INT64234

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 41
Total Number 43
Disease Relevance 31.88
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
brain 3
neuronal 2
ECs 2
IEC-6 1
cardiomyocytes 1
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 60 99.60 Very High Very High Very High
agonist 89 98.12 Very High Very High Very High
withdrawal 3 97.38 Very High Very High Very High
methadone 3 97.08 Very High Very High Very High
narcan 1 92.12 High High
anesthesia 20 91.84 High High
depression 3 91.48 High High
antagonist 10 91.40 High High
Opioid 21 90.92 High High
cINOD 27 89.84 High High
Disease Link Frequency Relevance Heat
Apoptosis 1517 100.00 Very High Very High Very High
Death 286 99.62 Very High Very High Very High
Natriuresis 1 99.52 Very High Very High Very High
Repression 11 99.44 Very High Very High Very High
Cancer 730 99.34 Very High Very High Very High
Malignant Neoplastic Disease 39 99.28 Very High Very High Very High
Reprotox - General 1 10 98.64 Very High Very High Very High
Breast Cancer 146 98.36 Very High Very High Very High
Cognitive Disorder 7 98.24 Very High Very High Very High
Wrinkles 5 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the data presented indicates that Hr mediates an anti-apoptotic response involving the regulation of p53 and Bcl2 family members.
Regulation (regulation) of Bcl2 associated with apoptosis
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.50 Pain Relevance 0
Further, these studies exhibited a series of mechanistic information including free radical scavenging ability, anti-endonucleolytic activity, cytochrome P450 2E1 inhibitory activity, anti-necrotic, anti-apoptotic and anti-carcinogenic activities, modulatory effects on antioxidative and apoptotic regulatory genes such as Bcl2, c-myc and p53, which may be responsible for the novel chemoprotective properties exhibited by GSPE.
Regulation (effects) of Bcl2 associated with apoptosis
2) Confidence 0.46 Published 2002 Journal Indian J. Exp. Biol. Section Abstract Doc Link 12587719 Disease Relevance 0.58 Pain Relevance 0.07
Effect of transfection with the bcl-2 gene on chemosensitivity
Regulation (Effect) of bcl-2
3) Confidence 0.45 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0 Pain Relevance 0
Colonic tumors expressed higher levels of Bcl-2 than those from the small intestine and did not show any significant changes in either Bcl-2 or beta-catenin expression after treatment.
Neg (not) Regulation (changes) of Bcl-2 in small intestine associated with cancer
4) Confidence 0.44 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.68 Pain Relevance 0.16
Effect of AS Bcl-2 on expression of apoptosis-related proteins
Regulation (Effect) of Bcl-2 associated with apoptosis
5) Confidence 0.39 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.28 Pain Relevance 0
Effect of AS Bcl-2 on chemosensitivity
Regulation (Effect) of Bcl-2
6) Confidence 0.39 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0 Pain Relevance 0
However, morphine with H37Ra did not alter the levels of Bcl-2 (Fig. 4A) and Bax (Fig. 4B) in the lung from TLR9 KO mice.
Neg (not) Regulation (alter) of Bcl-2 in lung associated with targeted disruption and morphine
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.08 Pain Relevance 0.80
Based on these evidences, we have identified in SCI proapoptotic transcriptional changes, including upregulation of proapoptotic Bax and down regulation of antiapoptotic Bcl-2, by immunohystochemical staining.
Regulation (regulation) of Bcl-2 associated with spinal cord injury and apoptosis
8) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.08 Pain Relevance 0.12
g/ml, pro-apoptotic protein Bax expression was up regulated in a time-dependent manner; the anti-apoptotic protein Bcl-2 was down regulated at 12 h and 24 h time points, but slightly up regulated at 48 h time point.
Regulation (regulated) of Bcl-2 associated with apoptosis
9) Confidence 0.29 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.63 Pain Relevance 0
g/ml, pro-apoptotic protein Bax expression was up regulated in a time-dependent manner; the anti-apoptotic protein Bcl-2 was down regulated at 12 h and 24 h time points, but slightly up regulated at 48 h time point.
Regulation (regulated) of Bcl-2 associated with apoptosis
10) Confidence 0.29 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.61 Pain Relevance 0
Although AS therapy targeting Bcl-2 and Bcl-xL enhances chemosensitivity in breast cancer cells, the effect of blocking Bcl-2 seems superior to that of Bcl-xL.
Regulation (targeting) of Bcl-2 in superior associated with breast cancer
11) Confidence 0.27 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 1.14 Pain Relevance 0
Further studies examining the molecular details involved in the vBcl-2-mediated inhibition of autophagy will expand our understanding of both autophagy and ?
Spec (examining) Regulation (involved) of vBcl-2
12) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.58 Pain Relevance 0
HV68-infected cells, suggesting that HA tagging does not affect vBcl-2 function (Figure 4).
Neg (not) Regulation (affect) of vBcl-2
13) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.06 Pain Relevance 0
Furthermore, all of the vBcl-2 mutants exhibited punctate cytoplasmic staining in the cells, similarly to the WT, except that the ?
Regulation (all) of vBcl-2
14) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.05 Pain Relevance 0
ECs were transduced with either Bcl-2 (EC-Bcl-2) or control vector (EC-VC) by overnight incubation with one-tenth dilution of the viral supernatant in the presence of 6 ?
Regulation (control) of EC-Bcl-2 in ECs
15) Confidence 0.25 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.56 Pain Relevance 0
The mRNAs investigated in this study were Fas, c-fos, c-myc. bcl-2, and p53, and glyceraldehyde-3-phosphate dehydrogenase mRNA was employed as internal control.
Regulation (control) of bcl-2 in internal
16) Confidence 0.24 Published 1996 Journal Oncology Section Abstract Doc Link 8784477 Disease Relevance 0 Pain Relevance 0.09
Mice were treated for 14 days by repeated daily bolus injections of 5 mg/kg AS Bcl-2, synthetic CpG AS Bcl-2, or saline control.
Regulation (control) of Bcl-2
17) Confidence 0.23 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.38 Pain Relevance 0
Therefore, in the present study, we have identified pro-apoptotic transcriptional changes, including up-regulation of pro-apoptotic Bax and down-regulation of anti-apoptotic Bcl-2, using western blot assay and by immunohistochemical staining.
Regulation (regulation) of Bcl-2 associated with apoptosis
18) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.34 Pain Relevance 0.21
High levels of Bcl2 protein expression have been found in many different types of cancer, suggesting a possible role for Bcl2 deregulation of apoptosis and malignant tissue transformation.
Regulation (deregulation) of Bcl2 associated with malignant neoplastic disease, cancer and apoptosis
19) Confidence 0.23 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.33 Pain Relevance 0
Moreover, there was no change in Bcl-2 protein content between CR and AL mice.
Neg (no) Regulation (change) of Bcl-2
20) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.11 Pain Relevance 0.09

General Comments

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