INT64171

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 20
Speculated 14
Reported most in Abstract
Documents 109
Total Number 123
Disease Relevance 55.36
Pain Relevance 32.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
macrophages 3
monocyte 3
sperm 3
skeletal muscle 2
cartilage 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 847 100.00 Very High Very High Very High
COX-2 inhibitor 285 100.00 Very High Very High Very High
COX2 65 100.00 Very High Very High Very High
Inflammation 942 99.96 Very High Very High Very High
Paracetamol 14 99.84 Very High Very High Very High
cOX1 35 99.64 Very High Very High Very High
antagonist 143 99.54 Very High Very High Very High
diclofenac 286 99.36 Very High Very High Very High
Osteoarthritis 349 99.20 Very High Very High Very High
Neuropathic pain 27 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 336 100.00 Very High Very High Very High
Breast Cancer 23 100.00 Very High Very High Very High
INFLAMMATION 1220 99.96 Very High Very High Very High
Hypokinesia 6 99.76 Very High Very High Very High
Ulcers 46 99.74 Very High Very High Very High
Infection 230 99.64 Very High Very High Very High
Neuroblastoma 155 99.60 Very High Very High Very High
Neurodegenerative Disease 48 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 32 99.56 Very High Very High Very High
Stomach Cancer 31 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adverse effects of COX inhibitors on the cardiovascular system have been addressed in the last few years.
Regulation (effects) of COX in cardiovascular system
1) Confidence 0.36 Published 2010 Journal Vet. Pathol. Section Abstract Doc Link 20418470 Disease Relevance 0.47 Pain Relevance 0.38
Here we sought to elucidate the effect of COX inhibitors on doxorubicin-induced cytotoxicity in relation to P-gp function in human esophageal squamous cell carcinoma cells.
Regulation (effect) of COX associated with skin cancer
2) Confidence 0.30 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19264847 Disease Relevance 0.54 Pain Relevance 0.14
A brief review of the molecular biology, pharmacology, and primary actions of COX-2 outside of the nervous system provides a context for understanding potential neurobiological roles for COX-2 and prostanoid production.
Regulation (roles) of COX in nervous system
3) Confidence 0.30 Published 1999 Journal Crit Rev Neurobiol Section Abstract Doc Link 10223523 Disease Relevance 0.45 Pain Relevance 0.15
Two isoforms of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostanoids, are now recognized: a constitutively expressed COX-1 and a highly regulated COX-2.
Regulation (regulated) of COX
4) Confidence 0.30 Published 1999 Journal Crit Rev Neurobiol Section Abstract Doc Link 10223523 Disease Relevance 0.35 Pain Relevance 0.09
Of these models, the carrageenan-induced pleurisy model has been extensively used to study the role of the cyclooxygenase (COX) enzymes and the prostaglandins in acute inflammation and also for the screening of COX-inhibiting anti-inflammatory drugs.
Regulation (role) of COX associated with inflammation, pleurisy and cinod
5) Confidence 0.30 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20645176 Disease Relevance 1.06 Pain Relevance 0.45
Sulindac sulfide had little effect on COX-2 in this model, but did suppress prostaglandin synthase E2 production, presumably by inhibiting COX enzyme activity.
Neg (little) Regulation (effect) of COX
6) Confidence 0.30 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11118042 Disease Relevance 0.47 Pain Relevance 0.06
There was no effect on COX-1 and COX-2 activity.
Neg (no) Regulation (effect) of COX
7) Confidence 0.29 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.41 Pain Relevance 0.26
There was no effect on COX-1 and COX-2 activity.
Neg (no) Regulation (effect) of COX
8) Confidence 0.29 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.41 Pain Relevance 0.26
Aceclofenac and 4'-hydroxyaceclofenac are the major compounds in human blood after the administration of aceclofenac, but they had no inhibitory effects on cyclooxygenase (COX) activity or COX expression in the rheumatoid synovial cells.
Neg (no) Regulation (effects) of COX in synovial cells
9) Confidence 0.26 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215639 Disease Relevance 0.27 Pain Relevance 0.25
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Regulation (effect) of COX in macrophages associated with cinod
10) Confidence 0.26 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.39
The widespread consumption of diets rich in anthocyanin and catechin content prompted the evaluation of their in vitro inhibitory effects on cyclooxygenase (COX) enzymes and on the proliferation of human cancer cell lines.
Regulation (effects) of COX associated with cancer
11) Confidence 0.24 Published 2003 Journal Nutr Cancer Section Abstract Doc Link 12925310 Disease Relevance 0.17 Pain Relevance 0
Effect of red clover isoflavones on cox-2 activity in murine and human monocyte/macrophage cells.
Regulation (Effect) of cox in monocyte associated with cox2
12) Confidence 0.24 Published 2004 Journal Nutr Cancer Section Title Doc Link 15456640 Disease Relevance 0.33 Pain Relevance 0.15
The effects of NSAIDs (ibuprofen, piroxicam, and indomethacin), a COX-1 selective inhibitor (SC-560), and COX-2 selective inhibitors (celecoxib, niflumic acid, nimesulide, NS-398, and SC-58125) on aromatase activity and CYP19 expression were investigated in breast cancer cell culture systems.
Spec (investigated) Regulation (effects) of COX associated with breast cancer and cinod
13) Confidence 0.24 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.51 Pain Relevance 0.37
The effects of NSAIDs (ibuprofen, piroxicam, and indomethacin), a COX-1 selective inhibitor (SC-560), and COX-2 selective inhibitors (celecoxib, niflumic acid, nimesulide, NS-398, and SC-58125) on aromatase activity and CYP19 expression were investigated in breast cancer cell culture systems.
Spec (investigated) Regulation (effects) of COX associated with breast cancer and cinod
14) Confidence 0.24 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.51 Pain Relevance 0.37
A drug that specifically inhibits COX-2 without affecting COX-1 would, theoretically, reduce inflammation without leading to GI side effects.
Neg (without) Regulation (affecting) of COX associated with inflammation
15) Confidence 0.24 Published 1998 Journal J Rheumatol Suppl Section Abstract Doc Link 9596548 Disease Relevance 0.41 Pain Relevance 0.54
Nimesulide was highly selective against ovine Cox-2, so that at concentrations attained in vivo, it had no effect on Cox-1 but completely suppressed Cox-2.
Neg (no) Regulation (effect) of Cox
16) Confidence 0.24 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.23 Pain Relevance 0.24
Collectively, this assessment suggests potential involvement of PGs in the healing process of these tissues via modulation by non-selective NSAIDs and selective COX-2 inhibitors.
Regulation (modulation) of COX associated with cinod and cox-2 inhibitor
17) Confidence 0.22 Published 2005 Journal Inflamm. Res. Section Abstract Doc Link 16273333 Disease Relevance 0.20 Pain Relevance 0.38
COX isotype selective inhibitors were used to discern relative contributions of COX-1 and COX-2 activities to microglial PGE(2) secretion.
Regulation (contributions) of COX
18) Confidence 0.22 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.64 Pain Relevance 0.29
COX isotype selective inhibitors were used to discern relative contributions of COX-1 and COX-2 activities to microglial PGE(2) secretion.
Regulation (contributions) of COX
19) Confidence 0.22 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.64 Pain Relevance 0.29
There is now convincing evidence, obtained with a number of structurally distinct inhibitors, that selective COX-2 inhibitors possess anti-inflammatory effects with an improved gastrointestinal tolerability compared with conventional nonsteroidal anti-inflammatory drugs (NSAIDs) affecting both COX-1 and COX-2.
Regulation (affecting) of COX associated with inflammation, cinod and cox-2 inhibitor
20) Confidence 0.20 Published 1997 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9365818 Disease Relevance 0.27 Pain Relevance 0.68

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