INT64248

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.97
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 4
brain 2
striatum 2
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 574 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
gABA 26 97.92 Very High Very High Very High
Ventral tegmentum 16 97.00 Very High Very High Very High
cocaine 3 90.52 High High
Morphine 2 90.04 High High
Opioid 1 88.44 High High
adenocard 2 81.52 Quite High
antagonist 41 79.76 Quite High
Neurotransmitter 18 79.64 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 21 99.86 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 329 99.48 Very High Very High Very High
Targeted Disruption 18 97.56 Very High Very High Very High
Muscle Rigidity 1 93.48 High High
Disease 27 86.16 High High
Ocular Toxicity (including Many Sub-types) 22 85.76 High High
Stress 11 84.72 Quite High
Congenital Anomalies 7 61.44 Quite High
Apoptosis 10 54.12 Quite High
Cognitive Disorder 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies in rodent brain slice preparations have suggested that the reduction of dopaminergic transmission in the parkinsonian state results in a lack of activation of D2LRs and D1-receptors which, in turn, contributes to the development of irregular discharges in the STN (see section on STN above).
Positive_regulation (results) of Positive_regulation (activation) of D1-receptor in brain associated with parkinson's disease
1) Confidence 0.45 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.54 Pain Relevance 0.25
As previous studies have shown enhancement of DA neurotransmission often results in elevated dynorphin and DRD1 mRNA levels in direct striatal projecting neurons, the unbalance between the direct and indirect striatal projection pathways observed in Pten KO animals could be explained by subtle but long-term changes in DA dynamics.
Positive_regulation (results) of Positive_regulation (elevated) of DRD1 mRNA in neurons associated with dopamine and dynorphin
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.11 Pain Relevance 0.55
The increase in DRD1 density observed in SHR striatum is reversed by methylphenidate treatment suggesting that psychostimulants reduce ADHD-like behaviour of SHR by increasing dopamine activation of DRD1 [51,81,82] thereby enabling dopamine-mediated LTP and reinforcement mechanisms to take place.
Positive_regulation (increasing) of Positive_regulation (activation) of DRD1 in striatum associated with dopamine and attention deficit hyperactivity disorder
3) Confidence 0.24 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.50 Pain Relevance 0.44
Hyperactivity in the DAT1 knock-out mouse might be the result of increased dopamine tone or decreased phasic dopamine release with consequently impaired activation of postsynaptic DRD1 required for LTP (and LTD) to produce changes in synaptic strength necessary for associative learning and reinforcement of appropriate behaviour.
Positive_regulation (required) of Positive_regulation (activation) of DRD1 associated with targeted disruption, dopamine and attention deficit hyperactivity disorder
4) Confidence 0.24 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.67 Pain Relevance 0.51
Normally, D1 receptor activation augmented the amplitude of a gamma-aminobutyric acid type B (GABA(B)) inhibitory postsynaptic potential (IPSP), but in drug-experienced animals, D1 receptor activation caused an inhibition of the GABA(B) IPSP.
Positive_regulation (augmented) of Positive_regulation (activation) of D1 receptor associated with gaba
5) Confidence 0.22 Published 1996 Journal Neuron Section Abstract Doc Link 8785060 Disease Relevance 0 Pain Relevance 0.72
Our work indicates that MDMA induces DA-dependent ERK activation in D1 receptor-expressing neurons that likely triggers the same signaling cascade as other drugs of abuse.
Positive_regulation (induces) of Positive_regulation (activation) of D1 receptor-expressing in neurons associated with dopamine
6) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.15 Pain Relevance 0.15

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