INT64176

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 35
Total Number 39
Disease Relevance 15.10
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
macrophages 4
lung 4
SH-SY5Y 2
HMSM 2
PGE2 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 20 100.00 Very High Very High Very High
cINOD 84 99.92 Very High Very High Very High
Inflammation 275 98.94 Very High Very High Very High
aspirin 32 97.50 Very High Very High Very High
antagonist 97 97.24 Very High Very High Very High
cytokine 36 95.84 Very High Very High Very High
Abeta 2 93.04 High High
Pain 9 84.00 Quite High
Paracetamol 12 83.88 Quite High
agonist 19 72.92 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 47 99.92 Very High Very High Very High
Carcinoma 8 99.56 Very High Very High Very High
Reprotox - General 1 3 99.48 Very High Very High Very High
Cancer 120 99.16 Very High Very High Very High
INFLAMMATION 336 98.94 Very High Very High Very High
Skin Cancer 24 98.80 Very High Very High Very High
Adenocarcinoma 19 98.64 Very High Very High Very High
Neuroblastoma 160 98.40 Very High Very High Very High
Prostate Cancer 4 96.60 Very High Very High Very High
Breast Cancer 7 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation.
Transcription (transcription) of COX
1) Confidence 0.41 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9187256 Disease Relevance 0.33 Pain Relevance 0.36
These results demonstrate that NSAID's action in human macrophages is not directed towards the transcription or translation of the COX genes but only to the enzymatic activity of the proteins.
Transcription (transcription) of COX in macrophages associated with cinod
2) Confidence 0.30 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.14 Pain Relevance 0.36
The effects of AA are independent from induction of COX mRNA expression, or of de novo protein synthesis.
Transcription (expression) of COX
3) Confidence 0.26 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.65 Pain Relevance 0.14
Here we show that interleukin (IL)-1beta induces COX-2 mRNA and protein synthesis and the release of PGE(2) in the human neuroblastoma cell line SK-N-SH.
Transcription (synthesis) of COX in SK-N-SH associated with neuroblastoma
4) Confidence 0.25 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.52 Pain Relevance 0.13
Our data suggest that IL-1beta-induced COX-2 expression in SK-N-SH cells is regulated by different mechanisms, presumably involving mRNA transcription and mRNA stability.
Transcription (transcription) of COX in SK-N-SH
5) Confidence 0.25 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.44 Pain Relevance 0.11
Increased levels of COX-2 mRNA were found in four of five cell lines, and only in PANC-1 cells was the low level of transcript comparable to that in the normal pancreas.
Transcription (levels) of COX in pancreas
6) Confidence 0.25 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10485483 Disease Relevance 0.72 Pain Relevance 0.14
Cyclooxygenase (COX)-2 mRNA and protein expression were found to be frequently elevated in human pancreatic adenocarcinomas and cell lines derived from such tumors.
Transcription (expression) of COX associated with adenocarcinoma and cancer
7) Confidence 0.25 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10485483 Disease Relevance 0.57 Pain Relevance 0.07
COX-2 mRNA production.
Transcription (production) of COX
8) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.23 Pain Relevance 0
We have determined (i) the immuno-localization of all three PGES enzymes in lower segment pregnant human myometrium, (ii) the expression of PGES and COX-2 mRNA expression at term and preterm gestation with and without labour and (iii) the effect of interleukin (IL)-1beta on COX-2 and PGES mRNA and protein expression in human myometrial smooth muscle (HMSM) cell cultures.
Transcription (expression) of COX in HMSM
9) Confidence 0.23 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.07 Pain Relevance 0.18
COX-1 was the most abundant COX mRNA before exercise and remained unchanged (P > 0.05) following exercise.
Transcription (abundant) of COX
10) Confidence 0.22 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17322116 Disease Relevance 0 Pain Relevance 0.27
Here, we show that EGCG inhibits COX-2 without affecting COX-1 expression at both the mRNA and protein levels, in androgen-sensitive LNCaP and androgen-insensitive PC-3 human prostate carcinoma cells.
Transcription (mRNA) of COX in PC-3 associated with prostate cancer
11) Confidence 0.22 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15455372 Disease Relevance 0.65 Pain Relevance 0.07
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Transcription (expression) of COX in macrophages associated with cinod
12) Confidence 0.22 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.39
Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.
Transcription (expression) of COX in Macrophages associated with aspirin
13) Confidence 0.22 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.15 Pain Relevance 0.38
In this study we evaluated the effect of several NSAIDs on COX-1 and COX-2 mRNA, protein expression and PGE2 production in PMA-differentiated THP-1 and U937 human macrophages stimulated with LPS.
Transcription (expression) of COX in macrophages associated with cinod
14) Confidence 0.22 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.39
Cox-2 mRNA steady-state levels were high in well-differentiated adenocarcinoma samples, but low in poorly differentiated adenocarcinoma, squamous cell carcinoma, and small cell lung cancer, as detected by Northern blot analysis.
Transcription (levels) of Cox in lung associated with adenocarcinoma, lung cancer and skin cancer
15) Confidence 0.21 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9823297 Disease Relevance 1.35 Pain Relevance 0.17
We have now studied the expression of Cox-2 mRNA and protein in human lung adenocarcinoma, squamous cell carcinoma, and small cell lung cancer.
Transcription (expression) of Cox in lung associated with adenocarcinoma, lung cancer and skin cancer
16) Confidence 0.21 Published 1998 Journal Cancer Res. Section Abstract Doc Link 9823297 Disease Relevance 1.16 Pain Relevance 0.18
In contrast, Cox-1 mRNA levels were not elevated in the carcinoma.
Transcription (levels) of Cox associated with carcinoma
17) Confidence 0.21 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9102213 Disease Relevance 0.94 Pain Relevance 0.23
However, Cox-2 mRNA was not expressed in mucinous ovarian carcinoma samples as detected by Northern blot hybridization.
Neg (not) Transcription (expressed) of Cox associated with reprotox - general 1
18) Confidence 0.21 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9102213 Disease Relevance 0.94 Pain Relevance 0.22
We have determined (i) the immuno-localization of all three PGES enzymes in lower segment pregnant human myometrium, (ii) the expression of PGES and COX-2 mRNA expression at term and preterm gestation with and without labour and (iii) the effect of interleukin (IL)-1beta on COX-2 and PGES mRNA and protein expression in human myometrial smooth muscle (HMSM) cell cultures.
Transcription (expression) of COX in HMSM
19) Confidence 0.17 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.08 Pain Relevance 0.19
In addition, samples of OA and RA synovial tissue were analyzed for levels of COX-1 and COX-2 messenger RNA (mRNA) using reverse transcriptase-polymerase chain reaction.
Spec (analyzed) Transcription (levels) of COX
20) Confidence 0.17 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9433877 Disease Relevance 0.50 Pain Relevance 0

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