INT64160

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.01
Pain Relevance 4.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
spinal cord 4
IB4 4
rod bipolar cell 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 122 100.00 Very High Very High Very High
anesthesia 8 99.90 Very High Very High Very High
Spinal cord 5 99.16 Very High Very High Very High
Clonidine 11 98.82 Very High Very High Very High
Morphine 12 98.56 Very High Very High Very High
intrathecal 1 91.28 High High
Calcitonin gene-related peptide 61 91.20 High High
substance P 16 88.32 High High
Pain 19 87.56 High High
Antinociceptive 13 86.04 High High
Disease Link Frequency Relevance Heat
Injury 55 99.48 Very High Very High Very High
Targeted Disruption 26 99.12 Very High Very High Very High
Diabetes Mellitus 12 98.90 Very High Very High Very High
Parkinson's Disease 116 96.04 Very High Very High Very High
Pain 19 87.56 High High
Reperfusion Injury 30 86.84 High High
Cv Unclassified Under Development 68 83.36 Quite High
Nociception 64 82.00 Quite High
Hyperalgesia 9 78.92 Quite High
Neuropathic Pain 2 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether chronic morphine or clonidine treatment alters spinal PKC activity, the present studies measured PKC activity and expression of PKC isoform proteins in spinal cord cytosol and membrane fractions.
Negative_regulation (measured) of Gene_expression (expression) of PKC in spinal cord associated with kinase c, spinal cord, clonidine and morphine
1) Confidence 0.43 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.09
To understand the biochemical mechanisms involved in spinal anesthesia, we measured protein kinase C (PKC) activity and expression of immediate early oncogene protein, c-Fos, in the spinal cord.
Negative_regulation (measured) of Gene_expression (expression) of PKC in spinal cord associated with kinase c, anesthesia and spinal cord
2) Confidence 0.43 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.70
Protein kinase C (PKC) activities were markedly reduced in diabetic transgenic mice, and the changes were associated with reduced expression of membrane PKC-alpha isoform that was translocated to cytosol.
Negative_regulation (reduced) of Gene_expression (expression) of PKC-alpha associated with targeted disruption, kinase c and diabetes mellitus
3) Confidence 0.36 Published 2004 Journal Diabetes Section Abstract Doc Link 15561956 Disease Relevance 1.84 Pain Relevance 0.41
In retrospect, all these Cabp5-expressing cells appeared to be rod bipolar cells, based on high expression of the rod bipolar cell markers Prkca (Greferath et al., 1990) and Og9x.
Negative_regulation (appeared) of in rod bipolar cells Gene_expression (expression) of Prkca in rod bipolar cell
4) Confidence 0.29 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Effects of PKC and p42/44 MAPK inhibitors on TNF-?
Negative_regulation (inhibitors) of Gene_expression (Effects) of PKC associated with kinase c
5) Confidence 0.22 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.10 Pain Relevance 0.13
To evaluate the actions of PKC and p42/44 MAPK in vivo, mice were treated with either C21H18NO4Cl (5 mg/kg) 30 min or U0126 (25 ?
Negative_regulation (evaluate) of Gene_expression (actions) of PKC associated with kinase c
6) Confidence 0.22 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.10 Pain Relevance 0.16
Double staining for IB4, on coverslips previously processed for PKC?
Negative_regulation (previously) of Gene_expression (processed) of PKC in IB4
7) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.16
Double staining for IB4, on coverslips previously processed for PKC?
Negative_regulation (coverslips) of Gene_expression (processed) of PKC in IB4
8) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.16
/PKC pathway: intracellular calcium release, sensitisation of TRPV1, and translocation of the epsilon isoform of PKC (PKC?)
Negative_regulation (sensitisation) of Gene_expression (pathway) of PKC
9) Confidence 0.09 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2956715 Disease Relevance 0.45 Pain Relevance 0.16
However, in our own studies we were unable to detect PKC?
Neg (unable) Negative_regulation (unable) of Neg (unable) Gene_expression (detect) of PKC associated with kinase c
10) Confidence 0.06 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.52 Pain Relevance 0.74

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