INT64174

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Context Info
Confidence 0.18
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
Macrophages 2
epithelial cells 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 2 98.50 Very High Very High Very High
cINOD 6 89.40 High High
antagonist 13 69.36 Quite High
Spinal cord 12 31.56 Quite Low
COX2 3 25.00 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
allodynia 3 5.00 Very Low Very Low Very Low
central sensitization 1 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 6 96.12 Very High Very High Very High
Lung Cancer 2 94.20 High High
INFLAMMATION 7 80.84 Quite High
Cancer 1 53.12 Quite High
Neuroblastoma 22 50.00 Quite Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.
Negative_regulation (inhibition) of Transcription (expression) of COX in Macrophages associated with aspirin
1) Confidence 0.18 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.16 Pain Relevance 0.39
Treatment with COX-2 siRNAs decreased the expression of COX-2 mRNA; furthermore, the siCOX-2-mediated decrease also resulted in suppression of CYP19 mRNA.
Negative_regulation (decreased) of Transcription (expression) of COX
2) Confidence 0.13 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.50 Pain Relevance 0.14
In other studies ATRA did not induce COX-2 in phorbol 12-myristate 13-acetate-differentiated U937 cells [28] whereas it suppressed COX-2 transcription in human mammary epithelial cells [29].
Negative_regulation (suppressed) of Transcription (transcription) of COX in epithelial cells
3) Confidence 0.08 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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