INT64215

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 5.27
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
brain 4
PBL 2
shell 1
DA neurons 1
nucleus 1
Drd3 (Rattus norvegicus)
Drd3 - S9G (1)
Pain Link Frequency Relevance Heat
Dopamine 203 100.00 Very High Very High Very High
dopamine receptor 67 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
cerebral cortex 111 99.68 Very High Very High Very High
cocaine 9 99.42 Very High Very High Very High
Nucleus accumbens 41 98.76 Very High Very High Very High
Migraine 10 98.56 Very High Very High Very High
addiction 6 97.12 Very High Very High Very High
substance P 13 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 209 99.80 Very High Very High Very High
Disease 45 99.52 Very High Very High Very High
Headache 10 98.56 Very High Very High Very High
Recurrence 3 97.64 Very High Very High Very High
Diabetes Mellitus 270 97.40 Very High Very High Very High
Drug Dependence 6 97.12 Very High Very High Very High
Dyskinesias 9 91.60 High High
INFLAMMATION 3 91.24 High High
Stress 29 86.52 High High
Parkinson's Disease 2 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured Brain-derived neurotrophic factor (BDNF) and dopamine D3 receptor (Drd3) expressions in rat brain regions that have been involved in drug-conditioning.
Gene_expression (expressions) of dopamine D3 receptor in brain associated with dopamine
1) Confidence 0.78 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671872 Disease Relevance 0.10 Pain Relevance 0.36
We measured Brain-derived neurotrophic factor (BDNF) and dopamine D3 receptor (Drd3) expressions in rat brain regions that have been involved in drug-conditioning.
Gene_expression (expressions) of Drd3 in brain associated with dopamine
2) Confidence 0.78 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671872 Disease Relevance 0.10 Pain Relevance 0.36
A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning.
Gene_expression (expression) of D3 receptor associated with cocaine
3) Confidence 0.78 Published 2005 Journal Neuroreport Section Title Doc Link 15671872 Disease Relevance 0.09 Pain Relevance 0.37
As peripheral blood lymphocytes (PBL) may represent a tool for peripheral detection of neuroreceptors, we compared the expression of dopamine D3 (DRD3) and D4 (DRD4) receptors on PBL in migraine patients and in healthy controls using radioligand binding assay techniques in the presence of antidopamine D2-like receptor antibodies.
Gene_expression (expression) of DRD3 in PBL associated with dopamine and migraine
4) Confidence 0.70 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10817442 Disease Relevance 0.33 Pain Relevance 0.55
As peripheral blood lymphocytes (PBL) may represent a tool for peripheral detection of neuroreceptors, we compared the expression of dopamine D3 (DRD3) and D4 (DRD4) receptors on PBL in migraine patients and in healthy controls using radioligand binding assay techniques in the presence of antidopamine D2-like receptor antibodies.
Gene_expression (expression) of dopamine D3 in PBL associated with dopamine and migraine
5) Confidence 0.70 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10817442 Disease Relevance 0.33 Pain Relevance 0.55
Induction of dopamine D3 receptor gene expression in 6-hydroxydopamine-lesioned rats by repeated administration of levodopa had been suggested to be responsible for behavioural sensitization developing in these animals.
Gene_expression (expression) of D3 receptor associated with dopamine
6) Confidence 0.67 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886351 Disease Relevance 0 Pain Relevance 0.15
Additionally, L-DOPA-induced elevations in striatal pre-proenkephalin-A (PPE-A) (but not PPE-B, phospho[Thr(34)]DARPP-32, D1, and D2 receptor mRNA or D3 receptor levels) were reduced in S33084 treated animals.
Gene_expression (levels) of D3 receptor
7) Confidence 0.52 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19118628 Disease Relevance 0.84 Pain Relevance 0.16
Our results demonstrate that the D3 receptor is co-expressed either with D1 or with D2 receptor, both in the core and shell regions, in a subpopulation of substance P and enkephalin neurons, respectively.
Gene_expression (co-expressed) of D3 receptor in shell associated with enkephalin and substance p
8) Confidence 0.46 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.63
A rat D3 complementary RNA probe labelled with [35S]UTP was used to map the neurons expressing the D3 receptor gene in the rat brain.
Gene_expression (expressing) of D3 receptor in brain
9) Confidence 0.46 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.39
Expression of the D3 dopamine receptor in peptidergic neurons of the nucleus accumbens: comparison with the D1 and D2 dopamine receptors.
Gene_expression (Expression) of D3 dopamine receptor in peptidergic neurons associated with nucleus accumbens, dopamine receptor and enkephalin
10) Confidence 0.46 Published 1996 Journal Neuroscience Section Title Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.56
They also suggest that a significant part of the accumbal neurons only express either D1 or D2, without co-expression with the D3 receptor.
Neg (without) Gene_expression (co-expression) of D3 receptor in neurons
11) Confidence 0.46 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.64
All of these studies showed no association between the Ser9Gly variant of DRD3 gene and OCD.51,73,78


Gene_expression (variant) of DRD3 gene (S9G) associated with anxiety disorder
12) Confidence 0.18 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.89 Pain Relevance 0.34
Genotypic results were determined by restriction endonuclease digestion of polymerase chain reaction products to detect DRD1 and DRD3 alleles and by Genescan analysis after polymerase chain reaction using fluorescently labelled oligonucleotide primers for the DRD5 marker.
Gene_expression (detect) of DRD3
13) Confidence 0.16 Published 2002 Journal Headache Section Body Doc Link 12047334 Disease Relevance 0.06 Pain Relevance 0
It is therefore important to identify the elements that modulate dopaminergic receptor expressions and phosphorylation of CREB and there by its expression in the nucleus.
Gene_expression (expressions) of dopaminergic receptor in nucleus
14) Confidence 0.15 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.46 Pain Relevance 0.36
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.

Gene_expression (expression) of dopaminergic receptor in cerebral cortex associated with inflammation, diabetes mellitus and cerebral cortex
15) Confidence 0.13 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2890658 Disease Relevance 0.61 Pain Relevance 0.37
Therefore, there is a considerable need for new drugs aimed at relieving the motor symptoms associated with PD by directly depressing D3 receptor expression and protecting surviving DA neurons against, or slowing down the progression of, neuronal degeneration in the SN [24, 54].
Gene_expression (expression) of D3 receptor in DA neurons associated with dopamine, substantia nigra and disease
16) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.70 Pain Relevance 0.35
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.

Gene_expression (expression) of dopaminergic receptor in cerebellum associated with inflammation, diabetes mellitus and cerebral cortex
17) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2890658 Disease Relevance 0.61 Pain Relevance 0.37
Antipsychotic drugs did not alter expression of D1R, D2R or D3R receptor mRNAs but elevated neurotensin and proenkephalin expression in both groups of rats; patterns of changes were dependent on the duration of treatment and brain area examined.
Gene_expression (expression) of D3R receptor in brain
18) Confidence 0.03 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.16 Pain Relevance 0.22

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