INT64184

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.81
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
lining cell 2
neutrophils 2
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 118 85.12 High High
cytokine 26 63.44 Quite High
antagonist 12 50.00 Quite Low
spinal inflammation 3 50.00 Quite Low
metalloproteinase 1 50.00 Quite Low
Potency 10 49.12 Quite Low
anesthesia 3 34.64 Quite Low
Inflammation 66 9.60 Low Low
Osteoarthritis 20 5.00 Very Low Very Low Very Low
Bioavailability 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 12 99.86 Very High Very High Very High
Respiratory Syncytial Virus 232 99.20 Very High Very High Very High
Osteoporosis 40 97.08 Very High Very High Very High
Nephrotoxicity 5 92.96 High High
Rheumatoid Arthritis 118 85.12 High High
Hypercalcemia 34 74.92 Quite High
Body Weight 3 56.08 Quite High
Low Back Pain 2 50.00 Quite Low
INFLAMMATION 65 49.80 Quite Low
Rheumatic Diseases 1 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With regard to the temporal analysis of the osseointegration process, it was observed that after 14 postoperative days, there was a decrease in the expression of RANK proteins in osteoblasts lineage cells, and at 14 and 21 postoperative days, it was observed the RANK immunolabeling in osteocytes and bone-lining cell.
Negative_regulation (decrease) of Gene_expression (expression) of RANK in lining cell
1) Confidence 0.57 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913635 Disease Relevance 0.15 Pain Relevance 0.04
At 21 postoperative days, RANK expression was reduced when compared with previous periods and the morphology of the cells differed from the aspect observed at 7 postoperative days (Figure 2(c)).
Negative_regulation (reduced) of Gene_expression (expression) of RANK
2) Confidence 0.57 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913635 Disease Relevance 0.19 Pain Relevance 0
The absence of OPG or RANK expression in healthy neutrophils was confirmed by qualitative PCR using an increasing number of cycles as indicated in Table 1 (data not shown).
Negative_regulation (absence) of Gene_expression (expression) of RANK in neutrophils
3) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.30 Pain Relevance 0.15
In these cells, a decrease in the expression of OPG and RANK was observed when incubated in CM and an increase was observed when incubated in SM.
Negative_regulation (decrease) of Gene_expression (expression) of RANK
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0 Pain Relevance 0.03
Clear expression of RANK ligand was only detected in one patient with AS.
Negative_regulation (detected) of Gene_expression (expression) of RANK
5) Confidence 0.16 Published 2009 Journal Ann. Rheum. Dis. Section Body Doc Link 18678577 Disease Relevance 0 Pain Relevance 0
The expression of RANK was significantly reduced in the presence of RSV analogues at the concentration range that inhibited OC differentiation (100 nM to 1 ?
Negative_regulation (reduced) of Gene_expression (expression) of RANK associated with respiratory syncytial virus
6) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.66 Pain Relevance 0
Treatment with RSV [10] and RSV analogues induced the expression of c-fms while downregulating the expression of RANK, thus retaining the monocytic phenotype of OC progenitors.
Negative_regulation (downregulating) of Gene_expression (expression) of RANK associated with fibromyalgia and respiratory syncytial virus
7) Confidence 0.09 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 1.21 Pain Relevance 0
Several recent reports have shown that quinacrine, besides being a potent inhibitor of PLA2, suppresses the generation of ODFR.
Negative_regulation (suppresses) of Gene_expression (generation) of ODFR
8) Confidence 0.06 Published 1996 Journal Transplantation Section Abstract Doc Link 8781605 Disease Relevance 0.31 Pain Relevance 0

General Comments

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