INT64203

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.39
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 2
ovary 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 13 99.98 Very High Very High Very High
antagonist 2 99.04 Very High Very High Very High
allodynia 10 98.92 Very High Very High Very High
Analgesic 5 98.52 Very High Very High Very High
Nerve growth factor 1 98.24 Very High Very High Very High
TRP channel 2 97.84 Very High Very High Very High
Eae 5 97.36 Very High Very High Very High
dorsal root ganglion 7 97.20 Very High Very High Very High
trigeminal ganglion 1 92.04 High High
Kinase C 5 91.52 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 12 98.92 Very High Very High Very High
Injury 6 97.36 Very High Very High Very High
Ganglion Cysts 9 97.20 Very High Very High Very High
Diabetes Mellitus 9 96.52 Very High Very High Very High
Inflammatory Pain 1 84.76 Quite High
Hyperalgesia 2 83.92 Quite High
Pain 3 83.88 Quite High
Syndrome 1 83.12 Quite High
INFLAMMATION 1 82.92 Quite High
Diabetic Neuropathy 3 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin-induced desensitization of VR1 was down-regulated, whereas VR1 re-sensitization was up-regulated in DRG neurons from diabetic rats.
Positive_regulation (induced) of Negative_regulation (desensitization) of VR1 in neurons associated with dorsal root ganglion, qutenza and diabetes mellitus
1) Confidence 0.47 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.68 Pain Relevance 1.22
N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a selective and competitive antagonist of the vanilloid receptor 1 (TRPV1), and resiniferatoxin, which causes desensitization of TRPV1-expressing fibres, suppressed static allodynia but not dynamic allodynia in CCI rats.
Positive_regulation (causes) of Negative_regulation (desensitization) of TRPV1-expressing associated with allodynia, eae and antagonist
2) Confidence 0.47 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18498707 Disease Relevance 1.12 Pain Relevance 0.87
The camphor-induced desensitization of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor.
Positive_regulation (induced) of Negative_regulation (desensitization) of TRPV1 associated with analgesic
3) Confidence 0.46 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192383 Disease Relevance 0 Pain Relevance 0.82
Utilizing Chinese hamster ovary cell lines, we demonstrate that Thr(144) and Thr(370) were dephosphorylated, leading to desensitization of the TRPV1 receptor.
Positive_regulation (leading) of Negative_regulation (desensitization) of TRPV1 receptor in ovary
4) Confidence 0.44 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.41 Pain Relevance 0.47
We conclude that messenger plasticity and vanilloid receptor loss are mediated by distinct mechanisms.
Positive_regulation (mediated) of Negative_regulation (loss) of vanilloid receptor
5) Confidence 0.26 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782884 Disease Relevance 0.18 Pain Relevance 0.29

General Comments

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