INT64186

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.19
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
neutrophils 16
osteoblasts 3
osteoclast 2
stromal cells 1
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 638 99.98 Very High Very High Very High
cytokine 132 98.40 Very High Very High Very High
Inflammation 341 98.12 Very High Very High Very High
Osteoarthritis 110 91.36 High High
Arthritis 44 75.72 Quite High
antagonist 13 56.20 Quite High
anesthesia 1 25.00 Low Low
psoriasis 11 5.32 Low Low
cINOD 11 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 105 100.00 Very High Very High Very High
Rheumatoid Arthritis 638 99.98 Very High Very High Very High
Nephrotoxicity 5 99.20 Very High Very High Very High
Hypercalcemia 42 98.74 Very High Very High Very High
INFLAMMATION 330 98.12 Very High Very High Very High
Osteoarthritis 110 91.36 High High
Apoptosis 104 84.44 Quite High
Necrosis 99 80.16 Quite High
Cancer 99 79.80 Quite High
Arthritis 33 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are implicated in inducing RANK expression.
Positive_regulation (inducing) of Gene_expression (expression) of RANK
1) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.68 Pain Relevance 0.36
SF from patients with RA activates the expression of RANK-L, OPG, and RANK in normal blood neutrophils
Positive_regulation (activates) of Gene_expression (expression) of RANK in neutrophils associated with rheumatoid arthritis
2) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.40 Pain Relevance 0.25
The positive control was COS-7 cells transiently transfected (Fugene 6 transfection reagent; Roche Diagnostics, Indianapolis, IN, USA) with human RANK cDNA.
Positive_regulation (transfected) of Gene_expression (transfected) of RANK
3) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.10 Pain Relevance 0.05
However, compared with the cytokine combination present in SM, the SFs from patients with RA are more efficient at activating neutrophils to express RANK, indicating that factors other than GM-CSF+IL-4+TNF-?
Positive_regulation (activating) of Gene_expression (express) of RANK in neutrophils associated with rheumatoid arthritis and cytokine
4) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.56 Pain Relevance 0.33
SF from patients with RA activates the expression of RANK-L, OPG, and RANK in normal blood neutrophils
Positive_regulation (neutrophils) of Gene_expression (expression) of RANK in neutrophils associated with rheumatoid arthritis
5) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.41 Pain Relevance 0.25
Bone resorption is dependent upon osteoblast-osteoclast interactions that are mediated through the osteoblastic expression of a membrane form of RANK-L.
Positive_regulation (mediated) of Gene_expression (expression) of RANK in osteoclast associated with osteoporosis and hypercalcemia
6) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.30 Pain Relevance 0.23
SF from patients with RA activates the expression of RANK-L, OPG, and RANK in normal blood neutrophils
Positive_regulation (neutrophils) of Gene_expression (expression) of RANK in neutrophils associated with rheumatoid arthritis
7) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.41 Pain Relevance 0.25
SF from patients with RA activates the expression of RANK-L, OPG, and RANK in normal blood neutrophils
Positive_regulation (activates) of Gene_expression (expression) of RANK in neutrophils associated with rheumatoid arthritis
8) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.40 Pain Relevance 0.25
Moreover, we demonstrate that the expression of genes of the RANK/RANK-L pathway could be induced by certain stimuli in neutrophils in vitro.
Positive_regulation (induced) of Gene_expression (expression) of RANK in neutrophils
9) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.77 Pain Relevance 0.34
Remarkably, healthy human blood neutrophils can be induced to express RANK and OPG in response to different stimuli such as IL-4+TNF-?
Positive_regulation (induced) of Gene_expression (express) of RANK in neutrophils
10) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.55 Pain Relevance 0.28
The findings that inflammatory neutrophils spontaneously express RANK (Figures 1 and 2d) and that healthy blood neutrophils express RANK only after stimulation raise the possibility that neutrophils are involved in bone remodeling.
Positive_regulation (after) of Gene_expression (express) of RANK in neutrophils associated with inflammation
11) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.48 Pain Relevance 0.31
B ligand (RANK-L) likely plays a key role, and the expression of RANK-L is significantly increased in osteoblasts and stromal cells when stimulated by glucocorticoids.11 Macrophage colony-stimulating factor levels are also increased with exposure to glucocorticoids through increased nuclear transcription of the macrophage colony-stimulating factor gene.11 RANK-L and macrophage colony-stimulating factor both play pivotal roles in inducing osteoclastogenesis and decreasing osteoclast apoptosis, thereby leading to increased bone resorption (Figure 1).
Positive_regulation (increased) of Gene_expression (expression) of RANK-L in osteoblasts associated with hypercalcemia and apoptosis
12) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.44 Pain Relevance 0
Increased generation of oxygen derived free radicals (ODFR) and enhanced activity of phospholipase A2 (PLA2) have been observed in experimental animals following treatment with CsA.
Positive_regulation (Increased) of Gene_expression (generation) of ODFR
13) Confidence 0.06 Published 1996 Journal Transplantation Section Abstract Doc Link 8781605 Disease Relevance 0.25 Pain Relevance 0
B ligand (RANK-L) likely plays a key role, and the expression of RANK-L is significantly increased in osteoblasts and stromal cells when stimulated by glucocorticoids.11 Macrophage colony-stimulating factor levels are also increased with exposure to glucocorticoids through increased nuclear transcription of the macrophage colony-stimulating factor gene.11 RANK-L and macrophage colony-stimulating factor both play pivotal roles in inducing osteoclastogenesis and decreasing osteoclast apoptosis, thereby leading to increased bone resorption (Figure 1).
Positive_regulation (increased) of in stromal cells Gene_expression (expression) of RANK-L in osteoblasts associated with hypercalcemia and apoptosis
14) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.44 Pain Relevance 0

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