INT64279

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2007
Negated 0
Speculated 3
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.54
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
stomach 1
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 9 99.48 Very High Very High Very High
Pain 16 96.96 Very High Very High Very High
Inflammation 37 96.56 Very High Very High Very High
allodynia 6 95.68 Very High Very High Very High
IPN 8 95.16 Very High Very High Very High
intrathecal 2 92.28 High High
bradykinin 6 89.76 High High
Thermal hyperalgesia 30 88.24 High High
Inflammatory response 2 85.64 High High
anesthesia 1 80.80 Quite High
Disease Link Frequency Relevance Heat
Neurological Disease 2 97.56 Very High Very High Very High
Pain 17 96.96 Very High Very High Very High
INFLAMMATION 48 96.56 Very High Very High Very High
Neuropathic Pain 6 95.68 Very High Very High Very High
Inflammatory Pain 8 95.16 Very High Very High Very High
Hyperalgesia 36 88.24 High High
Nociception 22 75.12 Quite High
Sprains And Strains 6 69.76 Quite High
Ganglion Cysts 54 15.32 Low Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the roles of cyclooxygenase (COX) isozymes and prostaglandin E (PGE) receptor EP1 and EP3 subtypes or prostacyclin IP receptors in the decrease in acid secretion in the damaged mouse stomach.
Spec (investigated) Regulation (roles) of EP1 in stomach
1) Confidence 0.41 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17928639 Disease Relevance 0 Pain Relevance 0.08
In the present study, we examined the effect of the PGE receptor EP1 subtype antagonist ONO-NT-012, the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, and the NO synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) on the allodynia.
Spec (examined) Regulation (effect) of PGE receptor associated with allodynia and antagonist
2) Confidence 0.35 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8786849 Disease Relevance 0.52 Pain Relevance 0.81
Given the fact that one of the final targets of both PGE2 and PGI2 is TRPV1 as shown in our study, compounds acting on EP1, IP or TRPV1, or interfering with their interaction could prove useful in the treatment of pain and inflammation.


Regulation (acting) of EP1 associated with pain and inflammation
3) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.83 Pain Relevance 0.56
Therefore, we examined whether a similar signal transduction pathway is involved in the regulation of TRPV1 responses through EP1.
Spec (whether) Regulation (regulation) of EP1
4) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.11
The neuromodulatory effects of PGE(2) are mediated through regulation of four G-protein-coupled receptors known as EP1, EP2, EP3, and EP4.
Regulation (regulation) of EP1
5) Confidence 0.18 Published 2006 Journal J. Neurotrauma Section Abstract Doc Link 17184197 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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