INT64147

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 16.80
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5) response to stress (C5)
Anatomy Link Frequency
nerve 2
cleavage 2
neutrophil 1
C5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 334 99.80 Very High Very High Very High
rheumatoid arthritis 320 98.84 Very High Very High Very High
Sciatica 2 98.84 Very High Very High Very High
qutenza 10 85.76 High High
Thoracotomy 2 80.00 Quite High
Pain 10 69.04 Quite High
Inflammation 58 66.88 Quite High
medulla 10 59.68 Quite High
Analgesic 2 44.72 Quite Low
cINOD 4 43.52 Quite Low
Disease Link Frequency Relevance Heat
Cough 459 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 288 99.80 Very High Very High Very High
Aspiration Pneumonia 94 99.24 Very High Very High Very High
Nerve Root Compression 6 99.20 Very High Very High Very High
Rheumatoid Arthritis 322 98.84 Very High Very High Very High
Flavivirus Infection 160 98.28 Very High Very High Very High
Dengue 208 97.96 Very High Very High Very High
Infection 94 97.68 Very High Very High Very High
Disease 194 97.28 Very High Very High Very High
Cadaver 8 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study defines the TRAF1/C5 as a novel genetic region present in the human genome that predisposes to RA.
Gene_expression (/) of C5 associated with rheumatoid arthritis
1) Confidence 0.60 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.86 Pain Relevance 0.17
The lack of consistency between studies of TRAF1/C5 region and JIA susceptibility may be due to the lack of power of individual studies to detect the modest effect sizes reported at this locus.
Gene_expression (region) of C5 associated with arthritis
2) Confidence 0.56 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.64 Pain Relevance 0.32
TRAF1/C5: Three SNPs located in the TRAF1/C5 region were identified for investigation, one of which (rs10818488) showed the strongest evidence for association with Dutch RA cases.15 The other two SNPs, rs3761847 and rs2900180, showed the strongest evidence for association in North American and Swedish RA cases.16
Gene_expression (region) of C5 associated with rheumatoid arthritis
3) Confidence 0.56 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.81 Pain Relevance 0.40
A second, small study of SNPs within TRAF1/C5 region in USA JIA cases also reported association with this region.
Gene_expression (region) of C5 associated with arthritis
4) Confidence 0.56 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.89 Pain Relevance 0.44
For example, a recent study of Dutch JIA cases and controls investigated the rs10818488 SNP in the TRAF1/C5 region,27 and found no evidence for association of this SNP in patients with JIA as a whole.
Spec (investigated) Gene_expression (region,27) of C5 associated with arthritis
5) Confidence 0.56 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 1.28 Pain Relevance 0.64
In the study, all patients with aspiration pneumonia did not cough at C2/2, and 6 of 8 did not at C5/2.
Gene_expression (at) of C5 associated with cough and aspiration pneumonia
6) Confidence 0.53 Published 2008 Journal Cough Section Body Doc Link PMC2600632 Disease Relevance 3.03 Pain Relevance 0.03
As shown in Figure 2A, the cough reflex threshold to citric acid, as expressed by log C5, in patients with aspiration pneumonia (1.6 ± 0.5 g/l) was significantly higher than those of control (1.0 ± 0.4 g/l, p < 0.05).
Gene_expression (expressed) of C5 associated with cough and aspiration pneumonia
7) Confidence 0.53 Published 2008 Journal Cough Section Body Doc Link PMC2600632 Disease Relevance 2.41 Pain Relevance 0
Our findings indicate that a polymorphism in the TRAF1/C5 region increases the susceptibility to and severity of RA, possibly by influencing the structure, function, and/or expression levels of TRAF1 and/or C5.



Gene_expression (expression) of C5 associated with rheumatoid arthritis
8) Confidence 0.47 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1976626 Disease Relevance 0.88 Pain Relevance 0.36
In addition, they also found that the C5 element of the LTN did not join with C6 and C7 and traveled directly to the serratus anterior muscle in 6% of cases.
Gene_expression (element) of C5 in LTN
9) Confidence 0.40 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1920511 Disease Relevance 0.08 Pain Relevance 0.04
Long thoracic nerve variations were present as were the absence of C5 or C7 involvement and late C7 union with C5–C6;
Neg (absence) Gene_expression (absence) of C5 in nerve
10) Confidence 0.36 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1920511 Disease Relevance 0.40 Pain Relevance 0.07
We found that in those subjects with chronic cough the geometric mean (logSEM) mannitol C2 and C5 was heightened compared to controls (C2: 4 (0.2) versus 16 (0.1); p = 0.04 and C5: 63 (0.1) versus 251 (0.1); p = 0.04).
Gene_expression (heightened) of C5 associated with cough
11) Confidence 0.28 Published 2008 Journal Cough Section Abstract Doc Link PMC2596167 Disease Relevance 1.35 Pain Relevance 0.09
We also measured the plasma levels of C3a, a product of C3 cleavage, and C5a, a product of C5 cleavage, in samples from patients with confirmed dengue infection and different clinical diagnoses (Figure 2).
Gene_expression (product) of C5 in cleavage associated with dengue and infection
12) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.73 Pain Relevance 0
Modulation of the complement effector functions: inhibiting C5 activation and neutrophil migration
Gene_expression (activation) of C5 in neutrophil
13) Confidence 0.19 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.17 Pain Relevance 0
In a pioneering study, Bokisch et al. [3] measured the levels of nine complement factors (C1q, C1s, C2, C3, C4, C5, C6, C8 and factor B) in serum samples of DHF patients (grades I to IV).
Gene_expression (levels) of C5 associated with flavivirus infection
14) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.43 Pain Relevance 0
The cleavage products of C5 are C5a, a potent chemoattractant, and C5b that initiates the lytic pathway.
Gene_expression (products) of C5 in cleavage
15) Confidence 0.17 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.09 Pain Relevance 0
To identify the various electrodiagnostic (EDX) patterns of C-5, C-6, C-7, and C-8 cervical radiculopathy, we compared 50 cases of surgically proven solitary-root lesions with their preoperative EDX patterns.
Gene_expression (patterns) of C-5 associated with nerve root compression and sciatica
16) Confidence 0.13 Published 1996 Journal Neurology Section Abstract Doc Link 8780083 Disease Relevance 0.54 Pain Relevance 0.16
C5 convertase cleaves C5 into C5a and C5b.
Gene_expression (cleaves) of C5
17) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.11 Pain Relevance 0.03
C5 convertase cleaves C5 into C5a and C5b.
Gene_expression (cleaves) of C5
18) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.11 Pain Relevance 0.03

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