INT64192

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Context Info
Confidence 0.19
First Reported 1996
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.87
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gtf2a2) transcription factor binding (Gtf2a2)
Anatomy Link Frequency
tail 1
Gtf2a2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 26 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
tolerance 16 100.00 Very High Very High Very High
analgesia 3 100.00 Very High Very High Very High
nMDA receptor 3 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
antinociception 2 100.00 Very High Very High Very High
tail-flick 5 99.60 Very High Very High Very High
opioid receptor 26 99.52 Very High Very High Very High
Antihyperalgesic 8 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Salmonella Infection 4 95.28 Very High Very High Very High
Ataxia 8 94.88 High High
Hyperalgesia 3 93.68 High High
Infection 2 90.36 High High
INFLAMMATION 2 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of N-methyl-D-aspartate receptor antagonists on the analgesia and tolerance to D-Ala2, Glu4 deltorphin II, a delta 2-opioid receptor agonist in mice.
Regulation (Effects) of deltorphin II associated with antagonist, nmda receptor, agonist, tolerance, opioid receptor and analgesia
1) Confidence 0.19 Published 1996 Journal Brain Res. Section Title Doc Link 8782863 Disease Relevance 0 Pain Relevance 1.11
In contrast to the antihyperalgesic responses, tolerance to the motoric effect of deltorphin II was evident in mice previously exposed to multiple intrathecal agonist injections, but not multiple saline administrations.
Regulation (effect) of deltorphin II associated with antihyperalgesic, agonist, tolerance and intrathecal
2) Confidence 0.09 Published 2009 Journal Neuroscience Section Abstract Doc Link 19328839 Disease Relevance 0.32 Pain Relevance 1.51
In both rodent species, the effect of deltorphin II was not modified by a single prior administration of deltorphin II, suggesting an absence of acute tolerance in this paradigm.
Neg (not) Regulation (modified) of deltorphin II associated with tolerance
3) Confidence 0.09 Published 2009 Journal Neuroscience Section Abstract Doc Link 19328839 Disease Relevance 0.30 Pain Relevance 1.00
Intraperitoneal or ICV injections of M3G did not produce any effect on the tail flick latency nor did it affect the antinociception-induced by morphine, U-50,488H, DPDPE, or deltorphin II.
Neg (nor) Regulation (affect) of deltorphin II in tail associated with antinociception, tail-flick and morphine
4) Confidence 0.03 Published 1996 Journal Peptides Section Abstract Doc Link 8971939 Disease Relevance 0 Pain Relevance 1.64
The present study compared morphine pellets to morphine pumps and also examined the differential effects of morphine versus U50,488H (kappa agonist), deltorphin II (delta2 agonist), and (D-Pen2, D-Pen5)-enkephalin (DPDPE, delta1 agonist), administered via Alzet minipumps, on oral Salmonella infection and on gastrointestinal transit.
Spec (examined) Regulation (effects) of deltorphin II associated with salmonella infection, agonist, enkephalin and morphine
5) Confidence 0.01 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16513108 Disease Relevance 0.26 Pain Relevance 1.10

General Comments

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