INT64163

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 3.86
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
photoreceptors 2
spinal cord 2
skin 2
primary visual cortex 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 22 100.00 Very High Very High Very High
Kinase C 14 100.00 Very High Very High Very High
anesthesia 7 99.90 Very High Very High Very High
tetrodotoxin 18 99.84 Very High Very High Very High
metalloproteinase 9 99.76 Very High Very High Very High
agonist 23 99.74 Very High Very High Very High
adenocard 5 98.92 Very High Very High Very High
Spinal cord 3 98.68 Very High Very High Very High
Hippocampus 4 98.32 Very High Very High Very High
Glutamate 3 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 8 100.00 Very High Very High Very High
Aids-related Complex 3 100.00 Very High Very High Very High
Colon Cancer 12 99.76 Very High Very High Very High
Adhesions 25 98.04 Very High Very High Very High
Skin Cancer 18 97.48 Very High Very High Very High
INFLAMMATION 148 95.36 Very High Very High Very High
Breast Cancer 10 95.00 High High
Stress 19 93.96 High High
Cancer 89 89.84 High High
Apoptosis 40 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B was sufficient to downregulate expression of AP-1 (c-jun) and MMPs, which suggests signaling was from the NF-?
Negative_regulation (downregulate) of Gene_expression (expression) of AP-1 associated with metalloproteinase
1) Confidence 0.58 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.15 Pain Relevance 0.17
In addition to suppressing TNF-induced activation of AP-1 in a variety of cells, inhibiting TPA-induced expression of c-Fos and c-Jun in mouse skin, and inhibiting anchorage-independent growth of melanoma cells [18-20], resveratrol suppressed TPA-induced expression of MMP-9 by inhibition of AP-1 activation through c-Jun N-terminal kinase (JNK) and PKC-delta pathways [26] and protected against 4-hydroxynonenal-induced apoptosis by blocking AP-1 signaling through JNK [27].
Negative_regulation (inhibiting) of Gene_expression (expression) of c-Jun in skin associated with apoptosis and skin cancer
2) Confidence 0.43 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.28 Pain Relevance 0
B was sufficient to downregulate expression of AP-1 (c-jun) and MMPs, which suggests signaling was from the NF-?
Negative_regulation (downregulate) of Gene_expression (expression) of c-jun associated with metalloproteinase
3) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.15 Pain Relevance 0.17
To understand the biochemical mechanisms involved in spinal anesthesia, we measured protein kinase C (PKC) activity and expression of immediate early oncogene protein, c-Fos, in the spinal cord.
Negative_regulation (measured) of Gene_expression (expression) of immediate early in spinal cord associated with kinase c, anesthesia and spinal cord
4) Confidence 0.41 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.71
V-PYRRO/NO also suppressed the expression of acute phase protein genes and genes related to cell-death pathways, such as c-jun/AP-1, nuclear factor-kappaB, early response growth factor-1, heme oxygenase-1, caspase-3, growth arrest, and DNA-damaging protein-153.
Negative_regulation (suppressed) of Gene_expression (expression) of c-jun associated with death
5) Confidence 0.41 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.24
V-PYRRO/NO also suppressed the expression of acute phase protein genes and genes related to cell-death pathways, such as c-jun/AP-1, nuclear factor-kappaB, early response growth factor-1, heme oxygenase-1, caspase-3, growth arrest, and DNA-damaging protein-153.
Negative_regulation (suppressed) of Gene_expression (expression) of AP-1 associated with death
6) Confidence 0.41 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.24
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Negative_regulation (diminished) of Gene_expression (expression) of Jun
7) Confidence 0.40 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression.
Spec (possible) Negative_regulation (reduction) of Gene_expression (expression) of AP-1 associated with adenocard and enkephalin
8) Confidence 0.17 Published 2005 Journal Behav. Brain Res. Section Title Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.46
Likewise, luteolin down-regulated complement factor 3, which is regulated by AP1 [68] and blocked expression of Slpi, which is a target of interferon regulatory factor 1 (IRF1) [69].
Negative_regulation (blocked) of Gene_expression (expression) of AP1
9) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.34 Pain Relevance 0.15
In situ hybridization using the primary visual cortex (V1, Figure S6A) showed that the expression of the immediate early genes Arc and c-fos in the monocular regions of V1 was markedly suppressed by TTX treatment (Figure S6B, C), as reported previously [45], [46].
Negative_regulation (suppressed) of Gene_expression (expression) of immediate early in primary visual cortex associated with tetrodotoxin and aids-related complex
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.10 Pain Relevance 0.53
When compared to expression levels in the WT animal, the loss of photoreceptors resulted in reduced expression of the immediate early gene transcription factor cFos, as well as Slc1a3 and Grm1, a glutamate transporter and receptor, respectively.
Negative_regulation (reduced) of Gene_expression (expression) of immediate early in photoreceptors associated with glutamate
11) Confidence 0.04 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.09 Pain Relevance 0.05
Inhibition of AP-1 expression through suppression of the extracellular receptor kinase (ERK) MAPK pathway activity resulted in significant downregulation of the total level of sigma-1 receptors[14].
Negative_regulation (Inhibition) of Gene_expression (expression) of AP-1
12) Confidence 0.03 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.19 Pain Relevance 0.21
Inhibition of AP-1 expression through suppression of the extracellular receptor kinase (ERK) MAPK pathway activity resulted in significant downregulation of the total level of sigma-1 receptors[14].
Negative_regulation (suppression) of Gene_expression (expression) of AP-1
13) Confidence 0.02 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.19 Pain Relevance 0.21
agonist ciglitazone decreased the expression of COX2 and cJun in a colorectal cancer cell line [164].
Negative_regulation (decreased) of Gene_expression (expression) of cJun associated with colon cancer, agonist and cox2
14) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.77 Pain Relevance 0.65

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