INT64157

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Context Info
Confidence 0.44
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.09
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPCAM)
Anatomy Link Frequency
blood 1
SVR 1
EPCAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 44 100.00 Very High Very High Very High
Endogenous opioid 12 99.68 Very High Very High Very High
qutenza 8 98.96 Very High Very High Very High
Inflammation 79 97.28 Very High Very High Very High
Enkephalin 8 92.80 High High
narcan 20 91.76 High High
Dynorphin 8 88.08 High High
anesthesia 7 86.92 High High
Opioid 8 86.52 High High
Analgesic 52 85.36 High High
Disease Link Frequency Relevance Heat
Disease 83 100.00 Very High Very High Very High
Ovarian Cancer 34 98.60 Very High Very High Very High
Anaemia 173 98.02 Very High Very High Very High
Cancer 146 97.70 Very High Very High Very High
INFLAMMATION 80 97.28 Very High Very High Very High
Sprains And Strains 156 96.40 Very High Very High Very High
Pneumoperitoneum 3 96.28 Very High Very High Very High
Ulcers 4 95.84 Very High Very High Very High
Pressure And Volume Under Development 118 95.00 High High
Lung Cancer 9 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both 2 and 100 Hz ESA groups, stepping force was increased significantly in similar degrees (p<0.05).
Positive_regulation (increased) of ESA
1) Confidence 0.44 Published 2007 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2693606 Disease Relevance 1.05 Pain Relevance 0.38
Results were negative for carcinoembrionary antigen and the epithelial glycoprotein Ber-EP4, whereas results were positive for the mesothelial markers cytokeratins, calretinin, epithelial membrane antigen, and HBME-1, thus leading to the correct diagnosis of peritoneal epithelial mesothelioma.
Positive_regulation (negative) of epithelial glycoprotein Ber-EP4 associated with lung cancer
2) Confidence 0.38 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1241930 Disease Relevance 0.67 Pain Relevance 0.06
Hemodynamic responses to peritoneal insufflation resulted in significant increases in systemic vascular resistance (SVR) as well as endsystolic area (ESA) and significant decreases in cardiac index (CI) and ejection fraction area (EFa) compared with baseline.
Positive_regulation (increases) of ESA in SVR
3) Confidence 0.38 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780267 Disease Relevance 0.53 Pain Relevance 0.16
Although the mechanism underlying ESA is not clear, it has been demonstrated that ESA is mediated by the endogenous opioids system and ESA at 2 Hz facilitates the release of ?
Positive_regulation (underlying) of ESA associated with endogenous opioid
4) Confidence 0.32 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.83 Pain Relevance 1.37
Although the mechanism underlying ESA is not clear, it has been demonstrated that ESA is mediated by the endogenous opioids system and ESA at 2 Hz facilitates the release of ?
Positive_regulation (mediated) of ESA associated with endogenous opioid
5) Confidence 0.32 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.76 Pain Relevance 1.36
In 2 and 100 Hz ESA groups, the % recovery of stepping force was significantly (p<0.05) increased at 1 and 2 hr after post-ESA compared to the values at pre-ESA.
Positive_regulation (increased) of ESA
6) Confidence 0.29 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.78 Pain Relevance 0
In conclusion, the current, along with previously reported data, show a strikingly increased incidence of CD in the KSA.
Positive_regulation (increased) of KSA associated with crohn's disease
7) Confidence 0.25 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702976 Disease Relevance 1.30 Pain Relevance 0.39
In this context the therapeutic goal is to reduce the need for blood transfusion.Epoetin beta should not be used prophylactically to prevent anemia nor is epoetin beta approved for cancer-associated anemia in patients not receiving chemotherapy.Where chemotherapy is given with curative intent the risk:benefit ratio of epoetin therapy may be unfavorable and transfusion should be preferred.In all settings the risk:benefit ratio of transfusion versus epoetin therapy should be discussed with the patient.Patients should be iron replete and intravenous iron supplementation may be associated with enhanced response to ESA therapy.Epoetin beta dose should be titrated to the minimum which avoids need for transfusion as per the product label.Epoetin beta should be discontinued when Hb is >12 g/dL.Epoetin beta should be discontinued within 4 weeks of completing the course of chemotherapy.
Positive_regulation (response) of ESA in blood associated with anaemia and cancer
8) Confidence 0.11 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.40 Pain Relevance 0.08
If the patient is not anemic at the start of tumor therapy, anemia may ensue a month or more into a 3-month long period of chemotherapy like CHOP-14 × VI, and since response to ESA treatment is mostly seen only after about 4–6 weeks, the time that the patient benefits may be too short to warrant the cost.
Positive_regulation (response) of ESA associated with anaemia and cancer
9) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.87 Pain Relevance 0.08
In the automatic mode there was a significant increase of ESA and EDA (+13.8%; +6.0%) and a significant decrease of FAC (-10.9%).
Positive_regulation (increase) of ESA
10) Confidence 0.08 Published 1997 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 9138542 Disease Relevance 0.19 Pain Relevance 0.19
Although the serum CA-125, an ovarian cell surface glycoprotein (i.e. a mucin) of unknown biological significance, is elevated in >80% of patients with advanced epithelial ovarian cancer, this marker has a positive predictive value of <10% in early stage disease [3].
Positive_regulation (elevated) of surface glycoprotein associated with ovarian cancer and disease
11) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707611 Disease Relevance 1.72 Pain Relevance 0.16

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