INT64202

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 15
Speculated 20
Reported most in Abstract
Documents 643
Total Number 663
Disease Relevance 249.66
Pain Relevance 397.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 60
DRG 22
nerve 21
nociceptors 20
sensory neurons 14
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 11081 100.00 Very High Very High Very High
dorsal root ganglion 4118 100.00 Very High Very High Very High
Pain 3803 100.00 Very High Very High Very High
Inflammation 2722 100.00 Very High Very High Very High
agonist 2095 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1873 100.00 Very High Very High Very High
Nerve growth factor 1234 100.00 Very High Very High Very High
substance P 966 100.00 Very High Very High Very High
TRP channel 927 100.00 Very High Very High Very High
c fibre 852 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5545 100.00 Very High Very High Very High
Pain 3808 100.00 Very High Very High Very High
INFLAMMATION 2416 100.00 Very High Very High Very High
Hyperalgesia 1725 100.00 Very High Very High Very High
Nociception 1712 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 407 100.00 Very High Very High Very High
Anxiety Disorder 143 100.00 Very High Very High Very High
Diabetes Mellitus 238 99.98 Very High Very High Very High
Pancreatitis 10 99.98 Very High Very High Very High
Colitis 9 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage.
Positive_regulation (upregulated) of Vanilloid receptor 1 in nerve associated with nervous system injury and inflammation
1) Confidence 0.70 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 16420034 Disease Relevance 0.45 Pain Relevance 0.50
Tests on the activation of rat TRPV1 were also performed.
Positive_regulation (activation) of TRPV1
2) Confidence 0.70 Published 2005 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 16244447 Disease Relevance 0 Pain Relevance 0.18
Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1.
Positive_regulation (activation) of TRPV1 associated with pain
3) Confidence 0.70 Published 2005 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 16244447 Disease Relevance 0 Pain Relevance 0.23
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.
Positive_regulation (activated) of VR1 in primary sensory neurons associated with qutenza
4) Confidence 0.70 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524156 Disease Relevance 0.08 Pain Relevance 0.37
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.
Positive_regulation (activated) of vanilloid receptor-1 in primary sensory neurons associated with qutenza
5) Confidence 0.70 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524156 Disease Relevance 0.08 Pain Relevance 0.37
Blockade of TRPV1 activation by selective antagonists is under investigation in an attempt to identify novel agents for pain treatment.
Positive_regulation (activation) of TRPV1 associated with pain and antagonist
6) Confidence 0.70 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20307063 Disease Relevance 0.15 Pain Relevance 0.51
Nicotine did not alter the threshold temperature (approximately 41 degrees C) of heat-activated currents in TG neurons that were attributed to arise from the activation of TRPV1 receptors.
Positive_regulation (activation) of TRPV1 in neurons associated with trigeminal ganglion and nicotine
7) Confidence 0.70 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14657192 Disease Relevance 0.53 Pain Relevance 1.11
Although blockade of capsaicin-induced VR1 activation has been demonstrated in vitro and in vivo with the antagonist capsazepine, efficacy in rat models of chronic pain has not been observed with this compound.
Positive_regulation (activation) of VR1 associated with qutenza, lasting pain and antagonist
8) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.10 Pain Relevance 0.66
Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors.
Positive_regulation (activation) of vanilloid receptor 1 in nociceptors associated with qutenza and nociceptor
9) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.08 Pain Relevance 0.62
Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors.
Positive_regulation (activation) of VR1 in nociceptors associated with qutenza and nociceptor
10) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.08 Pain Relevance 0.62
Interestingly however, BCTC also potently inhibits acid-induced activation of rat VR1 (IC50 value of 6.0 nM), whereas capsazepine is inactive.
Positive_regulation (activation) of VR1
11) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.08 Pain Relevance 0.78
Thus, BCTC is a high potency, selective VR1 antagonist that, unlike capsazepine, has potent blocking effects on low pH-induced activation of rat VR1.
Positive_regulation (activation) of VR1 associated with antagonist and potency
12) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.06 Pain Relevance 0.63
Similar to capsazepine, this compound inhibits capsaicin-induced activation of rat VR1 with an IC50 value of 35 nM.
Positive_regulation (activation) of VR1 associated with qutenza
13) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.09 Pain Relevance 0.74
Focal application of heated solutions demonstrated that the normal threshold (approximately 42 degrees C) of TRPV1 activation was reduced in the presence of capsaicin (1 microM) to approximately 30 degrees C.
Positive_regulation (activation) of TRPV1 associated with qutenza
14) Confidence 0.70 Published 2008 Journal Inflamm. Res. Section Abstract Doc Link 18777111 Disease Relevance 0.25 Pain Relevance 0.68
The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures.
Positive_regulation (activated) of vanilloid receptor 1 associated with qutenza
15) Confidence 0.70 Published 2008 Journal Inflamm. Res. Section Abstract Doc Link 18777111 Disease Relevance 0.24 Pain Relevance 0.40
The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures.
Positive_regulation (activated) of TRPV1 associated with qutenza
16) Confidence 0.70 Published 2008 Journal Inflamm. Res. Section Abstract Doc Link 18777111 Disease Relevance 0.24 Pain Relevance 0.40
Thus AIA in the knee joint is not associated with an up-regulation of the TRPV1 receptor in the lumbar DRG neurones.
Positive_regulation (up-regulation) of TRPV1 receptor in knee joint associated with arthritis
17) Confidence 0.70 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135921 Disease Relevance 0.52 Pain Relevance 0.37
The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH.
Positive_regulation (activated) of VR1 in sensory neurons associated with nociception, pain and qutenza
18) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721336 Disease Relevance 0.43 Pain Relevance 0.69
The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH.
Positive_regulation (activated) of vanilloid receptor 1 in sensory neurons associated with nociception, pain and qutenza
19) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721336 Disease Relevance 0.43 Pain Relevance 0.69
Moreover, the effect could occur under modestly acidic conditions (pH 6.5) that did not directly activate TRPV1.
Neg (not) Positive_regulation (activate) of TRPV1
20) Confidence 0.70 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1266034 Disease Relevance 0.15 Pain Relevance 1.13

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