INT64159

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 7
Speculated 1
Reported most in Abstract
Documents 90
Total Number 91
Disease Relevance 34.65
Pain Relevance 55.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
spinal cord 4
duct 2
neurons 2
Leydig cells 1
skeletal muscle 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2610 100.00 Very High Very High Very High
opioid receptor 818 100.00 Very High Very High Very High
agonist 204 100.00 Very High Very High Very High
tolerance 257 99.98 Very High Very High Very High
Morphine 1307 99.92 Very High Very High Very High
Hyperalgesia 150 99.84 Very High Very High Very High
qutenza 255 99.82 Very High Very High Very High
Peripheral nerve injury 18 99.82 Very High Very High Very High
long-term potentiation 98 99.76 Very High Very High Very High
Acute pain 1 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 60 100.00 Very High Very High Very High
Virus Diseases 94 99.94 Very High Very High Very High
Apoptosis 174 99.92 Very High Very High Very High
Hyperalgesia 189 99.84 Very High Very High Very High
Targeted Disruption 189 99.84 Very High Very High Very High
Nervous System Injury 208 99.82 Very High Very High Very High
Pain 262 99.76 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 27 99.76 Very High Very High Very High
Injury 745 99.56 Very High Very High Very High
Neuropathic Pain 184 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether chronic morphine or clonidine treatment alters spinal PKC activity, the present studies measured PKC activity and expression of PKC isoform proteins in spinal cord cytosol and membrane fractions.
Gene_expression (expression) of PKC in spinal cord associated with kinase c, spinal cord, clonidine and morphine
1) Confidence 0.78 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.09
To understand the biochemical mechanisms involved in spinal anesthesia, we measured protein kinase C (PKC) activity and expression of immediate early oncogene protein, c-Fos, in the spinal cord.
Gene_expression (expression) of PKC in spinal cord associated with kinase c, anesthesia and spinal cord
2) Confidence 0.78 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.70
We report that cocaine disrupts signal transduction in PC 12 cells by altering the expression and activity of PKC isoforms and Ca2+ levels.
Gene_expression (expression) of PKC associated with kinase c and cocaine
3) Confidence 0.77 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668681 Disease Relevance 0.16 Pain Relevance 0.70
For the in vitro studies, the expression and activity of protein kinase C (PKC) isoforms and Ca2+ levels were examined following the incubation of PC 12 cells with cocaine.
Spec (examined) Gene_expression (expression) of PKC associated with kinase c and cocaine
4) Confidence 0.77 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668681 Disease Relevance 0.06 Pain Relevance 0.77
Considering that PKC-beta I and -beta II are coexpressed with PKC-alpha in mouse medullary collecting duct, the present results indicate that conventional PKC isoenzymes cannot fully compensate for each other.
Gene_expression (coexpressed) of PKC-alpha in duct associated with kinase c
5) Confidence 0.73 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15039142 Disease Relevance 0.05 Pain Relevance 0.59
Induction of morphine tolerance produced a 2-fold lower Km value for PKC (8.24 +/- 1.67 microM in placebo pellet vs 4.43 +/- 1.24 microM in morphine pellet) in cytosol, but not membrane fractions from spinal cord.
Gene_expression (produced) of PKC in spinal cord associated with kinase c, tolerance, spinal cord and morphine
6) Confidence 0.68 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.61
In conclusion, PKC-alpha appears not to play a major role in renal sodium reabsorption but, consistent with its expression in the medullary collecting duct, contributes to urinary concentration in mice.
Gene_expression (expression) of PKC-alpha in duct associated with kinase c
7) Confidence 0.63 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15039142 Disease Relevance 0.06 Pain Relevance 0.70
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Gene_expression (levels) of PKCalpha in spinal cord associated with spinal cord
8) Confidence 0.56 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.82
We analysed the protein expression of PKC and its activity, and G-protein activity of mu opioid receptor (MOR) under repeated morphine treatment with or without formalin treatment.
Gene_expression (expression) of PKC
9) Confidence 0.56 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20663033 Disease Relevance 0.09 Pain Relevance 0
The administration of PKC activators, such as PMA and PDBu, did not produce any effect on FMPH effect.
Neg (not) Gene_expression (produce) of PKC associated with kinase c
10) Confidence 0.55 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15223308 Disease Relevance 0.66 Pain Relevance 1.10
In retrospect, all these Cabp5-expressing cells appeared to be rod bipolar cells, based on high expression of the rod bipolar cell markers Prkca (Greferath et al., 1990) and Og9x.
Gene_expression (expression) of Prkca in rod bipolar cell
11) Confidence 0.54 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
How could BDV P interfere with PKC-dependent phosphorylation in neurons?
Gene_expression (interfere) of PKC in neurons associated with virus diseases and kinase c
12) Confidence 0.53 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.59 Pain Relevance 0.62
Under these conditions, the levels of membrane-bound phosphorylated-PKC in the limbic forebrain was clearly up-regulated by intermittent morphine treatment.
Gene_expression (levels) of phosphorylated-PKC in forebrain associated with kinase c and morphine
13) Confidence 0.52 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955717 Disease Relevance 0 Pain Relevance 1.17
However, the protein levels of PKCalpha, betaI, betaII and epsilon were not affected in the same preparation.
Gene_expression (levels) of PKCalpha
14) Confidence 0.51 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.07 Pain Relevance 0.88
Protein kinase C (PKC) activities were markedly reduced in diabetic transgenic mice, and the changes were associated with reduced expression of membrane PKC-alpha isoform that was translocated to cytosol.
Gene_expression (expression) of PKC-alpha associated with targeted disruption, kinase c and diabetes mellitus
15) Confidence 0.47 Published 2004 Journal Diabetes Section Abstract Doc Link 15561956 Disease Relevance 1.84 Pain Relevance 0.41
Involvement of kappa opioid receptors in the inhibition of receptor desensitization and PKC activation induced by repeated morphine treatment.
Gene_expression (activation) of PKC associated with kappa opioid receptor and morphine
16) Confidence 0.47 Published 2008 Journal J. Pharm. Pharmacol. Section Title Doc Link 18718122 Disease Relevance 0.09 Pain Relevance 2.04
These results highly indicated that MDZ-induced steroidogenesis in mouse Leydig cells via PKA and PKC pathways, along with the expression of PBR and StAR proteins.
Gene_expression (pathways) of PKC in Leydig cells associated with versed
17) Confidence 0.46 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 19857560 Disease Relevance 0.32 Pain Relevance 0.74
We conclude that all four major expressed PKC isoforms play distinct non-redundant roles, where the conventional PKCs promote and the novel PKCs inhibit thrombus formation on collagen, by a variety of mechanisms (summarized in Fig. 8C).
Gene_expression (expressed) of PKC associated with kinase c and thrombosis
18) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.33 Pain Relevance 0.47
also leads to enhanced secretion, calcium signaling, and phosphatidylserine exposure, the absence of PKC?
Neg (absence) Gene_expression (absence) of PKC associated with kinase c
19) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.32 Pain Relevance 0.50
The PKC?
Gene_expression (The) of PKC associated with kinase c
20) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.08 Pain Relevance 0.46

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