INT64175

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 66
Total Number 69
Disease Relevance 39.64
Pain Relevance 23.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
Macrophages 15
SH-SY5Y 2
plasma 2
Cartilage 2
platelet 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 145 100.00 Very High Very High Very High
cINOD 478 99.98 Very High Very High Very High
dexamethasone 7 99.98 Very High Very High Very High
aspirin 173 99.88 Very High Very High Very High
Paracetamol 22 99.84 Very High Very High Very High
Inflammation 532 99.78 Very High Very High Very High
Potency 18 99.74 Very High Very High Very High
Pain 179 99.64 Very High Very High Very High
licofelone 107 99.64 Very High Very High Very High
qutenza 14 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 4 100.00 Very High Very High Very High
Apoptosis 235 99.90 Very High Very High Very High
INFLAMMATION 667 99.78 Very High Very High Very High
Osteoid Osteoma 10 99.72 Very High Very High Very High
Pain 207 99.64 Very High Very High Very High
Disease 218 99.40 Very High Very High Very High
Osteoarthritis 154 99.40 Very High Very High Very High
Cancer 449 99.28 Very High Very High Very High
Sepsis 16 99.08 Very High Very High Very High
Reprotox - General 1 119 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous application of an oxidant, H2O2, significantly prevented the Cap-induced apoptosis and suppressed the expression of COX isoforms.
Negative_regulation (suppressed) of Gene_expression (expression) of COX associated with qutenza and apoptosis
1) Confidence 0.38 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086397 Disease Relevance 0.72 Pain Relevance 0.80
Unlike the selective COX inhibitors 1-[(4-methylsulfonyl)phenyl]-3-trifluoromethyl-5-[(4-fluoro)phenyl]pyraz ole (SC 58125) and (2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (NS 398) that inhibit COX-2 catalytic activity, these antioxidants decreased COX-2 expression at the transcriptional level.
Negative_regulation (decreased) of Gene_expression (expression) of COX
2) Confidence 0.30 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9622066 Disease Relevance 0.60 Pain Relevance 0.07
Sulindac sulfone inhibited COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.
Negative_regulation (inhibited) of Gene_expression (expression) of COX
3) Confidence 0.28 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11118042 Disease Relevance 0.50 Pain Relevance 0.07
At present it is unclear whether nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit cyclooxygenase (COX) gene expression.
Negative_regulation (inhibit) of Gene_expression (expression) of COX associated with inflammation and cinod
4) Confidence 0.24 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.32
Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.
Negative_regulation (inhibition) of Gene_expression (expression) of COX in Macrophages associated with aspirin
5) Confidence 0.24 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.16 Pain Relevance 0.39
Most NSAIDs act upon local inflammatory events by inhibiting the expression or activation of cylooxygenase (COX).
Negative_regulation (inhibiting) of Gene_expression (expression) of COX associated with inflammation and cinod
6) Confidence 0.23 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11194936 Disease Relevance 0.86 Pain Relevance 0.34
Finally, treatment with COX-2 siRNAs downregulated the expression of COX-2 mRNA; furthermore, the siCOX-2-mediated suppression of COX-2 also resulted in suppression of aromatase mRNA.
Negative_regulation (downregulated) of Gene_expression (expression) of COX
7) Confidence 0.23 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.36 Pain Relevance 0.25
The expression of the PG synthesizing cyclooxygenase-2 (COX-2) gene was significantly decreased by calcitriol, while that of PG inactivating 15-prostaglandin dehydrogenase gene (15-PGDH) was increased.
Negative_regulation (decreased) of Gene_expression (expression) of COX
8) Confidence 0.22 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16024246 Disease Relevance 0.73 Pain Relevance 0.10
[Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors].
Negative_regulation (inhibitors) of Gene_expression (selective) of COX associated with aspirin and cox-2 inhibitor
9) Confidence 0.22 Published 2001 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 11577463 Disease Relevance 0.49 Pain Relevance 1.09
Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.
Negative_regulation (suppressed) of Gene_expression (expression) of COX associated with dexamethasone
10) Confidence 0.21 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.13 Pain Relevance 0.37
Other agents like non-steroidal anti-inflammatory drugs (NSAIDs) partly inhibit cyclooxygenase (COX) expression, as well as having a positive influence on the clinical expression of AD.
Negative_regulation (inhibit) of Gene_expression (expression) of COX associated with inflammation and cinod
11) Confidence 0.21 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060707 Disease Relevance 1.04 Pain Relevance 0.49
We further demonstrate that both a free radical scavenger and an inhibitor of p38 mitogen-activated protein kinase (MAPK) reduce IL-1beta-induced synthesis of COX-2.
Negative_regulation (reduce) of Gene_expression (synthesis) of COX
12) Confidence 0.20 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.48 Pain Relevance 0.12
Data from clinical pharmacology, rodent models, human genetics, observational studies and randomized trials provide insight into the implications of inhibiting COX product synthesis or function.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of COX
13) Confidence 0.20 Published 2009 Journal J. Thromb. Haemost. Section Abstract Doc Link 19630805 Disease Relevance 0.44 Pain Relevance 0.31
Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.
Negative_regulation (inhibition) of Gene_expression (production) of COX in Macrophages associated with aspirin
14) Confidence 0.18 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.16 Pain Relevance 0.39
Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.
Negative_regulation (inhibition) of Gene_expression (expression) of COX in Macrophages associated with aspirin
15) Confidence 0.18 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.16 Pain Relevance 0.39
Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.
Negative_regulation (inhibition) of Neg (not) Gene_expression (production) of COX in Macrophages associated with aspirin
16) Confidence 0.18 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.16 Pain Relevance 0.39
GLNVA also reduced cyclooxygenase (COX)-2 expression, inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha/IkappaBbeta degradation, NF-kappaB activation, and the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta, and prostaglandin E2 in BV-2 cells.
Negative_regulation (reduced) of Gene_expression (expression) of COX associated with necrosis and cancer
17) Confidence 0.17 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.99 Pain Relevance 0.20
While NSAIDs could inhibit enzymatic activity of COX-2, they did not inhibit COX-2 gene expression in ESCC cells.
Negative_regulation (inhibit) of Gene_expression (expression) of COX
18) Confidence 0.17 Published 2002 Journal Scand. J. Gastroenterol. Section Body Doc Link 11989839 Disease Relevance 0.12 Pain Relevance 0
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Negative_regulation (reduced) of Gene_expression (overexpression) of COX
19) Confidence 0.17 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
No COX expression was detected in astrocytes.
Negative_regulation (detected) of Gene_expression (expression) of COX in astrocytes
20) Confidence 0.17 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11194936 Disease Relevance 0.95 Pain Relevance 0.27

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