INT64113

Context Info Confidence 0.60 First Reported 1996 Last Reported 2011 Negated 10 Speculated 5 Reported most in Abstract Documents 110 Total Number 115 Disease Relevance 71.03 Pain Relevance 29.72

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1) cytoplasm (NOS1)

Anatomy Link Frequency brain 18 neuronal 12 forearm 10 phagocyte 8 heart 8 NOS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Migraine 411 100.00 cytokine 399 100.00 Spinal cord 221 100.00 depression 86 100.00 Inflammatory mediators 41 100.00 Nerve growth factor 31 100.00 Neuronal nitric oxide synthase 24 100.00 tetrodotoxin 3 99.98 Inflammation 836 99.92 Versed 10 99.92

Disease Link Frequency Relevance Heat Stress 1162 100.00 INFLAMMATION 1000 100.00 Disease 679 100.00 Headache 414 100.00 Targeted Disruption 112 100.00 Depression 86 100.00 Periodontitis 32 99.96 Arthritis 121 99.84 Drug Induced Neurotoxicity 23 99.84 Nervous System Injury 79 99.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSION: Fluoxetine, an antidepressant, renormalizes dendrite atrophy of hippocampal neurons by inhibiting nitric oxide synthase overexpression in rat chronic mild stress model.

Positive_regulation (overexpression) of Gene_expression (overexpression) of nitric oxide synthase in neurons

1) Confidence 0.60 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749766 Disease Relevance 0.14 Pain Relevance 0

Penile NOS content may be pharmacologically increased by: d) induction of NOS expression, and e) gene therapy with NOS cDNA.

Positive_regulation (induction) of Gene_expression (expression) of NOS

2) Confidence 0.59 Published 2000 Journal Drugs Today Section Abstract Doc Link 12879114 Disease Relevance 0.47 Pain Relevance 0.09

Many investigators have reported increased expression of endothelial NOS in the glandular endometrium in patients with endometriosis [28,130].

Positive_regulation (increased) of Gene_expression (expression) of NOS in endometrium associated with endometriosis

3) Confidence 0.53 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.26 Pain Relevance 0.66

Expression of NOS is elevated in patients with endometriosis, and a common polymorphism of exon 7 at nucleotide 894 in the endothelial NOS gene may be associated with endometriosis [135].

Positive_regulation (elevated) of Gene_expression (Expression) of NOS associated with endometriosis

4) Confidence 0.53 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.19 Pain Relevance 0.63

Peritoneal fluid NO levels, peritoneal macrophage NOS activity, and peritoneal macrophage inducible NOS protein expression has been examined in women with endometriosis-associated infertility.

Positive_regulation (inducible) of Gene_expression (expression) of NOS in peritoneal macrophage associated with endometriosis and reprotox - general 3

5) Confidence 0.53 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.89 Pain Relevance 0.39

Similarly, increased expression of nNOS (De Oliviera et al 2000) and iNOS (Madrigal et al 2001, 2003) has been noted to occur in limbic brain regions following acute restraint stress in rats.

Positive_regulation (increased) of Gene_expression (expression) of nNOS in brain associated with stress

6) Confidence 0.49 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.85 Pain Relevance 0.32

GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.

Positive_regulation (overexpression) of Gene_expression (overexpression) of nNOS

7) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.15

GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.

Positive_regulation (6-OHDA-induced) of Gene_expression (overexpression) of nNOS

8) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16

GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.

Positive_regulation (induced) of Gene_expression (overexpression) of nNOS in phagocyte

9) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.88 Pain Relevance 0.20

GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.

Positive_regulation (overexpression) of Gene_expression (overexpression) of nNOS in phagocyte

10) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.87 Pain Relevance 0.20

GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.

Positive_regulation (overexpression) of Gene_expression (overexpression) of neuronal nitric-oxide synthase in phagocyte

11) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.87 Pain Relevance 0.20

GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.

Positive_regulation (induced) of Gene_expression (overexpression) of neuronal nitric-oxide synthase in phagocyte

12) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.87 Pain Relevance 0.20

The availability of selective nNOS inhibitors, as well as studies in gene-modified mice with perturbation of nNOS expression, have provided evidence that nonneuronal nNOS is physiologically active and exerts important regulatory influences in a number of different tissues.

Positive_regulation (perturbation) of Gene_expression (expression) of nNOS

13) Confidence 0.44 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.07 Pain Relevance 0.25

Taken together, these findings suggest that NO derived from nNOS may have an important role in maintaining blood flow in the exercising skeletal muscle by reducing ?

Neg (NO) Positive_regulation (derived) of Neg (NO) Gene_expression (derived) of nNOS in blood

14) Confidence 0.44 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.49 Pain Relevance 0.13

In this context, experimental evidence revealed that increased activity and expression of nNOS may occur earlier than four hours in the paraventricular nucleus of rats subjected to lipopolysaccharide injection [27].

Positive_regulation (increased) of Gene_expression (expression) of nNOS in nucleus

15) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.30 Pain Relevance 0

In heart failure low NO levels are found proportionally to the severity of disease: the expression of No is depressed, but cytokine mediated i NOS expression is enhanced, causing exaggerated amounts of NO and producing myocyte damage or death.

Positive_regulation (enhanced) of Gene_expression (expression) of NOS in myocyte associated with disease, death, myocardial infarction and cytokine

16) Confidence 0.41 Published 2000 Journal Minerva Cardioangiol Section Abstract Doc Link 11214429 Disease Relevance 0.83 Pain Relevance 0.12

In heart failure low NO levels are found proportionally to the severity of disease: the expression of No is depressed, but cytokine mediated i NOS expression is enhanced, causing exaggerated amounts of NO and producing myocyte damage or death.

Positive_regulation (mediated) of Gene_expression (expression) of NOS in myocyte associated with disease, death, myocardial infarction and cytokine

17) Confidence 0.41 Published 2000 Journal Minerva Cardioangiol Section Abstract Doc Link 11214429 Disease Relevance 0.83 Pain Relevance 0.12

These results suggest that inducible NOS is constitutively expressed in human duodenal enterocytes, is increased in patients with untreated celiac disease, and is partially corrected when such patients are treated.

Positive_regulation (increased) of Gene_expression (expressed) of NOS in enterocytes associated with celiac disease

18) Confidence 0.41 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12121878 Disease Relevance 0.53 Pain Relevance 0.07

CONCLUSION: These results suggest that the expression of NOS mainly contributes to the allergic symptoms.

Positive_regulation (contributes) of Gene_expression (expression) of NOS

19) Confidence 0.40 Published 2000 Journal Cornea Section Body Doc Link 10632015 Disease Relevance 0 Pain Relevance 0

Additional experiments demonstrated that acupuncture increased the level of iNOS mRNA in macrophages [44] and while examining the distributions of NO in the skin points of rats it was shown that NO contents and nNOS expression were consistently higher in the skin acupoints/meridians associated with low electric resistance [45].

Positive_regulation (higher) of Gene_expression (expression) of nNOS in skin associated with acupuncture

20) Confidence 0.39 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1180462 Disease Relevance 0.15 Pain Relevance 0.28

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