INT64261

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 16.28
Pain Relevance 19.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
sciatic nerve 4
paw 4
tube 2
liver 2
neurons 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 441 100.00 Very High Very High Very High
Hyperalgesia 41 100.00 Very High Very High Very High
cytokine 15 100.00 Very High Very High Very High
Inflammation 81 99.90 Very High Very High Very High
dexamethasone 3 99.76 Very High Very High Very High
antagonist 15 99.70 Very High Very High Very High
substance P 33 99.38 Very High Very High Very High
Pain 12 99.36 Very High Very High Very High
guanethidine 2 98.76 Very High Very High Very High
agonist 12 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 59 100.00 Very High Very High Very High
INFLAMMATION 75 99.90 Very High Very High Very High
Pain 10 99.36 Very High Very High Very High
Nervous System Injury 37 99.12 Very High Very High Very High
Pressure And Volume Under Development 17 99.08 Very High Very High Very High
Hypersensitivity 4 99.08 Very High Very High Very High
Urological Neuroanatomy 5 98.88 Very High Very High Very High
Injury 91 98.00 Very High Very High Very High
Ganglion Cysts 83 96.76 Very High Very High Very High
Necrosis 1 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, at these doses, neither anti-inflammatory agent reduced the elevated levels of NGF.
Negative_regulation (reduced) of Positive_regulation (elevated) of NGF associated with nerve growth factor and inflammation
1) Confidence 0.59 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10653021 Disease Relevance 1.04 Pain Relevance 0.96
Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw.
Negative_regulation (prevent) of Positive_regulation (increase) of nerve growth factor in paw associated with pressure and volume under development, inflammation and nerve growth factor
2) Confidence 0.59 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10653021 Disease Relevance 0.77 Pain Relevance 0.81
Terbutaline also inhibited the increase in NGF caused by intraplantar injection of the NK1 receptor agonist substance P (SP), but did not significantly affect that caused by carrageenan.
Negative_regulation (inhibited) of Positive_regulation (increase) of NGF associated with nerve growth factor, agonist and substance p
3) Confidence 0.59 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0.19 Pain Relevance 1.27
HOE 140 inhibited the upregulation of NGF.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of NGF associated with nerve growth factor
4) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20220009 Disease Relevance 1.07 Pain Relevance 1.47
In the PNS, the increase in NGF-IR was inhibited at 1, 2, and 4 weeks after surgery in the tube group, suggesting that this could be one of the pain-like behavior inhibitory effects.
Negative_regulation (inhibited) of Positive_regulation (increase) of NGF-IR in tube associated with pain and nerve growth factor
5) Confidence 0.56 Published 2006 Journal J. Orthop. Res. Section Abstract Doc Link 16732614 Disease Relevance 0.43 Pain Relevance 0.48
Treatment with any one of the three sympatholytics abolished the upregulation of NGF and IL-6, while phentolamine and guanethedine also reversed the upregulation of TNF-alpha.
Negative_regulation (abolished) of Positive_regulation (upregulation) of NGF associated with nerve growth factor
6) Confidence 0.56 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015213 Disease Relevance 0.95 Pain Relevance 0.98
In contrast, a supramaximal dose of indomethacin (6 mg/kg) partially inhibited, and dexamethasone completely prevented the carrageenan-induced increase in NGF.
Negative_regulation (prevented) of Positive_regulation (increase) of NGF associated with nerve growth factor and dexamethasone
7) Confidence 0.51 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10653021 Disease Relevance 1.02 Pain Relevance 0.96
In contrast, mast cell degranulation produced by several days of treatment with the cationic secretagogue compound 48/80, while also increasing basal NGF levels, prevented a further increase in NGF levels and attenuated hypersensitivity during inflammation.
Negative_regulation (prevented) of Positive_regulation (increase) of NGF in mast cell associated with inflammation, nerve growth factor and hypersensitivity
8) Confidence 0.43 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8786447 Disease Relevance 1.15 Pain Relevance 1.08
Colchicine (0.3 and 1 mg/kg) attenuated the NGF (0.8 and 4 microg)-induced increase in tissue myeloperoxidase (MPO) as determined 6 h after NGF application.
Negative_regulation (attenuated) of Positive_regulation (increase) of NGF associated with nerve growth factor and urological neuroanatomy
9) Confidence 0.43 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750013 Disease Relevance 0.88 Pain Relevance 0.95
The SP, H2 antagonists and ketotifen prevented the upregulation of all cytokines and nerve growth factor (NGF) levels, while the CGRP and H1 antagonists showed only attenuation of the NGF level.
Negative_regulation (prevented) of Positive_regulation (upregulation) of NGF in nerve associated with nerve growth factor, antagonist, cytokine and substance p
10) Confidence 0.43 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15265675 Disease Relevance 0.25 Pain Relevance 1.23
Zinc treatment (20 nmole) significantly reduced sensitivity in the early phase of the inflammation and diminished the increase in the levels of IL-1 beta and NGF without affecting paw swelling.
Negative_regulation (diminished) of Positive_regulation (increase) of NGF in paw associated with pressure and volume under development, nerve growth factor and inflammation
11) Confidence 0.43 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887968 Disease Relevance 0.78 Pain Relevance 0.84
Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat.
Negative_regulation (reduces) of Positive_regulation (upregulation) of NGF associated with hyperalgesia and inflammation
12) Confidence 0.43 Published 1996 Journal Neuropharmacology Section Title Doc Link 8887968 Disease Relevance 0.76 Pain Relevance 0.79
The NGF increase was suppressed by treatment of rats with the selective tachykinin NK1 receptor antagonist SR140333 (0.1 mg/kg), and by the beta adrenergic agonist terbutaline (0.3 mg/kg).
Negative_regulation (suppressed) of Positive_regulation (increase) of NGF associated with nerve growth factor, antagonist and agonist
13) Confidence 0.43 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0.23 Pain Relevance 1.20
Repeated treatments with the antihyperalgesic and neuroregenerative compound acetyl-l-carnitine (ALCAR; 100 mgkg(-1) i.p. twice daily for 15 days) was able to prevent the increase of NGF levels.
Negative_regulation (prevent) of Positive_regulation (increase) of NGF associated with antihyperalgesic and nerve growth factor
14) Confidence 0.43 Published 2010 Journal Neuroscience Section Abstract Doc Link 20302919 Disease Relevance 1.12 Pain Relevance 1.00
At week 8, DCMAP in group of LBD-NGF was significantly restored compared with groups of NAT-NGF and the control (n?
Negative_regulation (restored) of Positive_regulation (group) of LBD-NGF associated with nerve growth factor
15) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.67 Pain Relevance 0.79
It also abolished the thymulin-induced increase in the level of cytokines and NGF in the liver.
Negative_regulation (abolished) of Positive_regulation (increase) of NGF in liver associated with cytokine
16) Confidence 0.42 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10854910 Disease Relevance 0.51 Pain Relevance 0.72
NGF, in the setting of inflammation, is known to increase TRPV1 protein, but not mRNA, through activation of the p38/MAP kinase pathway [25,26], and NGF-mediated upregulation of TRPV1 is blocked by over-expression of dominant-negative ras [26].
Negative_regulation (blocked) of Positive_regulation (upregulation) of NGF-mediated associated with inflammation and nerve growth factor
17) Confidence 0.41 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.52 Pain Relevance 0.84
Sympathectomy, produced by neonatal guanethidine treatment, elevated basal NGF levels in the skin but did not attenuate a further increase in NGF during inflammation.
Neg (not) Negative_regulation (attenuate) of Positive_regulation (increase) of NGF in skin associated with inflammation, nerve growth factor and guanethidine
18) Confidence 0.38 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8786447 Disease Relevance 1.08 Pain Relevance 1.00
On the other hand, the nerve growth factor (NGF)-induced increase in BDNF expression in small-to-medium-diameter neurons was reversed by SB203580, whereas the anti-NGF-induced increase in NPY in medium-sized and large-sized neurons was partially blocked by U0126.
Negative_regulation (blocked) of Positive_regulation (increase) of anti-NGF-induced in neurons associated with nerve growth factor
19) Confidence 0.35 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.44 Pain Relevance 1.20
Complete sciatic nerve injury reduces substance P (SP) expression in primary sensory neurons of the L4 and L5 dorsal root ganglia (DRG), due to loss of target-derived nerve growth factor (NGF).
Negative_regulation (loss) of Positive_regulation (target-derived) of NGF in sciatic nerve associated with nervous system injury, nerve growth factor, sciatic nerve and substance p
20) Confidence 0.20 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9749767 Disease Relevance 0.74 Pain Relevance 0.62

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