INT64270

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.72
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM2) intracellular (GRM2) signal transducer activity (GRM2)
Anatomy Link Frequency
oocytes 3
spinal 1
medial forebrain bundle 1
amygdala 1
synapses 1
GRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 24 99.96 Very High Very High Very High
withdrawal 23 99.76 Very High Very High Very High
allodynia 8 99.62 Very High Very High Very High
cocaine 4 99.54 Very High Very High Very High
opiate 11 99.44 Very High Very High Very High
Hyperalgesia 10 99.12 Very High Very High Very High
halothane 15 99.02 Very High Very High Very High
Inflammation 32 98.86 Very High Very High Very High
agonist 11 98.06 Very High Very High Very High
isoflurane 10 98.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 99.62 Very High Very High Very High
Hyperalgesia 11 99.12 Very High Very High Very High
INFLAMMATION 40 98.86 Very High Very High Very High
Recurrence 2 98.72 Very High Very High Very High
Death 4 97.44 Very High Very High Very High
Pain 119 97.14 Very High Very High Very High
Injury 10 94.90 High High
Apoptosis 2 59.04 Quite High
Nociception 9 58.60 Quite High
Neurodegenerative Disease 4 57.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the clinical anesthetics enflurane, isoflurane and halothane, we tested novel halogenated compounds, which are anesthetic or nonanesthetic in vivo, on glutamate receptor (GluR) subunits. these volatile compounds as well as pentobarbital and phenobarbital were tested on kainate-induced currents in Xenopus oocytes expressing GluR1, GluR3, GluR2+3 or GluR6 subunits.
Gene_expression (expressing) of GluR2 in oocytes associated with glutamate receptor, halothane and isoflurane
1) Confidence 0.75 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786535 Disease Relevance 0 Pain Relevance 0.31
There was a reduction in glutamate receptor (GluR2) expression, a persistent increase in intracellular calcium concentration, activation of calpain, and an increase in spectrin breakdown products.
Gene_expression (expression) of GluR2 associated with glutamate receptor
2) Confidence 0.75 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19508430 Disease Relevance 0.30 Pain Relevance 0.43
Cocaine withdrawal alters the expression of GluR1 and GluR2/3 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in nucleus accumbens or amygdala, but the influence of drug withdrawal on hippocampus is little known.
Gene_expression (expression) of GluR2 in amygdala associated with nucleus accumbens, hippocampus, amygdala, withdrawal and cocaine
3) Confidence 0.75 Published 2006 Journal Life Sci. Section Abstract Doc Link 16616767 Disease Relevance 0.10 Pain Relevance 0.63
These findings indicate that opiate withdrawal induces dynamic expression of GluR1 and GluR2/3 subunits of AMPA receptors in hippocampal synapses, possibly revealing an adaptive process of the hippocampal functions following opiate withdrawal.
Gene_expression (expression) of GluR2 in synapses associated with opiate and withdrawal
4) Confidence 0.75 Published 2006 Journal Life Sci. Section Abstract Doc Link 16616767 Disease Relevance 0 Pain Relevance 1.24
We report that repeated exposure to rewarding stimulation of the medial forebrain bundle (MFB) selectively decreases expression of GluR1 (an AMPA receptor subunit) in the VTA, without effect on expression of several other proteins (GluR2, NMDAR1, tyrosine hydroxylase).
Gene_expression (expression) of GluR2 in medial forebrain bundle
5) Confidence 0.75 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11425507 Disease Relevance 0 Pain Relevance 0.29
The anesthetic 1-chloro-1,2,2-triflurocyclobutane (F3) weakly inhibited kainate responses in oocytes expressing GluR3 receptors but not oocytes expressing GluR1 or GluR2+3 receptors.
Neg (not) Gene_expression (expressing) of GluR2 in oocytes
6) Confidence 0.75 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786535 Disease Relevance 0 Pain Relevance 0.37
Isoflurane weakly inhibited although enflurane and halothane modestly inhibited kainate responses in oocytes expressing GluR1, GluR3 or GluR2+3 receptors.
Gene_expression (expressing) of GluR2 in oocytes associated with halothane and isoflurane
7) Confidence 0.75 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8786535 Disease Relevance 0 Pain Relevance 0.50
A fragment of GluR2 cDNA was generated from a human cDNA library, and in situ hybridization revealed an expression pattern similar to that of GluR2 proteins.
Gene_expression (expression) of GluR2
8) Confidence 0.65 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507323 Disease Relevance 0 Pain Relevance 0.20
It is possible that the interaction of Tmub1 with GluR2-GRIP is indirect and requires another mediator.
Gene_expression (with) of GluR2
9) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.06 Pain Relevance 0.10
Metabotropic group II receptors (mGluR2 and mGluR3) also modulate pain transmission. mGluR2 is located in sensory neurones and presynaptic nerve terminals whereas mGluR3 is found all over the brain. mGluR3 can be selectively increased in the spinal dorsal horn neurones after peripheral UV injury [94]. mGluR2/3 receptor activation appears necessary to reduce nerve terminal excitability and to modulate pain transmission since treatment with the agonist L-acetyl carnitine reduced inflammatory hyperalgesia and mechanical allodynia and increased the expression of mGluR2/3.
Gene_expression (expression) of mGluR2 in spinal associated with pain, hyperalgesia, allodynia, inflammation, spinal dorsal horn, injury and agonist
10) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.26 Pain Relevance 1.35

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