INT64112

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 9
Speculated 10
Reported most in Body
Documents 22
Total Number 34
Disease Relevance 21.45
Pain Relevance 14.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
spinal cord 10
sciatic nerve 8
brain 7
dorsal horn 4
hippocampus 3
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 507 100.00 Very High Very High Very High
Morphine 158 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 22 100.00 Very High Very High Very High
Peripheral nerve injury 48 99.92 Very High Very High Very High
Sciatic nerve 557 99.84 Very High Very High Very High
antagonist 18 99.70 Very High Very High Very High
dorsal root ganglion 270 99.68 Very High Very High Very High
Opioid 29 99.48 Very High Very High Very High
Dorsal horn 76 99.36 Very High Very High Very High
qutenza 4 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 865 100.00 Very High Very High Very High
Nervous System Injury 662 100.00 Very High Very High Very High
Ganglion Cysts 270 99.68 Very High Very High Very High
Aggression 5 99.24 Very High Very High Very High
Neuropathic Pain 538 99.12 Very High Very High Very High
Aging 50 98.92 Very High Very High Very High
Stress 25 98.64 Very High Very High Very High
Inflammatory Pain 55 97.32 Very High Very High Very High
Drug Dependence 4 96.56 Very High Very High Very High
Drug Induced Neurotoxicity 8 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The present study was undertaken to determine the effect of chronic morphine treatment and abstinence on the expression of neuronal NO synthase (neuronal NOS, nNOS) in several brain regions of mice.
Spec (determine) Regulation (effect) of Gene_expression (expression) of neuronal NO synthase in brain
1) Confidence 0.62 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10663419 Disease Relevance 0.10 Pain Relevance 0
Finally, we examined whether peripheral spinal nerve injury altered the expression of nNOS, iNOS, or eNOS in the DRG and spinal cord of WT mice.
Spec (whether) Regulation (altered) of Gene_expression (expression) of nNOS in spinal nerve associated with dorsal root ganglion, nervous system injury and spinal cord
2) Confidence 0.60 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.26 Pain Relevance 0.56
Therefore, we hypothesized that the unaltered changes in NOS1 expression observed in NOS2-KO mice and the genetic lack of NOS2 in these KO mice might explain the absence of mechanical and thermal allodynia as well as thermal hyperalgesia in their behavior responses after sciatic nerve ligation.
Spec (might) Regulation (unaltered) of Gene_expression (expression) of NOS1 in sciatic nerve associated with targeted disruption, allodynia, thermal hyperalgesia and sciatic nerve
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.48 Pain Relevance 0.93
In addition, no compensatory changes in the spinal cord expression of NOS1 gene in sham-operated NOS2-KO mice have been also established.
Neg (no) Regulation (changes) of Gene_expression (expression) of NOS1 gene in spinal cord associated with targeted disruption and spinal cord
4) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.28 Pain Relevance 0.87
Our results demonstrate that in contrast to WT mice, the spinal cord expression of NOS1 in NOS2-KO animals was not altered by sciatic nerve injury.
Neg (not) Regulation (altered) of Gene_expression (expression) of NOS1 in sciatic nerve associated with targeted disruption, nervous system injury, sciatic nerve and spinal cord
5) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.39 Pain Relevance 0.90
CONCLUSIONS: These results indicate that the chronic treatment with morphine leads to alterations in nNOS expression in important regions implicated in the physical tolerance and dependence to opiates and suggest the use of specific inhibitors of this isoform in these conditions.


Regulation (alterations) of Gene_expression (expression) of nNOS
6) Confidence 0.54 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10663419 Disease Relevance 0.06 Pain Relevance 0
Effect of spinal nerve injury on nNOS expression in the DRG and spinal cord
Regulation (Effect) of Gene_expression (expression) of nNOS in spinal cord associated with dorsal root ganglion, nervous system injury and spinal cord
7) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.25 Pain Relevance 0.54
Peripheral nerve injury insult has distinct effects on nNOS expression in the DRG and dorsal horn.
Regulation (effects) of Gene_expression (expression) of nNOS in dorsal horn associated with dorsal root ganglion, nervous system injury, dorsal horn and peripheral nerve injury
8) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.30 Pain Relevance 0.71
In this sense, it has been reported that: 1- different regions behave differently during aging and/or degeneration [16]; 2- nNOS expression and synthesis can be regulated by Ca2+fluxes independently from nNOS activity especially in the hippocampus [24]; (c) there is a post-transcriptional regulation of nNOS expression in the brain of SAM [17].
Regulation (regulation) of Gene_expression (expression) of nNOS in hippocampus associated with aging and hippocampus
9) Confidence 0.52 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.32 Pain Relevance 0.23
Deletion of the nNOS gene not only eliminates nNOS protein, but in common with many gene deletions, affects several 'down-stream' processes.
Regulation (affects) of Gene_expression (Deletion) of nNOS gene
10) Confidence 0.45 Published 2005 Journal Novartis Found. Symp. Section Abstract Doc Link 16206879 Disease Relevance 0.44 Pain Relevance 0.11
These results indicated that the compensatory changes in the spinal cord expression of NOS3 in NOS1-KO under basal conditions does not fully compensate for NOS1 function in neuropathic pain, which is mainly produced by NOS2.
Neg (not) Regulation (compensate) of Gene_expression (expression) of NOS1 in spinal cord associated with targeted disruption, neuropathic pain and spinal cord
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.11 Pain Relevance 0.92
These data suggest that the increased spinal cord expression of NOS1, regulated by NOS2, might be responsible for the maintenance of chronic peripheral neuropathic pain in mice and propose these enzymes as interesting therapeutic targets for their treatment.



Spec (might) Regulation (responsible) of Gene_expression (expression) of NOS1 in spinal cord associated with neuropathic pain and spinal cord
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.52 Pain Relevance 0.97
Another interesting finding in the present study is the correlation between nNOS and eNOS expression in the placebo, but not in the ketorolac treatment group, which suggests an inhibitory effect of ketorolac on eNOS gene expression.
Regulation (correlation) of Gene_expression (expression) of nNOS associated with acular
13) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.47 Pain Relevance 0.58
OBJECTIVE: The present study was undertaken to determine the effect of chronic morphine treatment and abstinence on the expression of neuronal NO synthase (neuronal NOS, nNOS) in several brain regions of mice.
Spec (determine) Regulation (effect) of Gene_expression (expression) of nNOS in brain
14) Confidence 0.39 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10663419 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVE: The present study was undertaken to determine the effect of chronic morphine treatment and abstinence on the expression of neuronal NO synthase (neuronal NOS, nNOS) in several brain regions of mice.
Spec (determine) Regulation (effect) of Gene_expression (expression) of neuronal NOS in brain
15) Confidence 0.39 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10663419 Disease Relevance 0.10 Pain Relevance 0
The evidence described above indicates that peripheral nerve injury up-regulates expression and activity of nNOS in small DRG neurons and down-regulates its expression and activity in the spinal cord.
Regulation (regulates) of Gene_expression (expression) of nNOS in peripheral nerve associated with dorsal root ganglion, nervous system injury, spinal cord and peripheral nerve injury
16) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.20 Pain Relevance 0.92
Like eNOS, the expression of the ‘constitutive’ nNOS can be regulated in response of neuronal cells to stress [2].
Regulation (regulated) of Gene_expression (expression) of nNOS in neuronal associated with stress
17) Confidence 0.37 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.57 Pain Relevance 0.09
(ii) Is the role of nNOS species-dependent?
Regulation (role) of Gene_expression (species) of nNOS
18) Confidence 0.37 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.02 Pain Relevance 0.08
Ca2+-CaM then increases and activates CaMKII (13) that, in turn, acts on nNOS Ser847 to reduce Ca2+-CaM binding and NO production (14).
Regulation (acts) of Neg (NO) Gene_expression (production) of nNOS
19) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.45
Naloxone, an opioid antagonist, inhibits the effects of morphine on Akt-nNOS activation, indicating the involvement of MORs (not shown).


Regulation (effects) of Gene_expression (activation) of nNOS associated with antagonist, narcan, opioid and morphine
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.96

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