INT64208

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 7.51
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 2
T cell 2
SH-SY5Y 1
deltoid 1
Astrocytes 1
Rtl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 35 100.00 Very High Very High Very High
mu opioid receptor 2 99.48 Very High Very High Very High
Morphine 180 99.12 Very High Very High Very High
agonist 14 98.68 Very High Very High Very High
antinociception 12 98.44 Very High Very High Very High
Spinal cord 31 97.72 Very High Very High Very High
Antinociceptive 2 97.28 Very High Very High Very High
substantia gelatinosa 2 96.20 Very High Very High Very High
Opioid 8 95.04 Very High Very High Very High
Enkephalin 6 93.24 High High
Disease Link Frequency Relevance Heat
Microphthalmia 3 100.00 Very High Very High Very High
Cancer 387 99.68 Very High Very High Very High
Influenza Virus Infection 9 98.84 Very High Very High Very High
Alagille Syndrome 92 96.60 Very High Very High Very High
Skin Cancer 211 95.72 Very High Very High Very High
Toxicity 47 94.12 High High
Immunization 20 93.28 High High
Pain 19 92.16 High High
Hepatitis 2 91.28 High High
Vaginal Cancer 1 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar observations have been made in studies of AAV2-MOR expression following intraneural injection [6] and AAV8-GFP following i.t. injection by the atlanto-occipital catheterization method [5].
Gene_expression (expression) of MOR
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2900238 Disease Relevance 0.06 Pain Relevance 0.46
MOR1 and MOR1C stably expressed in human embryonic kidney 293 cells exhibited phosphorylation, internalization, and down-regulation in the presence of the opioid peptide [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO) but not in response to morphine.
Gene_expression (expressed) of MOR1 in embryonic kidney associated with enkephalin, opioid receptor, opioid and morphine
2) Confidence 0.74 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11359768 Disease Relevance 0 Pain Relevance 1.25
- ELISpot for gp100 and Melan A/MART-1
Gene_expression (/) of MART-1
3) Confidence 0.65 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.69 Pain Relevance 0
in ELISpot after 24 hs incubation with autologous DCs pulsed with gp100 or Melan A/MART-1 peptides and, as a control, influenza (flu58–66) peptides.
Gene_expression (pulsed) of MART-1 associated with influenza virus infection
4) Confidence 0.65 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.25 Pain Relevance 0
We analyzed anti-gp100 and Melan A/MART-1 specific CD8+T cell responses induced by DC/Apo-Nec vaccine, by: i) specific HLA/peptide tetramer binding and ii) IFN-?
Gene_expression (responses) of MART-1 in T cell
5) Confidence 0.65 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.64 Pain Relevance 0
Patient #8 had a high frequency of anti-Melan A/MART-1 reactive CD8+T cells before treatment that did not change after vaccination (pre: 0.98%; post: 0.93%); instead, gp100-specific T cells decreased after vaccination (pre: 0.93%; post: 0.25%).
Gene_expression (/) of MART-1 in T cells
6) Confidence 0.65 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.40 Pain Relevance 0
After establishing immunologic activity of the vaccines in mice, groups of three to six HLA-A2-positive patients were enrolled into one of three cohorts in which they received intramuscular injections of the MART-1 plasmid into the right deltoid and the HBsAg plasmid into the left deltoid at doses of 0.1, 0.3, or 1.0 mg on days 1, 43, 85, and 127.
Gene_expression (injections) of MART-1 in deltoid
7) Confidence 0.64 Published 2005 Journal J. Immunother. Section Abstract Doc Link 16000957 Disease Relevance 0.88 Pain Relevance 0.08
Although baseline MART-1-specific lymphoproliferative and ELISPOT responses were evident, no patient manifested increases after injection of the MART-1 plasmid.
Gene_expression (injection) of MART-1
8) Confidence 0.64 Published 2005 Journal J. Immunother. Section Abstract Doc Link 16000957 Disease Relevance 0.86 Pain Relevance 0.09
Astrocytes expressed MOR1 immunoreactivity and morphine's actions were mimicked by the selective mu agonist PL017.
Gene_expression (expressed) of MOR1 in Astrocytes associated with agonist and morphine
9) Confidence 0.54 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782912 Disease Relevance 0.07 Pain Relevance 1.34
The last three patients received the MART-1(27-35) peptide with incomplete Freund's adjuvant mixed with CRL 1005, a block copolymer adjuvant.
Gene_expression (received) of MART-1
10) Confidence 0.53 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537339 Disease Relevance 0.40 Pain Relevance 0
Differential expression of MOR1 and KOR1 showed continuous up-regulation throughout the treatment whereas DOR1 showed down-regulation in initial 3 days followed by subsequently up-regulation during the latter observable period.
Gene_expression (expression) of MOR1
11) Confidence 0.27 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19716174 Disease Relevance 0 Pain Relevance 0.87
To address whether morphine and M6G induce a physiological response in SH-SY5Y cells, we first looked at the expression of the µ opioid receptor family (MOR1; [17], [18], [29], [30]).
Gene_expression (expression) of MOR1 in SH-SY5Y associated with opioid receptor and morphine
12) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0 Pain Relevance 1.09
Therefore, present study was undertaken to investigate whether MERF on systemic (intra-peritoneal, i.p.) route of administration induce any antinociception or not; to scrutinize the effect of 6 days chronic i.p. treatment of MERF on expression of mu (MOR1), delta (DOR1) and kappa (KOR1) opioid receptors; and finally, the antinociceptive effect of two synthetic peptides, MERFamide and (D-Ala(2))-MERFamide was compared with MERF on intracerebroventricular administration in order to understand the role of FMRF moiety in analgesic effect of MERF.
Gene_expression (expression) of MOR1 associated with antinociception, analgesic, opioid receptor, intracerebroventricular and antinociceptive
13) Confidence 0.23 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19716174 Disease Relevance 0 Pain Relevance 0.74
Tumor cells strongly expressed S100 protein, gp100 (HMB-45), and microphthalmia transcription factor, and variably expressed MART1, but not cytokeratins, CD34, or muscle-specific actin.
Gene_expression (expressed) of MART1 in muscle associated with cancer and microphthalmia
14) Confidence 0.14 Published 2002 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 12204064 Disease Relevance 0.59 Pain Relevance 0.08
Tyrosinase was positive in two cases, HMB-45 was positive in one case, and MART-1 was focally positive in one case.
Gene_expression (positive) of MART-1
15) Confidence 0.12 Published 2003 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 12649667 Disease Relevance 0.91 Pain Relevance 0.09
Tumor cells strongly expressed S100 protein, gp100 (HMB-45), and microphthalmia transcription factor, and variably expressed MART1, but not cytokeratins, CD34, or muscle-specific actin.
Neg (not) Gene_expression (expressed) of MART1 in muscle associated with cancer and microphthalmia
16) Confidence 0.11 Published 2002 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 12204064 Disease Relevance 0.57 Pain Relevance 0.08
Preliminary data suggested that there is poor correlation between HLA class I expression on number of HLA-MART-1 complexes suggesting that the simple analysis of HLA complexes may be misleading because it does not take into account the efficiency and individual tumor antigen processing and presentation by cancer cells.
Gene_expression (expression) of MART-1 associated with cancer
17) Confidence 0.05 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.11 Pain Relevance 0
In contrast, MART-1, S100-specific protein, and gp-100 were only expressed by 66%, 33%, and 67% of the analyzed samples, respectively.
Gene_expression (expressed) of MART-1
18) Confidence 0.02 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17325166 Disease Relevance 0.07 Pain Relevance 0

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