INT64161

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2011
Negated 3
Speculated 13
Reported most in Abstract
Documents 213
Total Number 227
Disease Relevance 85.06
Pain Relevance 129.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
spinal cord 14
spinal 5
brain 4
sensory neurons 3
sciatic nerve 3
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3604 100.00 Very High Very High Very High
Inflammation 860 100.00 Very High Very High Very High
opioid receptor 819 100.00 Very High Very High Very High
Spinal cord 261 100.00 Very High Very High Very High
Glutamate 174 100.00 Very High Very High Very High
nMDA receptor 154 100.00 Very High Very High Very High
depression 117 100.00 Very High Very High Very High
Clonidine 255 99.98 Very High Very High Very High
tolerance 468 99.96 Very High Very High Very High
Nerve growth factor 197 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 939 100.00 Very High Very High Very High
Depression 123 100.00 Very High Very High Very High
Hyperglycemia 86 100.00 Very High Very High Very High
Targeted Disruption 840 99.96 Very High Very High Very High
Insulin Resistance 203 99.90 Very High Very High Very High
Nervous System Injury 93 99.88 Very High Very High Very High
Hyperalgesia 459 99.82 Very High Very High Very High
Injury 363 99.82 Very High Very High Very High
Nociception 602 99.78 Very High Very High Very High
Drug Dependence 7 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine tolerance, but not clonidine tolerance, enhanced PKC activity while decreasing protein expression.
Positive_regulation (enhanced) of PKC associated with kinase c, tolerance, clonidine and morphine
1) Confidence 0.70 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.10
However, little direct evidence is available for the involvement of activated PKC in the spinal cord in reduction of rewarding effects induced by morphine under chronic pain-like state.
Positive_regulation (activated) of PKC in spinal cord associated with kinase c, lasting pain, morphine and spinal cord
2) Confidence 0.70 Published 2004 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15179546 Disease Relevance 0.28 Pain Relevance 0.90
CONCLUSION: The present findings suggest that activated PKC in the spinal cord with chronic pain-like hyperalgesia may play a substantial role in the suppression of the morphine-induced rewarding effect in mice with chronic pain-like hyperalgesia.


Spec (like) Positive_regulation (activated) of PKC in spinal cord
3) Confidence 0.70 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15179546 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVE: The present study was to investigate whether direct activation of spinal PKC by intrathecal (IT) administration of a specific PKC activator, phorbol 12,13-dibutyrate (PDBu) could produce hyperalgesia and suppress the place preference induced by morphine in mice.
Spec (whether) Positive_regulation (activation) of PKC in spinal
4) Confidence 0.70 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15179546 Disease Relevance 0.10 Pain Relevance 0
However, these results also demonstrate a lack of correlation between an increase in PKC levels and either potency or lipid solubility of the anesthetics.
Positive_regulation (increase) of PKC associated with kinase c and potency
5) Confidence 0.70 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.22
The increased PKC activity may not be the sole mechanism for spinal anesthesia.
Positive_regulation (increased) of PKC in spinal associated with anesthesia and kinase c
6) Confidence 0.70 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.20
The less lipid-soluble procaine produced a larger increase in PKC activity than did the more lipid-soluble tetracaine.
Positive_regulation (increase) of PKC associated with kinase c
7) Confidence 0.70 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.18
When compared to saline-treated controls, PKC activity was increased significantly (P < 0.0005) in procaine- and tetracaine-treated groups whereas ethanol decreased PKC activity.
Positive_regulation (increased) of PKC associated with kinase c
8) Confidence 0.70 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.02
These findings suggest that the up-regulation of G(q/11alpha)-dependent PKC activity in membranes of the limbic forebrain is implicated in the development of sensitization to morphine-induced hyperlocomotion in mice.
Positive_regulation (up-regulation) of PKC in forebrain associated with kinase c and morphine
9) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955717 Disease Relevance 0 Pain Relevance 1.11
These results indicate that the up-regulation of membrane-bound PKC following intermittent morphine treatment results from the increase in levels of G(q/11alpha) protein.
Positive_regulation (up-regulation) of PKC associated with kinase c and morphine
10) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955717 Disease Relevance 0 Pain Relevance 1.36
Our data indicate that the increase of inositol phosphate contents in striatum implied activation of phospholipase C, which might lead to PKC activation.
Spec (might) Positive_regulation (activation) of PKC in striatum
11) Confidence 0.69 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.21 Pain Relevance 0.90
This PKC activation may be involved in the development of morphine dependence.
Positive_regulation (activation) of PKC associated with addiction and morphine
12) Confidence 0.69 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.31 Pain Relevance 0.89
The membrane PKC activity was apparently enhanced in striatum but decreased in cerebellum and hippocampus. (3) PKC inhibitor was found to prevent the development of morphine dependence. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Positive_regulation (enhanced) of PKC in hippocampus associated with addiction, narcan, hippocampus and morphine
13) Confidence 0.69 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.25 Pain Relevance 0.95
But no similar changes in hippocampus and cerebellum were observed. (2) Cytosolic PKC activity was significantly increased in cerebellum and cerebral cortex but decreased in striatum.
Positive_regulation (increased) of PKC in striatum associated with hippocampus and cerebral cortex
14) Confidence 0.69 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.25 Pain Relevance 0.91
Here we first investigated whether sciatic nerve injury could change the activity of a conventional PKC (cPKC) and an atypical PKC isoform PKCzeta in the mouse spinal cord.
Positive_regulation (change) of PKC in spinal cord associated with kinase c, nervous system injury, sciatic nerve and spinal cord
15) Confidence 0.69 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.27 Pain Relevance 1.05
These results suggest that activation of PKCs, including cPKC and PKCzeta, within the spinal cord is directly responsible for the attenuation of the morphine-induced rewarding effect under a neuropathic pain-like state following sciatic nerve ligation in mice.
Positive_regulation (activation) of cPKC in sciatic nerve associated with neuropathic pain, sciatic nerve, morphine and spinal cord
16) Confidence 0.69 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.49 Pain Relevance 1.42
Here we first investigated whether sciatic nerve injury could change the activity of a conventional PKC (cPKC) and an atypical PKC isoform PKCzeta in the mouse spinal cord.
Positive_regulation (change) of PKC in spinal cord associated with kinase c, nervous system injury, sciatic nerve and spinal cord
17) Confidence 0.69 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.32 Pain Relevance 1.11
These data provide direct evidence that activated cPKC and PKCzeta in the spinal cord may contribute to the development and maintenance of neuropathic pain.
Positive_regulation (activated) of cPKC in spinal cord associated with neuropathic pain and spinal cord
18) Confidence 0.69 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.58 Pain Relevance 1.66
In this paper, we directly demonstrate, for the first time, the activation of Ca(2+)-dependent protein kinase C (PKC) in the spinal cord of diabetic mice.
Positive_regulation (activation) of PKC in spinal cord associated with kinase c, diabetes mellitus and spinal cord
19) Confidence 0.69 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17473449 Disease Relevance 0.71 Pain Relevance 0.58
Recently, we demonstrated that activated protein kinase C (PKC) in the spinal cord associated with chronic pain-like hyperalgesia suppressed the morphine-induced rewarding effect in mice.
Spec (like) Positive_regulation (activated) of PKC in spinal cord associated with hyperalgesia, kinase c, lasting pain, morphine and spinal cord
20) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18262361 Disease Relevance 0.59 Pain Relevance 1.47

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