INT64173

Context Info Confidence 0.37 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.89 Pain Relevance 0.88

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2) intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)

Anatomy Link Frequency macrophages 4 GLI2 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 8 100.00 aspirin 4 93.76 Mechanotransduction 16 83.56 COX2 2 25.00 Pain 2 5.00 metalloproteinase 2 5.00 anesthesia 1 5.00 agonist 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Cancer 124 100.00 Medulloblastoma 10 99.28 Hypertension 2 97.76 INFLAMMATION 4 92.40 Heart Disease 2 92.40 Repression 3 80.84 Metastasis 47 78.96 Breast Cancer 12 78.52 Osteolysis 6 56.24 Advanced Or Metastatic Breast Cancer 2 50.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mechanical signals induced by substrate rigidity regulate the expression of Gli2 and PTHrP though ROCK.

Regulation (regulate) of Gene_expression (expression) of Gli2

1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.97 Pain Relevance 0.04

Our observation that the expression of Gli2 by tumor cells is regulated by matrix rigidity is consistent with previous studies suggesting that Hh genes are regulated during development by mechanically transduced signals [43], [44].

Regulation (regulated) of Gene_expression (expression) of Gli2 associated with cancer

2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.00 Pain Relevance 0.04

Several promising cancer drugs that reduce medulloblastoma growth in mouse models purportedly interfere with Gli1 and Gli2 expression by blocking the signalling pathway downstream of Smo.

Regulation (interfere) of Gene_expression (expression) of Gli2 associated with cancer and medulloblastoma

3) Confidence 0.17 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.58 Pain Relevance 0

In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.

Regulation (effect) of Gene_expression (expression) of THP-1 in macrophages associated with cinod

4) Confidence 0.10 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.40

In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.

Regulation (effect) of Gene_expression (production) of THP-1 in macrophages associated with cinod

5) Confidence 0.10 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.40

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