INT64185

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 5
Speculated 6
Reported most in Body
Documents 131
Total Number 140
Disease Relevance 75.15
Pain Relevance 24.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
neutrophils 51
osteoblasts 10
osteoclasts 8
T lymphocytes 6
dendritic cells 5
TNFRSF11A (Homo sapiens)
TNFRSF11A - R265H (1)
Pain Link Frequency Relevance Heat
Inflammation 2672 100.00 Very High Very High Very High
mu opioid receptor 14 100.00 Very High Very High Very High
rheumatoid arthritis 4967 99.98 Very High Very High Very High
Arthritis 343 99.92 Very High Very High Very High
Osteoarthritis 1043 99.62 Very High Very High Very High
COX2 2 99.42 Very High Very High Very High
cytokine 1060 99.12 Very High Very High Very High
Morphine 3 98.40 Very High Very High Very High
aspirin 12 95.92 Very High Very High Very High
Analgesic 3 91.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2591 100.00 Very High Very High Very High
Rheumatoid Arthritis 4967 99.98 Very High Very High Very High
Osteoporosis 900 99.98 Very High Very High Very High
Cancer 1146 99.96 Very High Very High Very High
Arthritis 261 99.92 Very High Very High Very High
Pancreatic Cancer 21 99.92 Very High Very High Very High
Giant Cell Tumors 57 99.84 Very High Very High Very High
Skin Cancer 14 99.76 Very High Very High Very High
Osteoarthritis 1041 99.62 Very High Very High Very High
Necrosis 779 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of RANK-L, OPG, and RANK proteins by SF neutrophils from patients with RA
Gene_expression (Expression) of RANK in neutrophils associated with rheumatoid arthritis
1) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.46 Pain Relevance 0.23
Expression of RANK-L, OPG, and RANK proteins by SF neutrophils from patients with RA
Gene_expression (Expression) of RANK in neutrophils associated with rheumatoid arthritis
2) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.46 Pain Relevance 0.23
In these cells, a decrease in the expression of OPG and RANK was observed when incubated in CM and an increase was observed when incubated in SM.
Gene_expression (expression) of RANK
3) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0 Pain Relevance 0.03
The findings that inflammatory neutrophils spontaneously express RANK (Figures 1 and 2d) and that healthy blood neutrophils express RANK only after stimulation raise the possibility that neutrophils are involved in bone remodeling.
Gene_expression (express) of RANK in neutrophils associated with inflammation
4) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.57 Pain Relevance 0.28
Finally, the expression of RANK protein was also determined by Western blot analysis in freshly isolated SF neutrophils of four patients with RA.
Gene_expression (expression) of RANK protein in neutrophils associated with rheumatoid arthritis
5) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.72 Pain Relevance 0.36
The expression of RANK by neutrophils was detectable from day 2 to day 3 (results observed in two donors out of nine healthy subjects studied).
Gene_expression (expression) of RANK in neutrophils
6) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.11 Pain Relevance 0.10
SF from patients with RA activates the expression of RANK-L, OPG, and RANK in normal blood neutrophils
Gene_expression (expression) of RANK in neutrophils associated with rheumatoid arthritis
7) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.40 Pain Relevance 0.25
The production of RANK protein by inflammatory neutrophils could be related to a pathophysiological role.
Gene_expression (production) of RANK protein in neutrophils associated with inflammation
8) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.68 Pain Relevance 0.39
In contrast, PBMLs expressed OPG and RANK from day 0 (Figure 1b) to day 3 (data not shown).
Gene_expression (expressed) of RANK
9) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0 Pain Relevance 0.03
are implicated in inducing RANK expression.
Gene_expression (expression) of RANK
10) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.67 Pain Relevance 0.36
However, freshly isolated SF neutrophils of patients with RA, as well as healthy blood neutrophils, expressed RANK-L protein on their plasma membrane, as evaluated by cytofluorometry (Figure 2b).
Gene_expression (expressed) of RANK in blood associated with rheumatoid arthritis
11) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.62 Pain Relevance 0.31
The cellular sources of RANK-L in these rheumatoid bone destruction sites were not all identified with no mention of neutrophils [33].
Gene_expression (sources) of RANK in neutrophils
12) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.78 Pain Relevance 0.28
Having established that inflammatory cytokines can stimulate healthy blood neutrophils to express OPG and RANK (Figure 3) and that SF neutrophils from patients with RA spontaneously expressed RANK-L, OPG, and RANK proteins (Figure 2), we next investigated the effect of SF on the expression of these genes by incubating healthy human blood neutrophils in the presence of SF from patients with RA (Figure 4).
Gene_expression (expressed) of RANK in neutrophils associated with inflammation, rheumatoid arthritis and cytokine
13) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.50 Pain Relevance 0.30
T lymphocytes, for instance, promote bone loss in inflammatory arthritis by expressing RANK-L that directly binds and activates osteoclasts [24].
Gene_expression (expressing) of RANK in osteoclasts associated with inflammation and arthritis
14) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.79 Pain Relevance 0.24
In the presence of certain stimuli, cells can express both RANK-L and RANK, an observation reported in T lymphocytes [15,23].
Gene_expression (express) of RANK in T lymphocytes
15) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.05 Pain Relevance 0.19
alone expressed RANK-L but not OPG.
Gene_expression (expressed) of RANK
16) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.26 Pain Relevance 0.18
The fact that SF and blood neutrophils express RANK-L as membrane materials and that neutrophils incubated in vitro for up to 4 days generated no soluble RANK-L (Figure 2a) allow us to consider neutrophils as a new cell type that generates RANK-L without any release in the extracellular milieu.
Gene_expression (express) of RANK in neutrophils
17) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.53 Pain Relevance 0.26
In contrast, PBMLs cultured under similar conditions secreted RANK-L and OPG in the supernatants (data not shown), confirming that neutrophils and PBMLs expressed RANK-L and OPG differently.


Gene_expression (expressed) of RANK in neutrophils
18) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.32 Pain Relevance 0.20
From that point of view, neutrophils are different from other cell types such as osteoblasts, fibroblasts, or T lymphocytes, which produce RANK-L and release soluble RANK-L after stimulation [17,24,30,31].
Gene_expression (produce) of RANK in T lymphocytes
19) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.58 Pain Relevance 0.25
Incubation of healthy blood neutrophils in CM or SM conditions for up to 3 days did not modify the membrane expression of RANK-L as evaluated by cytofluorometry and did not stimulate the release of detectable amounts of OPG in neutrophil supernatants as measured by EIA (data not shown).
Gene_expression (expression) of RANK in neutrophil
20) Confidence 0.76 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox