MOR(+/+) mice (morphine, +234%; cocaine, +54%).
Positive_regulation (induced) of Gene_expression (expression) of nNOS associated with hippocampus, cocaine and morphine
13) Confidence 0.61 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.09 Pain Relevance 1.69
It has been reported that constriction of the common sciatic nerve in rats increased nNOS expression in the ipsilateral L4-L6 DRG, but not in spinal segments L4-L6 [20].
Positive_regulation (increased) of Gene_expression (expression) of nNOS in sciatic nerve associated with dorsal root ganglion and sciatic nerve
14) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.30 Pain Relevance 0.80
Peripheral nerve injury increased expression of both mRNA and protein for nNOS in the DRG, but not in spinal cord [19-22].
Positive_regulation (increased) of Gene_expression (expression) of nNOS in Peripheral nerve associated with dorsal root ganglion, nervous system injury, spinal cord and peripheral nerve injury
15) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.83 Pain Relevance 1.31
In accordance to our results, an increase in the spinal cord expression of NOS1 at 14 days after nerve injury have been also demonstrated although the expression of this isoenzyme on day 7th after injury remains unaltered [5], [7]–[8].
Positive_regulation (increase) of Gene_expression (expression) of NOS1 in spinal cord associated with nervous system injury, injury and spinal cord
16) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.10 Pain Relevance 0.90
Indeed, the 6-day model of catheter-induced peritonitis does not induce nNOS expression [12] whereas LPS treatment induces nNOS expression in muscles [45].
Positive_regulation (induces) of Gene_expression (expression) of nNOS in muscles associated with peritonitis
17) Confidence 0.57 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.58 Pain Relevance 0.03
Densitometry analysis confirmed that LPS treatment induced an 11-fold increase in nNOS expression (relative optical density: 1170 ± 200%, P = 0.005), and 2-fold increase in eNOS expression (relative optical density: 247 ± 110%, P = 0.01) in the peritoneum (Figure 4B).


Positive_regulation (increase) of Gene_expression (expression) of nNOS in peritoneum
18) Confidence 0.57 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.46 Pain Relevance 0.03
Thus, although nNOS expression is increased in the acute phase of myocardial infarction in both infarcted and non-infarcted tissues in the rat heart [9], it has been reported that in the nNOS knockout mice, there is no change in myocardial infarct size [10,11].
Positive_regulation (increased) of Gene_expression (expression) of nNOS in heart associated with targeted disruption and myocardial infarction
19) Confidence 0.57 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.53 Pain Relevance 0.11
We have extended these findings and have shown for the first time that CFA injection also increased the nNOS and eNOS gene expression.
Positive_regulation (increased) of Gene_expression (expression) of nNOS
20) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.79 Pain Relevance 1.02

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