INT64111

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 8.96
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
hippocampus 4
neuronal 3
spinal cord 2
blood 2
neurons 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 60 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 11 100.00 Very High Very High Very High
vincristine 10 100.00 Very High Very High Very High
Inflammation 10 99.64 Very High Very High Very High
IPN 5 99.56 Very High Very High Very High
Hippocampus 52 99.52 Very High Very High Very High
Stimulus evoked pain 7 99.04 Very High Very High Very High
fibrosis 47 98.96 Very High Very High Very High
nMDA receptor 2 98.64 Very High Very High Very High
imagery 33 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 172 100.00 Very High Very High Very High
INFLAMMATION 10 99.64 Very High Very High Very High
Inflammatory Pain 5 99.56 Very High Very High Very High
Muscular Dystrophy 242 99.30 Very High Very High Very High
Aggression 5 99.24 Very High Very High Very High
Pain 22 99.04 Very High Very High Very High
Fibrosis 56 98.96 Very High Very High Very High
Hypersensitivity 11 98.84 Very High Very High Very High
Stress 42 98.66 Very High Very High Very High
Congenital Anomalies 29 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry demonstrated a consistent reduction of nNOS and NK2 receptor expression in mdx stomach smooth muscle cells and no change in nNOS and NK1 receptor expression in neurones.
Negative_regulation (reduction) of Gene_expression (expression) of nNOS in stomach smooth muscle
1) Confidence 0.57 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.32
Conversely, there were no changes in nNOS distribution and expression in normal regenerated fibers, suggesting that the decrease in nNOS expression reported for mdx mice might be attributed to the absence of dystrophin.
Negative_regulation (decrease) of Gene_expression (expression) of nNOS
2) Confidence 0.50 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11353428 Disease Relevance 0 Pain Relevance 0.14
However, the expression of myogenic nNOS was markedly reduced in mdx mice.
Negative_regulation (reduced) of Gene_expression (expression) of nNOS
3) Confidence 0.48 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11668035 Disease Relevance 0 Pain Relevance 0.09
Deletion of the nNOS gene not only eliminates nNOS protein, but in common with many gene deletions, affects several 'down-stream' processes.
Negative_regulation (eliminates) of Gene_expression (Deletion) of nNOS gene
4) Confidence 0.43 Published 2005 Journal Novartis Found. Symp. Section Abstract Doc Link 16206879 Disease Relevance 0.38 Pain Relevance 0.10
Targeted disruption of the nNOS gene significantly reduced CFA-induced mechanical pain hypersensitivity during the maintenance (but not the development) of inflammatory pain, while it failed to attenuate either development or maintenance of CFA-induced thermal pain hypersensitivity.
Negative_regulation (reduced) of Gene_expression (disruption) of nNOS gene associated with targeted disruption, ipn, hypersensitivity and stimulus evoked pain
5) Confidence 0.43 Published 2005 Journal Pain Section Abstract Doc Link 16297560 Disease Relevance 1.29 Pain Relevance 0.90
In contrast, neuronal NO synthase (nNos) expression was reduced in both soleus and white vastus lateralis muscles (Fig. 2D), whereas endothelial NO synthase (eNos) expression was low in white vastus lateralis muscles under basal conditions and was induced to a level comparable to that in the soleus muscles (Fig. 2E) following LPS injection.
Negative_regulation (reduced) of in soleus Gene_expression (expression) of neuronal NO synthase in neuronal
6) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.30 Pain Relevance 0
Sciatic nerve ligature decreased paw withdrawal latency to thermal stimulus only in WT mice and this response was abolished in mice lacking NOS1 or NOS2 genes (Fig. 1B).
Negative_regulation (lacking) of Neg (lacking) Gene_expression (genes) of NOS1 in paw associated with sciatic nerve and withdrawal
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.11 Pain Relevance 0.52
We found that the levels of nNOS mRNA decreased in the cortex and the hippocampus of 8- vs 2-month-old animals followed by an increase in 12-vs 8-month-old animals in both strains.
Negative_regulation (decreased) of Gene_expression (levels) of nNOS mRNA in hippocampus associated with hippocampus and sprains and strains
8) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1766358 Disease Relevance 0.38 Pain Relevance 0.27
M), or the selective nNOS inhibitor TRIM (100 ?
Negative_regulation (inhibitor) of Gene_expression (selective) of nNOS
9) Confidence 0.35 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.47 Pain Relevance 0.09
M), or the selective nNOS inhibitor TRIM (100 ?
Negative_regulation (inhibitor) of Gene_expression (selective) of nNOS
10) Confidence 0.35 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.45 Pain Relevance 0.12
Our present results extend the observation that nNOS may be involved in the oxidative stress observed in the brain of SAMP8 and highlight the possibility that reduced NO/nNOS synthesis within the hippocampus at an early age may be a marker of vulnerability.
Neg (NO) Negative_regulation (reduced) of Neg (NO) Gene_expression (synthesis) of nNOS in hippocampus associated with stress and hippocampus
11) Confidence 0.32 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.70 Pain Relevance 0.14
The contents of NO metabolites, cGMP and protein levels of neuronal NOS in the spinal cord in vincristine-treated mice were significantly reduced compared to those in vehicle-treated naive mice.
Negative_regulation (reduced) of Gene_expression (levels) of neuronal NOS in spinal cord associated with vincristine and spinal cord
12) Confidence 0.28 Published 2005 Journal Pain Section Abstract Doc Link 16098672 Disease Relevance 0.25 Pain Relevance 0.87
Upon inhibition of these early processes (e.g., Akt or nNOS), the subsequent steps responsible for NMDAR sustained potentiation and MOR tolerance do not occur.
Negative_regulation (inhibition) of Gene_expression (e.g.) of nNOS associated with tolerance and opioid receptor
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.05 Pain Relevance 1.10
Conversely, direct depolarization of cultured neurons with K+ completely downregulated nNOS expression.
Negative_regulation (downregulated) of Gene_expression (expression) of nNOS in neurons
14) Confidence 0.26 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8778295 Disease Relevance 0 Pain Relevance 0.23
Imaging of nitrergic neurotransmission may help distinguish between disorders due to impaired NO production such as nNOS deficiency and those due to impaired NO action such as seen in deficiencies of NO sensitive guanylyl cyclase [4], cGMP kinase1 [5], Collagen XIXa1 [6] or c-kit [24].
Negative_regulation (impaired) of Gene_expression (deficiency) of nNOS associated with imagery
15) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.32 Pain Relevance 0.36
When the expression of nNOS is restored then it has been reported that the inflammation, fibrosis and ECG abnormalities are prevented in the mdx mouse [52].
Negative_regulation (restored) of Gene_expression (expression) of nNOS associated with fibrosis, inflammation and congenital anomalies
16) Confidence 0.24 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.98 Pain Relevance 0.15
Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression.
Negative_regulation (lacking) of Gene_expression (expression) of type I NOS gene in blood
17) Confidence 0.22 Published 1996 Journal Am. J. Physiol. Section Title Doc Link 8780207 Disease Relevance 0.09 Pain Relevance 0.09
-subunit of AChRs, which promotes their binding to rapsyn and association with other AChRs [51].Can muscular degeneration in DMD patients be explained solely by a reduction in nNOS levels?
Negative_regulation (reduction) of Gene_expression (levels) of nNOS associated with muscular dystrophy
18) Confidence 0.14 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.20 Pain Relevance 0.16
Several studies focussing on individual proteins have shown that the presence of Nrf2 is essential for the enhanced expression of several antioxidant response proteins following administration of certain chemical inducers, however, constitutive expression of the same genes is often unaffected or only marginally reduced by deletion of the Nrf2 gene [9,11,14,23–29].
Negative_regulation (reduced) of Gene_expression (expression) of constitutive
19) Confidence 0.10 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0.52 Pain Relevance 0.11
Several studies focussing on individual proteins have shown that the presence of Nrf2 is essential for the enhanced expression of several antioxidant response proteins following administration of certain chemical inducers, however, constitutive expression of the same genes is often unaffected or only marginally reduced by deletion of the Nrf2 gene [9,11,14,23–29].
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of constitutive
20) Confidence 0.10 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0.52 Pain Relevance 0.11

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