INT64193

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 2.98
Pain Relevance 10.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
synapse 2
eye 1
dentate gyrus 1
brain 1
hippocampus 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 508 100.00 Very High Very High Very High
Glutamate 238 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
ketamine 5 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
depression 176 99.96 Very High Very High Very High
antagonist 78 99.96 Very High Very High Very High
agonist 50 99.88 Very High Very High Very High
Morphine 33 99.64 Very High Very High Very High
Hippocampus 304 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 354 100.00 Very High Very High Very High
Depression 176 99.96 Very High Very High Very High
Pain 12 96.24 Very High Very High Very High
Targeted Disruption 113 91.80 High High
Congenital Anomalies 22 89.12 High High
Ataxia 15 83.32 Quite High
Adhesions 8 82.12 Quite High
Nervous System Malformation 9 79.68 Quite High
Sprains And Strains 34 78.56 Quite High
Cognitive Disorder 102 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our results show that there is an age-dependent regulation of NMDAR subunits NR1 and NR2A, but not NR2B, in NT-3 +/- mice.
Regulation (regulation) of NR2A
1) Confidence 0.54 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.08 Pain Relevance 0.24
Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems.
Regulation (affect) of N-methyl-D-aspartate receptor associated with nmda receptor, agonist, tolerance and morphine
2) Confidence 0.51 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316854 Disease Relevance 0 Pain Relevance 1.30
Effects of N-methyl-D-aspartate receptor antagonists on the analgesia and tolerance to D-Ala2, Glu4 deltorphin II, a delta 2-opioid receptor agonist in mice.
Regulation (Effects) of N-methyl-D-aspartate receptor associated with antagonist, nmda receptor, agonist, tolerance, opioid receptor and analgesia
3) Confidence 0.39 Published 1996 Journal Brain Res. Section Title Doc Link 8782863 Disease Relevance 0 Pain Relevance 1.05
The present study was designed to clarify the role of the NR1, NR2A and NR2B subunits of N-methyl-D-aspartate receptors in the development of morphine-induced place preference using specific antibodies to N-methyl-D-aspartate receptor subunits in the mouse.
Regulation (role) of NR2A associated with nmda receptor and morphine
4) Confidence 0.39 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113309 Disease Relevance 0.13 Pain Relevance 0.39
In the ACC, NMDA receptor-dependent plasticity including LTP and long-term depression, depend on both NR2B and NR2A subunit-containing NMDA receptors [13,14].
Regulation (depend) of NR2A associated with depression, nmda receptor, long-term potentiation and anterior cingulate cortex
5) Confidence 0.33 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.51 Pain Relevance 0.96
The loss of synaptic NR2A-containing receptors in the Neto1-null mice implies that the molecular events regulating the delivery or stability of NR2A-NMDARs at the synapse differ from those regulating NR2B-NMDARs.
Regulation (regulating) of NR2A in synapse
6) Confidence 0.33 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Regulation (Effects) of N-methyl-D-aspartate receptor associated with antinociception, nociceptor, antagonist, nmda receptor, methadone and morphine
7) Confidence 0.32 Published 2005 Journal J Pain Section Title Doc Link 15993820 Disease Relevance 0 Pain Relevance 2.12
F344XBN rats show similar age-related declines in protein expression of the GluN2A and GluN2B subunits in the hippocampus as a whole, but the GluN2A subunit is not affected by aging within the dentate gyrus alone (Newton et al., 2007).
Neg (not) Regulation (affected) of GluN2A subunit in dentate gyrus associated with aging and hippocampus
8) Confidence 0.29 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.66 Pain Relevance 0.30
Differences in motifs within the extracellular or cytoplasmic domains may thus be responsible for the differential effect on synaptic NR2A NMDARs in the Neto1-null mice.
Regulation (effect) of NR2A
9) Confidence 0.29 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
m is modified via changing the NR2A/B ratio, and a change in ?
Regulation (changing) of NR2A
10) Confidence 0.25 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.09 Pain Relevance 0.22
m is permissive for the potentiation of the open eye, the time course of the changes in the NR2A/B ratio (and therefore ?
Regulation (changes) of NR2A in eye
11) Confidence 0.25 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.09 Pain Relevance 0.22
Synaptic neurotransmission, one of the significantly altered GO biological processes in Glud1 mice (Table 1), contained two of the most up-regulated genes in Glud1 mice, those for the two Glu-activated synaptic receptors, the N-methyl-d-aspartate (NMDA) Receptor Subunits 2A and 2B (Grin2A and Grin2B).
Regulation (regulated) of Grin2A associated with glutamate
12) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.42 Pain Relevance 0.29
The expression of NR1 and the composition of the NR2 subunits are developmentally regulated.
Regulation (regulated) of NR2
13) Confidence 0.21 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.56
Interestingly, NR2B over-expressing animals are not more susceptible to plasticity (Philpot et al. 2001), possibly because modulating NR2B transcript did not affect the NR2A/2B ratio in this study.
Neg (not) Spec (possibly) Regulation (affect) of NR2A
14) Confidence 0.20 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.07 Pain Relevance 0.21
and 1.5 fold in Tg20; NR2A and NR2B subunits were inversely regulated in Tg20 and Prnp ?
Regulation (regulated) of NR2A
15) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2763346 Disease Relevance 0 Pain Relevance 0.09
We also examined the effects of ketamine, a noncompetitive N-mthyl-D-aspartate receptor (NR) antagonist, on morphine-, F9202- and F9204- induced CPP and phosphorylation of CREB in hippocampus.
Spec (examined) Regulation (effects) of N-mthyl-D-aspartate receptor in hippocampus associated with ketamine, antagonist, hippocampus and morphine
16) Confidence 0.15 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.87
Although there is less of an affect of aging on the GluN2A subunit than the other subunits, the expression of the GluN2A subunit in aged mice does appear to influence spatial learning.
Regulation (affect) of GluN2A subunit associated with aging
17) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.39 Pain Relevance 0.10
An age-related decline in the GluN2B subunit within the synapse, with little or no change in the GluN2A (Magnusson, 2000; Magnusson et al., 2002) and GluN1 subunits could lead to a synaptic population of NMDA receptors that have decreased agonist affinity, faster kinetics, and reduced LTP associated with binding of calcium calmodulin kinase II (Kutsuwada et al., 1992; Monyer et al., 1992; Yamazaki et al., 1992; Ishii et al., 1993; Barria and Malinow, 2005) than in the young adult.
Neg (little) Regulation (change) of GluN2A in synapse associated with nmda receptor, agonist and long-term potentiation
18) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.05 Pain Relevance 0.36
Significant changes in protein levels of NMDA receptor subunits NR1 and NR2A, and NMDA receptor interacting proteins PSD-95 and SAP97 were not detected.
Regulation (changes) of NR2A associated with nmda receptor
19) Confidence 0.12 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.39
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Neg (no) Regulation (effect) of NR2A in brain
20) Confidence 0.09 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.17 Pain Relevance 0.05

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